Hmdb loader
Identification
HMDB Protein ID HMDBP08147
Secondary Accession Numbers
  • 13858
Name Potassium voltage-gated channel subfamily H member 8
Synonyms
  1. ELK channel 3
  2. ELK1
  3. ELK3
  4. Ether-a-go-go-like potassium channel 3
  5. Voltage-gated potassium channel subunit Kv12.1
  6. hElk1
Gene Name KCNH8
Protein Type Unknown
Biological Properties
General Function Involved in ion channel activity
Specific Function Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
Function
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
protein histidine kinase activity
two-component sensor activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
molecular transducer activity
signal transducer activity
protein kinase activity
transporter activity
ion channel activity
cation channel activity
potassium channel activity
voltage-gated potassium channel activity
Process
signaling process
signal transmission
two-component signal transduction system (phosphorelay)
establishment of localization
transport
biological regulation
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
regulation of gene expression
regulation of transcription
regulation of transcription, dna-dependent
regulation of cellular process
signal transduction
transmembrane transport
monovalent inorganic cation transport
potassium ion transport
ion transport
cation transport
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location Chromosome:3
Locus 3p24.3
SNPs KCNH8
Gene Sequence
>3324 bp
ATGCCGGTTATGAAAGGATTACTGGCGCCGCAAAACACCTTCCTGGACACCATCGCCACC
CGTTTTGACGGAACACATAGCAACTTCATCCTTGCCAATGCCCAGGTGGCTAAGGGTTTC
CCCATAGTCTACTGTTCCGATGGCTTCTGCGAGCTTGCTGGATTTGCCCGAACTGAAGTC
ATGCAGAAGAGTTGTAGCTGCAAGTTCTTATTTGGGGTTGAAACCAATGAGCAACTGATG
CTTCAAATAGAAAAGTCACTGGAGGAGAAAACAGAATTCAAAGGAGAAATTATGTTCTAC
AAGAAAAACGGGTCTCCATTTTGGTGCCTACTGGATATTGTTCCCATAAAGAATGAAAAA
GGAGATGTAGTACTTTTTCTGGCCTCGTTCAAAGATATAACAGATACAAAAGTGAAGATT
ACTCCAGAAGATAAAAAAGAAGACAAAGTCAAAGGAAGATCAAGAGCAGGGACCCACTTT
GACTCAGCCCGGAGACGGAGTCGAGCAGTCCTTTATCACATCTCTGGGCACCTGCAAAGA
AGAGAAAAGAACAAATTGAAAATAAATAACAATGTTTTTGTAGATAAACCAGCATTTCCG
GAGTATAAAGTTTCTGATGCAAAAAAGTCCAAATTCATACTTCTGCATTTTAGCACTTTT
AAAGCTGGCTGGGACTGGCTTATTTTGTTGGCAACGTTTTATGTTGCTGTGACTGTACCT
TACAACGTTTGCTTTATTGGCAATGACGACCTGTCCACAACTCGGAGCACAACCGTCAGT
GACATTGCAGTGGAGATTCTTTTTATTATAGATATTATTTTAAATTTCCGAACAACTTAT
GTCAGCAAGTCTGGCCAAGTTATCTTTGAAGCAAGATCAATTTGCATCCACTATGTCACA
ACCTGGTTCATCATTGATTTAATCGCTGCCCTGCCTTTTGATCTTCTGTATGCTTTCAAC
GTCACAGTGGTGTCTCTCGTGCATCTTCTAAAGACAGTGCGCCTCTTGCGTCTTTTGCGT
CTGCTGCAGAAGTTAGACCGCTATTCCCAACACAGTACTATCGTCCTGACTCTGCTCATG
TCCATGTTTGCACTCCTTGCACACTGGATGGCGTGTATCTGGTACGTCATTGGAAAAATG
GAGAGGGAAGACAACAGCCTTCTGAAGTGGGAAGTTGGTTGGCTTCATGAGTTGGGAAAG
AGACTGGAATCTCCATACTATGGCAACAATACCTTGGGGGGCCCGTCGATCCGAAGTGCC
TATATTGCCGCTCTGTACTTCACGCTGAGCAGCCTCACCAGCGTGGGTTTTGGGAACGTC
TCTGCTAATACAGATGCAGAAAAGATCTTCTCCATCTGCACCATGCTGATTGGTGCCTTG
ATGCACGCCTTGGTGTTTGGAAACGTGACAGCAATCATACAGAGGATGTACTCCAGATGG
TCCCTCTATCACACTAGAACTAAGGATCTGAAAGATTTCATCCGTGTCCATCACTTGCCC
CAACAACTCAAGCAGAGGATGCTCGAATATTTTCAAACAACCTGGTCAGTCAACAATGGA
ATAGATTCAAATGAGCTTTTGAAAGACTTTCCAGATGAACTGCGTTCTGACATCACTATG
CACTTGAACAAGGAGATCTTACAGTTGTCCCTTTTTGAATGTGCCAGCCGGGGCTGCCTC
AGGTCTCTGTCTCTACACATCAAAACCTCTTTCTGTGCTCCGGGGGAGTATCTGCTGCGT
CAAGGGGATGCTTTGCAGGCCATCTACTTTGTATGCTCGGGCTCCATGGAAGTTCTTAAA
GACAGCATGGTGCTGGCTATTCTTGGGAAAGGGGATTTAATTGGAGCAAATCTATCAATT
AAGGACCAAGTGATCAAGACCAATGCAGATGTAAAGGCTTTAACCTACTGTGATCTCCAG
TGTATCATCCTCAAAGGACTCTTTGAAGTGCTAGACCTTTACCCAGAATATGCTCACAAA
TTCGTGGAAGACATTCAGCATGACCTCACATACAACCTCCGAGAAGGTCATGAGAGTGAT
GTGATATCAAGACTATCAAACAAATCTATGGTCTCACAGTCAGAGCCCAAGGGAAATGGC
