Hmdb loader
Identification
HMDB Protein ID HMDBP08148
Secondary Accession Numbers
  • 13859
Name Leucine zipper putative tumor suppressor 1
Synonyms
  1. F37/esophageal cancer-related gene-coding leucine-zipper motif
  2. Fez1
Gene Name LZTS1
Protein Type Unknown
Biological Properties
General Function Cell cycle control, cell division, chromosome partitioning
Specific Function Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
intracellular part
cytoplasm
Cellular Location
  1. Cell membrane
  2. Cytoplasm
  3. Cell junction
  4. Cell junction
  5. synapse
  6. synapse
  7. Cell projection
  8. dendritic spine
  9. postsynaptic cell membrane
  10. postsynaptic density
Gene Properties
Chromosome Location Chromosome:8
Locus 8p22
SNPs LZTS1
Gene Sequence
>1791 bp
ATGGGCAGCGTCAGTAGCCTCATCTCCGGCCACAGCTTCCACAGCAAGCACTGCCGGGCT
TCGCAGTACAAGCTGCGCAAGTCCTCCCACCTCAAGAAGCTCAACCGGTATTCCGACGGG
CTGCTGAGGTTTGGCTTCTCCCAGGACTCCGGTCACGGCAAGTCCAGCTCCAAAATGGGC
AAGAGCGAAGACTTCTTCTACATCAAGGTCAGCCAGAAAGCCCGGGGCTCCCATCACCCA
GATTACACGGCACTGTCCAGCGGGGATTTAGGGGGCCAGGCTGGGGTGGACTTTGACCCG
TCCACACCCCCCAAGCTCATGCCCTTCTCCAATCAGCTAGAAATGGGCTCCGAGAAGGGT
GCAGTGAGGCCCACAGCCTTCAAGCCTGTGCTGCCACGGTCAGGAGCCATCCTGCACTCC
TCCCCGGAGAGTGCCAGCCACCAGCTGCACCCCGCCCCTCCAGACAAGCCCAAGGAGCAG
GAGCTGAAGCCTGGCCTGTGCTCTGGGGCGCTGTCAGACTCCGGCCGGAACTCCATGTCC
AGCCTGCCCACACACAGCACCAGCAGCAGCTACCAGCTGGACCCGCTGGTCACACCCGTG
GGACCCACAAGCCGTTTTGGGGGCTCCGCCCACAACATCACCCAGGGCATCGTCCTCCAG
GACAGCAACATGATGAGCCTGAAGGCTCTGTCCTTCTCCGACGGAGGTAGCAAGCTGGGC
CACTCGAACAAGGCAGACAAGGGCCCCTCGTGTGTCCGCTCCCCCATCTCCACGGACGAG
TGCAGCATCCAGGAGCTGGAGCAGAAGCTGTTGGAGAGGGAGGGCGCCCTCCAGAAGCTG
CAGCGCAGCTTTGAGGAGAAGGAGCTTGCCTCCAGCCTGGCCTACGAGGAGCGGCCGCGG
CGCTGCAGGGACGAGCTGGAGGGCCCGGAGCCCAAAGGCGGCAACAAGCTCAAGCAGGCC
TCGCAGAAGAGCCAGCGCGCGCAGCAGGTCCTGCACCTGCAGGTACTGCAGCTTCAGCAG
GAGAAGCGGCAGCTCCGGCAGGAGCTCGAGAGCCTCATGAAGGAGCAGGACCTGCTGGAG
ACCAAGCTCAGGTCCTACGAGAGGGAGAAGACCAGCTTCGGCCCCGCGCTGGAGGAGACC
CAGTGGGAGGTGTGCCAGAAGTCAGGCGAGATCTCCCTCCTGAAGCAGCAGCTGAAGGAG
TCCCAGACGGAGGTGAACGCCAAGGCTAGCGAGATCCTGGGTCTCAAGGCACAGCTGAAG
GACACGCGGGGCAAGCTGGAGGGCCTGGAGCTGAGGACCCAGGACCTGGAGGGCGCCCTG
CGCACCAAGGGCCTGGAGCTGGAGGTCTGTGAGAATGAGCTGCAGCGCAAGAAGAACGAG
GCGGAGCTGCTGCGGGAGAAGGTGAACCTGCTGGAGCAGGAGCTGCAGGAGCTGCGGGCC
CAGGCCGCCCTGGCCCGCGACATGGGGCCGCCCACCTTCCCCGAGGACGTCCCTGCCCTG
CAGCGGGAGCTGGAGCGGCTGCGGGCCGAGCTGCGGGAGGAGCGGCAAGGCCATGACCAG
ATGTCCTCGGGCTTCCAGCATGAGCGGCTCGTGTGGAAGGAGGAGAAGGAGAAGGTGATT
CAGTACCAGAAACAGCTGCAGCAGAGCTACGTGGCCATGTACCAGCGGAACCAGCGCCTG
GAGAAGGCCCTGCAGCAGCTGGCACGTGGGGACAGCGCCGGGGAGCCCTTGGAGGTTGAC
CTGGAAGGGGCTGACATCCCCTACGAGGACATCATAGCCACTGAGATCTGA
Protein Properties
Number of Residues 596
Molecular Weight 66612.4
Theoretical pI 7.1
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Leucine zipper putative tumor suppressor 1
MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGHGKSSSKMG
KSEDFFYIKVSQKARGSHHPDYTALSSGDLGGQAGVDFDPSTPPKLMPFSNQLEMGSEKG
AVRPTAFKPVLPRSGAILHSSPESASHQLHPAPPDKPKEQELKPGLCSGALSDSGRNSMS
SLPTHSTSSSYQLDPLVTPVGPTSRFGGSAHNITQGIVLQDSNMMSLKALSFSDGGSKLG
HSNKADKGPSCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPR
RCRDELEGPEPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLE
TKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLK
DTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRA
QAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVI
QYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPYEDIIATEI
GenBank ID Protein 10440566
UniProtKB/Swiss-Prot ID Q9Y250
UniProtKB/Swiss-Prot Entry Name LZTS1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_021020.2
GeneCard ID LZTS1
GenAtlas ID LZTS1
HGNC ID HGNC:13861
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Ishii H, Baffa R, Numata SI, Murakumo Y, Rattan S, Inoue H, Mori M, Fidanza V, Alder H, Croce CM: The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3928-33. [PubMed:10097140 ]
  3. Cabeza-Arvelaiz Y, Sepulveda JL, Lebovitz RM, Thompson TC, Chinault AC: Functional identification of LZTS1 as a candidate prostate tumor suppressor gene on human chromosome 8p22. Oncogene. 2001 Jul 12;20(31):4169-79. [PubMed:11464283 ]
  4. Ishii H, Vecchione A, Murakumo Y, Baldassarre G, Numata S, Trapasso F, Alder H, Baffa R, Croce CM: FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis. Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10374-9. Epub 2001 Aug 14. [PubMed:11504921 ]