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Identification |
HMDB Protein ID
| HMDBP08105 |
Secondary Accession Numbers
| |
Name
| ADM2 |
Synonyms
|
- AM2
- Adrenomedullin-2
- IMDL
- IMDS
- Intermedin
- Intermedin-long
- Intermedin-short
|
Gene Name
| ADM2 |
Protein Type
| Unknown |
Biological Properties |
General Function
| Involved in hormone activity |
Specific Function
| IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway |
Pathways
|
Not Available
|
Reactions
| Not Available |
GO Classification
|
Component |
extracellular region |
Function |
hormone activity |
binding |
protein binding |
receptor binding |
|
Cellular Location
|
- Secreted
|
Gene Properties |
Chromosome Location
| Chromosome:2 |
Locus
| 22q13.33 |
SNPs
| ADM2 |
Gene Sequence
|
>447 bp
ATGGCCCGGATCCCGACGGCCGCCCTGGGTTGCATCAGCCTCCTCTGCCTGCAGCTCCCT
GGCTCGCTGTCCCGCAGCCTGGGCGGGGACCCGCGACCCGTCAAACCCAGGGAGCCCCCA
GCCCGGAGCCCTTCCAGCAGCCTGCAGCCCAGGCACCCCGCACCCCGACCTGTGGTCTGG
AAGCTTCACCGGGCCCTCCAGGCACAGAGGGGTGCCGGCCTGGCCCCTGTTATGGGTCAG
CCTCTCCGGGATGGTGGCCGCCAACACTCGGGCCCCCGAAGACACTCGGGCCCCCGCAGG
ACCCAAGCCCAGCTCCTGCGAGTGGGCTGTGTGCTGGGCACCTGCCAGGTGCAGAATCTC
AGCCACCGCCTGTGGCAACTCATGGGACCGGCCGGCCGGCAGGACTCAGCTCCTGTGGAC
CCCAGCAGCCCCCACAGCTATGGCTGA
|
Protein Properties |
Number of Residues
| 148 |
Molecular Weight
| 15865.2 |
Theoretical pI
| 12.31 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>ADM2
MARIPTAALGCISLLCLQLPGSLSRSLGGDPRPVKPREPPARSPSSSLQPRHPAPRPVVW
KLHRALQAQRGAGLAPVMGQPLRDGGRQHSGPRRHSGPRRTQAQLLRVGCVLGTCQVQNL
SHRLWQLMGPAGRQDSAPVDPSSPHSYG
|
External Links |
GenBank ID Protein
| 41016726 |
UniProtKB/Swiss-Prot ID
| Q7Z4H4 |
UniProtKB/Swiss-Prot Entry Name
| ADM2_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AB121034 |
GeneCard ID
| ADM2 |
GenAtlas ID
| ADM2 |
HGNC ID
| HGNC:28898 |
References |
General References
| - Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al.: The DNA sequence of human chromosome 22. Nature. 1999 Dec 2;402(6761):489-95. [PubMed:10591208 ]
- Roh J, Chang CL, Bhalla A, Klein C, Hsu SY: Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes. J Biol Chem. 2004 Feb 20;279(8):7264-74. Epub 2003 Nov 13. [PubMed:14615490 ]
- Takei Y, Inoue K, Ogoshi M, Kawahara T, Bannai H, Miyano S: Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator. FEBS Lett. 2004 Jan 2;556(1-3):53-8. [PubMed:14706825 ]
- Takahashi K, Kikuchi K, Maruyama Y, Urabe T, Nakajima K, Sasano H, Imai Y, Murakami O, Totsune K: Immunocytochemical localization of adrenomedullin 2/intermedin-like immunoreactivity in human hypothalamus, heart and kidney. Peptides. 2006 Jun;27(6):1383-9. Epub 2005 Dec 15. [PubMed:16359754 ]
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