| Identification |
|---|
| HMDB Protein ID
| HMDBP08150 |
| Secondary Accession Numbers
| |
| Name
| Mas-related G-protein coupled receptor member D |
| Synonyms
|
- Beta-alanine receptor
- G-protein coupled receptor TGR7
|
| Gene Name
| MRGPRD |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin- stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i) |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Process |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11q13.3 |
| SNPs
| MRGPRD |
| Gene Sequence
|
>966 bp
ATGAACCAGACTTTGAATAGCAGTGGGACCGTGGAGTCAGCCCTAAACTATTCCAGAGGG
AGCACAGTGCACACGGCCTACCTGGTGCTGAGCTCCCTGGCCATGTTCACCTGCCTGTGC
GGGATGGCAGGCAACAGCATGGTGATCTGGCTGCTGGGCTTTCGAATGCACAGGAACCCC
TTCTGCATCTATATCCTCAACCTGGCGGCAGCCGACCTCCTCTTCCTCTTCAGCATGGCT
TCCACGCTCAGCCTGGAAACCCAGCCCCTGGTCAATACCACTGACAAGGTCCACGAGCTG
ATGAAGAGACTGATGTACTTTGCCTACACAGTGGGCCTGAGCCTGCTGACGGCCATCAGC
ACCCAGCGCTGTCTCTCTGTCCTCTTCCCTATCTGGTTCAAGTGTCACCGGCCCAGGCAC
CTGTCAGCCTGGGTGTGTGGCCTGCTGTGGACACTCTGTCTCCTGATGAACGGGTTGACC
TCTTCCTTCTGCAGCAAGTTCTTGAAATTCAATGAAGATCGGTGCTTCAGGGTGGACATG
GTCCAGGCCGCCCTCATCATGGGGGTCTTAACCCCAGTGATGACTCTGTCCAGCCTGACC
CTCTTTGTCTGGGTGCGGAGGAGCTCCCAGCAGTGGCGGCGGCAGCCCACACGGCTGTTC
GTGGTGGTCCTGGCCTCTGTCCTGGTGTTCCTCATCTGTTCCCTGCCTCTGAGCATCTAC
TGGTTTGTGCTCTACTGGTTGAGCCTGCCGCCCGAGATGCAGGTCCTGTGCTTCAGCTTG
TCACGCCTCTCCTCGTCCGTAAGCAGCAGCGCCAACCCCGTCATCTACTTCCTGGTGGGC
AGCCGGAGGAGCCACAGGCTGCCCACCAGGTCCCTGGGGACTGTGCTCCAACAGGCGCTT
CGCGAGGAGCCCGAGCTGGAAGGTGGGGAGACGCCCACCGTGGGCACCAATGAGATGGGG
GCTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 321 |
| Molecular Weight
| 36117.2 |
| Theoretical pI
| 9.04 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- 34-54
- 60-80
- 113-133
- 143-163
- 185-205
- 219-239
- 258-280
|
| Protein Sequence
|
>Mas-related G-protein coupled receptor member D
MNQTLNSSGTVESALNYSRGSTVHTAYLVLSSLAMFTCLCGMAGNSMVIWLLGFRMHRNP
FCIYILNLAAADLLFLFSMASTLSLETQPLVNTTDKVHELMKRLMYFAYTVGLSLLTAIS
TQRCLSVLFPIWFKCHRPRHLSAWVCGLLWTLCLLMNGLTSSFCSKFLKFNEDRCFRVDM
VQAALIMGVLTPVMTLSSLTLFVWVRRSSQQWRRQPTRLFVVVLASVLVFLICSLPLSIY
WFVLYWLSLPPEMQVLCFSLSRLSSSVSSSANPVIYFLVGSRRSHRLPTRSLGTVLQQAL
REEPELEGGETPTVGTNEMGA
|
| External Links |
|---|
| GenBank ID Protein
| 42794265 |
| UniProtKB/Swiss-Prot ID
| Q8TDS7 |
| UniProtKB/Swiss-Prot Entry Name
| MRGRD_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_198923.2 |
| GeneCard ID
| MRGPRD |
| GenAtlas ID
| MRGPRD |
| HGNC ID
| HGNC:29626 |
| References |
|---|
| General References
| - Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S: Identification of G protein-coupled receptor genes from the human genome sequence. FEBS Lett. 2002 Jun 5;520(1-3):97-101. [PubMed:12044878 ]
- Zylka MJ, Dong X, Southwell AL, Anderson DJ: Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10043-8. Epub 2003 Aug 8. [PubMed:12909716 ]
- Shinohara T, Harada M, Ogi K, Maruyama M, Fujii R, Tanaka H, Fukusumi S, Komatsu H, Hosoya M, Noguchi Y, Watanabe T, Moriya T, Itoh Y, Hinuma S: Identification of a G protein-coupled receptor specifically responsive to beta-alanine. J Biol Chem. 2004 May 28;279(22):23559-64. Epub 2004 Mar 22. [PubMed:15037633 ]
|
