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Identification
HMDB Protein ID HMDBP08077
Secondary Accession Numbers
  • 13788
Name Short transient receptor potential channel 5
Synonyms
  1. TRP-5
  2. Transient receptor protein 5
  3. TrpC5
  4. hTRP-5
  5. hTRP5
Gene Name TRPC5
Protein Type Unknown
Biological Properties
General Function Involved in ion channel activity
Specific Function Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
cation channel activity
calcium channel activity
Process
di-, tri-valent inorganic cation transport
divalent metal ion transport
calcium ion transport
establishment of localization
transport
transmembrane transport
ion transport
cation transport
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein (Probable)
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs TRPC5
Gene Sequence
>2922 bp
ATGGCCCAACTGTACTACAAAAAGGTCAACTACTCACCGTACAGAGACCGCATCCCCCTG
CAAATTGTGAGGGCTGAGACAGAGCTCTCTGCAGAGGAGAAGGCCTTCCTCAATGCTGTG
GAGAAGGGGGACTATGCCACTGTGAAGCAGGCCCTTCAGGAGGCTGAGATCTACTATAAT
GTTAACATCAACTGCATGGACCCCTTGGGCCGGAGTGCCCTGCTCATTGCCATTGAGAAC
GAGAACCTGGAGATCATGGAGCTACTGCTGAACCACAGCGTGTATGTGGGTGATGCATTG
CTCTATGCCATACGCAAGGAAGTGGTGGGCGCTGTGGAGCTTCTGCTCAGCTACAGGCGG
CCCAGCGGAGAGAAGCAGGTCCCCACTCTGATGATGGACACGCAGTTCTCTGAATTCACA
CCGGACATCACTCCCATCATGCTGGCTGCCCACACCAACAACTACGAAATCATCAAATTG
CTTGTCCAAAAACGGGTCACTATCCCACGGCCCCACCAGATCCGCTGCAACTGTGTGGAG
TGTGTGTCTAGTTCAGAGGTAGACAGCCTGCGCCACTCTCGCTCCCGACTGAACATCTAT
AAGGCTCTGGCAAGCCCCTCACTCATTGCCTTATCAAGTGAGGACCCCATCCTAACTGCC
TTCCGTCTGGGCTGGGAGCTCAAGGAGCTCAGCAAGGTGGAGAATGAGTTCAAGGCCGAG
TATGAGGAGCTCTCTCAGCAGTGCAAGCTCTTTGCCAAAGACCTGCTGGACCAAGCTCGG
AGCTCCAGGGAACTGGAGATCATCCTCAACCATCGAGATGACCACAGTGAAGAGCTTGAC
CCTCAGAAGTACCATGACCTGGCCAAGTTGAAGGTGGCAATCAAATACCACCAGAAAGAG
TTTGTTGCTCAGCCCAACTGCCAACAGTTGCTTGCCACCCTGTGGTATGATGGCTTCCCT
GGATGGCGGCGGAAACACTGGGTAGTCAAGCTTCTAACCTGCATGACCATTGGGTTCCTG
TTTCCCATGCTGTCTATAGCCTACCTGATCTCACCCAGGAGCAACCTTGGGCTGTTCATC
AAGAAACCCTTTATCAAGTTTATCTGCCACACAGCATCCTATTTGACCTTCCTCTTTATG
CTTCTCCTGGCTTCTCAGCACATTGTCAGGACAGACCTTCATGTACAGGGGCCTCCCCCA
ACTGTCGTGGAATGGATGATATTGCCTTGGGTTCTAGGTTTCATTTGGGGTGAGATTAAG
GAAATGTGGGATGGTGGATTTACTGAATACATCCATGACTGGTGGAACCTGATGGATTTT
GCAATGAACTCCCTCTACCTGGCAACTATTTCCCTGAAGATTGTGGCCTATGTCAAGTAT
AATGGTTCTCGTCCAAGGGAGGAATGGGAAATGTGGCACCCGACTCTGATTGCGGAAGCA
CTCTTCGCAATATCCAACATTTTAAGTTCGTTGCGTCTCATATCCCTGTTCACAGCCAAC
TCCCACTTAGGACCTCTGCAGATCTCTTTGGGACGCATGCTGCTTGATATCCTCAAATTC
CTCTTTATCTACTGCCTGGTACTACTAGCTTTTGCCAATGGACTGAACCAGCTTTACTTC
TATTATGAAACCAGAGCTATCGATGAGCCTAACAACTGCAAGGGGATCCGATGTGAGAAA
CAGAACAATGCCTTCTCCACGCTCTTTGAGACTCTTCAGTCACTCTTCTGGTCTGTATTT
GGCCTTTTAAATCTATATGTCACCAATGTGAAAGCCAGACACGAATTCACCGAGTTTGTA
GGAGCTACCATGTTTGGAACATACAATGTCATCTCCCTGGTAGTGCTGCTGAACATGCTG
ATTGCTATGATGAACAACTCCTATCAGCTTATTGCCGATCATGCTGATATCGAGTGGAAG
TTTGCAAGGACGAAGCTCTGGATGAGTTACTTTGATGAAGGTGGCACCTTGCCACCTCCT
TTCAACATCATCCCCAGCCCCAAGTCATTTCTATACCTTGGTAACTGGTTCAACAACACC
TTCTGCCCCAAAAGAGACCCTGACGGTAGACGGAGAAGGCGCAACTTGAGAAGTTTCACA
GAACGCAATGCTGACAGCCTGATACAAAATCAACATTATCAGGAAGTTATCAGGAATTTA
GTCAAAAGATATGTGGCTGCTATGATAAGAAATTCCAAAACACATGAGGGACTTACAGAA
GAAAATTTTAAGGAATTAAAGCAAGACATCTCCAGCTTTCGGTATGAAGTGCTTGACCTC
TTGGGAAATAGAAAACATCCAAGGAGCTTTTCCACTAGCAGCACTGAACTGTCTCAGAGA
GACGATAATAATGATGGCAGTGGTGGGGCTCGGGCCAAATCCAAGAGTGTCTCTTTTAAT
TTAGGCTGCAAGAAAAAGACTTGCCATGGGCCACCTCTCATCAGAACCATGCCAAGGTCC
AGTGGTGCCCAAGGAAAGTCAAAAGCTGAGTCATCAAGCAAACGCTCCTTCATGGGTCCT
TCTCTCAAGAAACTGGGTCTCCTATTCTCCAAATTTAATGGTCATATGTCTGAACCCAGT
