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Survey
Identification
HMDB Protein ID HMDBP08123
Secondary Accession Numbers
  • 13834
Name Luc7-like protein 3
Synonyms
  1. CRE-associated protein 1
  2. CREAP-1
  3. Cisplatin resistance-associated-overexpressed protein
  4. Luc7A
  5. Okadaic acid-inducible phosphoprotein OA48-18
  6. cAMP regulatory element-associated protein 1
Gene Name LUC7L3
Protein Type Unknown
Biological Properties
General Function Involved in DNA binding
Specific Function Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Nucleus speckle
Gene Properties
Chromosome Location Chromosome:1
Locus 17q21.33
SNPs LUC7L3
Gene Sequence
>1299 bp
ATGATTTCGGCCGCGCAGTTGTTGGATGAGTTAATGGGCCGGGACCGAAACCTAGCCCCG
GACGAGAAGCGCAGCAACGTGCGGTGGGACCACGAGAGCGTTTGTAAATATTATCTCTGT
GGTTTTTGTCCTGCGGAATTGTTCACAAATACACGTTCTGATCTTGGTCCGTGTGAAAAA
ATTCATGATGAAAATCTACGAAAACAGTATGAGAAGAGCTCTCGTTTCATGAAAGTTGGC
TATGAAAGAGATTTTTTGCGATACTTACAGAGCTTACTTGCAGAAGTAGAACGTAGGATC
AGACGAGGCCATGCTCGTTTGGCATTATCTCAAAACCAGCAGTCTTCTGGGGCCGCTGGC
CCAACAGGCAAAAATGAAGAAAAAATTCAGGTTCTAACAGACAAAATTGATGTACTTCTG
CAACAGATTGAAGAATTAGGGTCTGAAGGAAAAGTAGAAGAAGCCCAGGGGATGATGAAA
TTAGTTGAGCAATTAAAAGAAGAGAGAGAACTGCTAAGGTCCACAACGTCGACAATTGAA
AGCTTTGCTGCACAAGAAAAACAAATGGAAGTTTGTGAAGTATGTGGAGCCTTTTTAATA
GTAGGAGATGCCCAGTCCCGGGTAGATGACCATTTGATGGGAAAACAACACATGGGCTAT
GCCAAAATTAAAGCTACTGTAGAAGAATTAAAAGAAAAGTTAAGGAAAAGAACCGAAGAA
CCTGATCGTGATGAGCGTCTAAAAAAGGAGAAGCAAGAAAGAGAAGAAAGAGAAAAAGAA
CGGGAGAGAGAAAGGGAAGAAAGAGAAAGGAAAAGACGAAGGGAAGAGGAAGAAAGAGAA
AAAGAAAGGGCTCGTGACAGAGAAAGAAGAAAGAGAAGTCGTTCACGAAGTAGACACTCA
AGCCGAACATCAGACAGAAGATGCAGCAGGTCTCGGGACCACAAAAGGTCACGAAGTAGA
GAAAGAAGGCGGAGCAGAAGTAGAGATCGACGAAGAAGCAGAAGCCATGATCGATCAGAA
AGAAAACACAGATCTCGAAGTCGGGATCGAAGAAGATCAAAAAGCCGGGATCGAAAGTCA
TATAAGCACAGGAGCAAAAGTCGGGACAGAGAACAAGATAGAAAATCCAAGGAGAAAGAA
AAGAGGGGATCTGATGATAAAAAAAGTAGTGTGAAGTCCGGTAGTCGAGAAAAGCAGAGT
GAAGACACAAACACTGAATCGAAGGAAAGTGATACTAAGAATGAGGTCAATGGGACCAGT
GAAGACATTAAATCTGAAGGTGACACTCAGTCCAATTAA
Protein Properties
Number of Residues 432
Molecular Weight 51465.7
Theoretical pI 10.46
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Luc7-like protein 3
MISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEK
IHDENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAG
PTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIE
SFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEE
PDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHS
SRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKS
YKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTS
EDIKSEGDTQSN
GenBank ID Protein 6899846
UniProtKB/Swiss-Prot ID O95232
UniProtKB/Swiss-Prot Entry Name LC7L3_HUMAN
PDB IDs Not Available
GenBank Gene ID AB034205
GeneCard ID LUC7L3
GenAtlas ID LUC7L3
HGNC ID HGNC:24309
References
General References
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  3. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [PubMed:19608861 ]
  4. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  5. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
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  7. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
  8. Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007 May 25;316(5828):1160-6. [PubMed:17525332 ]
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  10. Nishii Y, Morishima M, Kakehi Y, Umehara K, Kioka N, Terano Y, Amachi T, Ueda K: CROP/Luc7A, a novel serine/arginine-rich nuclear protein, isolated from cisplatin-resistant cell line. FEBS Lett. 2000 Jan 14;465(2-3):153-6. [PubMed:10631324 ]
  11. Shipman KL, Robinson PJ, King BR, Smith R, Nicholson RC: Identification of a family of DNA-binding proteins with homology to RNA splicing factors. Biochem Cell Biol. 2006 Feb;84(1):9-19. [PubMed:16462885 ]
  12. Chin LS, Singh SK, Wang Q, Murray SF: Identification of okadaic-acid-induced genes by mRNA differential display in glioma cells. J Biomed Sci. 2000 Mar-Apr;7(2):152-9. [PubMed:10754390 ]
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  14. Zhou A, Ou AC, Cho A, Benz EJ Jr, Huang SC: Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection. Mol Cell Biol. 2008 Oct;28(19):5924-36. doi: 10.1128/MCB.00560-08. Epub 2008 Jul 28. [PubMed:18663000 ]