AACATCAACAAGCGACTCCCATCCATTGTGGAAGATGAGGAAGAGGAGGAGGAGGGGGAG
GAAGAGGAGGCAGTCTCCCTCTCTCCCATCTGCACAAGGGGATCTTCTTCGCGCAACAAG
AAGGTTGGAAGCAATAAAGCCTACCTGGGCTTAAGCTTAAAGCAACTGGCCTCGGGAACG
GTGCCCTTTCACTCGCCTATCAGAGTCTCCAGGTCAAATTCCCCCAAAACCAAGCAGGAA
ATTGACCCCCCCAACCATAATAAAAGGAAAGAGAAGAACTTGAAATTGCAACTTTCAACT
TTGAATAATGCTGGACCCCCAGACCTCAGTCCAAGGATTGTTGATGGAATTGAAGATGGA
AACAGCAGTGAAGAAAGTCAGACTTTTGATTTTGGCTCTGAACGAATCAGATCAGAGCCC
AGAATTTCTCCTCCTCTTGGAGATCCAGAGATTGGAGCTGCTGTTCTCTTCATCAAAGCA
GAGGAGACCAAGCAGCAGATAAACAAACTCAACAGTGAGGTAACAACATTGACTCAGGAA
GTTTCTCAGTTGGGTAAAGACATGAGAAATGTGATCCAGCTTCTGGAAAACGTTCTGTCA
CCTCAGCAGCCATCACGGTTTTGCTCTTTGCACAGCACCTCTGTGTGTCCCTCCAGGGAG
AGCTTACAGACCAGAACGAGCTGGAGTGCACACCAGCCTTGCCTACACTTGCAAACAGGC
GGGGCTGCTTATACCCAAGCACAACTTTGTAGCAGTAATATCACCTCAGACATTTGGAGT
GTGGATCCCTCCTCTGTGGGGAGCAGCCCCCAACGAACTGGAGCTCATGAGCAAAATCCT
GCAGACAGTGAACTTTATCATTCTCCAAGCCTTGATTATTCACCTTCCCACTACCAGGTT
GTCCAAGAAGGTCATTTGCAATTTTTAAGGTGCATCTCTCCACATTCAGATTCTACGTTG
ACGCCTCTGCAGTCCATTTCAGCAACTCTCTCATCTTCTGTCTGCTCCTCTTCGGAAACA
TCTTTGCACCTAGTTCTCCCAAGCAGATCAGAGGAGGGCAGCTTCAGTCAGGGAACTGTG
AGTTCCTTCAGTCTGGAAAACTTACCAGGATCTTGGAACCAGGAAGGAATGGCATCAGCT
TCTACAAAACCTTTGGAGAACCTTCCACTGGAAGTTGTCACAAGCACAGCAGAAGTGAAA
GATAACAAAGCCATAAATGTATGA
Protein Properties
Number of Residues 1107
Molecular Weight 123803.1
Theoretical pI 6.91
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 226-246
  • 256-276
  • 299-319
  • 328-348
  • 358-378
  • 449-469
Protein Sequence
>Potassium voltage-gated channel subfamily H member 8
MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEV
MQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEK
GDVVLFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISGHLQR
REKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVP
YNVCFIGNDDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVT
TWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLM
SMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSA
YIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRW
SLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITM
HLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLK
DSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHK
FVEDIQHDLTYNLREGHESDVISRLSNKSMVSQSEPKGNGNINKRLPSIVEDEEEEEEGE
EEEAVSLSPICTRGSSSRNKKVGSNKAYLGLSLKQLASGTVPFHSPIRVSRSNSPKTKQE
IDPPNHNKRKEKNLKLQLSTLNNAGPPDLSPRIVDGIEDGNSSEESQTFDFGSERIRSEP
RISPPLGDPEIGAAVLFIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRNVIQLLENVLS
PQQPSRFCSLHSTSVCPSRESLQTRTSWSAHQPCLHLQTGGAAYTQAQLCSSNITSDIWS
VDPSSVGSSPQRTGAHEQNPADSELYHSPSLDYSPSHYQVVQEGHLQFLRCISPHSDSTL
TPLQSISATLSSSVCSSSETSLHLVLPSRSEEGSFSQGTVSSFSLENLPGSWNQEGMASA
STKPLENLPLEVVTSTAEVKDNKAINV
GenBank ID Protein 27886667
UniProtKB/Swiss-Prot ID Q96L42
UniProtKB/Swiss-Prot Entry Name KCNH8_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_144633.2
GeneCard ID KCNH8
GenAtlas ID KCNH8
HGNC ID HGNC:18864
References
General References
  1. Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA: The DNA sequence, annotation and analysis of human chromosome 3. Nature. 2006 Apr 27;440(7088):1194-8. [PubMed:16641997 ]
  2. Baxter DF, Kirk M, Garcia AF, Raimondi A, Holmqvist MH, Flint KK, Bojanic D, Distefano PS, Curtis R, Xie Y: A novel membrane potential-sensitive fluorescent dye improves cell-based assays for ion channels. J Biomol Screen. 2002 Feb;7(1):79-85. [PubMed:11897058 ]
  3. Zou A, Lin Z, Humble M, Creech CD, Wagoner PK, Krafte D, Jegla TJ, Wickenden AD: Distribution and functional properties of human KCNH8 (Elk1) potassium channels. Am J Physiol Cell Physiol. 2003 Dec;285(6):C1356-66. Epub 2003 Jul 30. [PubMed:12890647 ]