TCAGAGCCAATGTACACAATTTCTGATGGAATTGTTCAGCAGCACTGTATGTGGCAGGAC
ATCAGATATTCTCAGATGGAGAAAGGGAAAGCAGAGGCCTGTTCTCAAAGTGAAATTAAC
CTCAGTGAGGTAGAATTAGGTGAAGTCCAGGGCGCTGCTCAGAGCAGTGAATGCCCTCTA
GCCTGTTCCAGCTCTCTTCACTGTGCATCCAGCATCTGCTCCTCAAATTCTAAACTTTTA
GACTCCTCAGAGGATGTATTTGAAACTTGGGGAGAGGCTTGTGACTTGCTCATGCACAAA
TGGGGTGATGGACAGGAAGAACAAGTTACAACTCGCCTCTAA
Protein Properties
Number of Residues 973
Molecular Weight 111411.0
Theoretical pI 7.31
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 331-351
  • 399-419
  • 438-458
  • 471-491
  • 513-533
  • 604-624
Protein Sequence
>Short transient receptor potential channel 5
MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYN
VNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRR
PSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVE
CVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAE
YEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKE
FVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFI
KKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIK
EMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEA
LFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF
YYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFV
GATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPP
FNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNL
VKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRSFSTSSTELSQR
DDNNDGSGGARAKSKSVSFNLGCKKKTCHGPPLIRTMPRSSGAQGKSKAESSSKRSFMGP
SLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQQHCMWQDIRYSQMEKGKAEACSQSEIN
LSEVELGEVQGAAQSSECPLACSSSLHCASSICSSNSKLLDSSEDVFETWGEACDLLMHK
WGDGQEEQVTTRL
GenBank ID Protein 6002474
UniProtKB/Swiss-Prot ID Q9UL62
UniProtKB/Swiss-Prot Entry Name TRPC5_HUMAN
PDB IDs Not Available
GenBank Gene ID AF054568
GeneCard ID TRPC5
GenAtlas ID TRPC5
HGNC ID HGNC:12337
References
General References
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  3. Miehe S, Bieberstein A, Arnould I, Ihdene O, Rutten H, Strubing C: The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5. J Biol Chem. 2010 Apr 16;285(16):12426-34. doi: 10.1074/jbc.M109.068304. Epub 2010 Feb 17. [PubMed:20164195 ]
  4. Lussier MP, Cayouette S, Lepage PK, Bernier CL, Francoeur N, St-Hilaire M, Pinard M, Boulay G: MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC. J Biol Chem. 2005 May 13;280(19):19393-400. Epub 2005 Mar 9. [PubMed:15757897 ]
  5. Lussier MP, Lepage PK, Bousquet SM, Boulay G: RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC. Cell Calcium. 2008 May;43(5):432-43. Epub 2007 Sep 11. [PubMed:17850865 ]
  6. Hofmann T, Schaefer M, Schultz G, Gudermann T: Subunit composition of mammalian transient receptor potential channels in living cells. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7461-6. [PubMed:12032305 ]
  7. Sossey-Alaoui K, Lyon JA, Jones L, Abidi FE, Hartung AJ, Hane B, Schwartz CE, Stevenson RE, Srivastava AK: Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca2+ entry channel. Genomics. 1999 Sep 15;60(3):330-40. [PubMed:10493832 ]
  8. Philipp S, Hambrecht J, Braslavski L, Schroth G, Freichel M, Murakami M, Cavalie A, Flockerzi V: A novel capacitative calcium entry channel expressed in excitable cells. EMBO J. 1998 Aug 3;17(15):4274-82. [PubMed:9687496 ]
  9. Kinoshita-Kawada M, Tang J, Xiao R, Kaneko S, Foskett JK, Zhu MX: Inhibition of TRPC5 channels by Ca2+-binding protein 1 in Xenopus oocytes. Pflugers Arch. 2005 Aug;450(5):345-54. Epub 2005 May 14. [PubMed:15895247 ]