Hmdb loader
Identification
HMDB Protein ID HMDBP08164
Secondary Accession Numbers
  • 13875
Name FMRFamide-related peptides
Synonyms
  1. Neuropeptide NPSF
  2. Neuropeptide NPVF
  3. Neuropeptide RFRP-1
  4. Neuropeptide RFRP-2
  5. Neuropeptide RFRP-3
  6. Neuropeptide VF
Gene Name NPVF
Protein Type Unknown
Biological Properties
General Function Involved in G-protein coupled receptor activity
Specific Function Neuropeptides NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP, but RFRP-2 shows no inhibitory activity. Neuropeptide NPSF induces secretion of prolactin in rats. Neuropeptide NPVF blocks morphine-induced analgesia
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Secreted
Gene Properties
Chromosome Location Chromosome:7
Locus 7p21-p15
SNPs NPVF
Gene Sequence
>591 bp
ATGGAAATTATTTCATCAAAACTATTCATTTTATTGACTTTAGCCACTTCAAGCTTGTTA
ACATCAAACATTTTTTGTGCAGATGAATTAGTGATGTCCAATCTTCACAGCAAAGAAAAT
TATGACAAATATTCTGAGCCTAGAGGATACCCAAAAGGGGAAAGAAGCCTCAATTTTGAG
GAATTAAAAGATTGGGGACCAAAAAATGTTATTAAGATGAGTACACCTGCAGTCAATAAA
ATGCCACACTCCTTCGCCAACTTGCCATTGAGATTTGGGAGGAACGTTCAAGAAGAAAGA
AGTGCTGGAGCAACAGCCAACCTGCCTCTGAGATCTGGAAGAAATATGGAGGTGAGCCTC
GTGAGACGTGTTCCTAACCTGCCCCAAAGGTTTGGGAGAACAACAACAGCCAAAAGTGTC
TGCAGGATGCTGAGTGATTTGTGTCAAGGATCCATGCATTCACCATGTGCCAATGACTTA
TTTTACTCCATGACCTGCCAGCACCAAGAAATCCAGAATCCCGATCAAAAACAGTCAAGG
AGACTGCTATTCAAGAAAATAGATGATGCAGAATTGAAACAAGAAAAATAA
Protein Properties
Number of Residues 196
Molecular Weight 22326.4
Theoretical pI 9.52
Pfam Domain Function Not Available
Signals
  • 1-26
Transmembrane Regions
  • None
Protein Sequence
>FMRFamide-related peptides
MEIISSKLFILLTLATSSLLTSNIFCADELVMSNLHSKENYDKYSEPRGYPKGERSLNFE
ELKDWGPKNVIKMSTPAVNKMPHSFANLPLRFGRNVQEERSAGATANLPLRSGRNMEVSL
VRRVPNLPQRFGRTTTAKSVCRMLSDLCQGSMHSPCANDLFYSMTCQHQEIQNPDQKQSR
RLLFKKIDDAELKQEK
GenBank ID Protein 11125708
UniProtKB/Swiss-Prot ID Q9HCQ7
UniProtKB/Swiss-Prot Entry Name RFRP_HUMAN
PDB IDs Not Available
GenBank Gene ID AB040290
GeneCard ID NPVF
GenAtlas ID NPVF
HGNC ID HGNC:13782
References
General References
  1. Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Dohner H, Dohner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, Tsui LC: Human chromosome 7: DNA sequence and biology. Science. 2003 May 2;300(5620):767-72. Epub 2003 Apr 10. [PubMed:12690205 ]
  2. Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-McPherson C, Layman D, Maas J, Jaeger S, Walker R, Wylie K, Sekhon M, Becker MC, O'Laughlin MD, Schaller ME, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Cordes M, Du H, Sun H, Edwards J, Bradshaw-Cordum H, Ali J, Andrews S, Isak A, Vanbrunt A, Nguyen C, Du F, Lamar B, Courtney L, Kalicki J, Ozersky P, Bielicki L, Scott K, Holmes A, Harkins R, Harris A, Strong CM, Hou S, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Leonard S, Rohlfing T, Rock SM, Tin-Wollam AM, Abbott A, Minx P, Maupin R, Strowmatt C, Latreille P, Miller N, Johnson D, Murray J, Woessner JP, Wendl MC, Yang SP, Schultz BR, Wallis JW, Spieth J, Bieri TA, Nelson JO, Berkowicz N, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Bedell JA, Mardis ER, Clifton SW, Chissoe SL, Marra MA, Raymond C, Haugen E, Gillett W, Zhou Y, James R, Phelps K, Iadanoto S, Bubb K, Simms E, Levy R, Clendenning J, Kaul R, Kent WJ, Furey TS, Baertsch RA, Brent MR, Keibler E, Flicek P, Bork P, Suyama M, Bailey JA, Portnoy ME, Torrents D, Chinwalla AT, Gish WR, Eddy SR, McPherson JD, Olson MV, Eichler EE, Green ED, Waterston RH, Wilson RK: The DNA sequence of human chromosome 7. Nature. 2003 Jul 10;424(6945):157-64. [PubMed:12853948 ]
  3. Hinuma S, Shintani Y, Fukusumi S, Iijima N, Matsumoto Y, Hosoya M, Fujii R, Watanabe T, Kikuchi K, Terao Y, Yano T, Yamamoto T, Kawamata Y, Habata Y, Asada M, Kitada C, Kurokawa T, Onda H, Nishimura O, Tanaka M, Ibata Y, Fujino M: New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat Cell Biol. 2000 Oct;2(10):703-8. [PubMed:11025660 ]
  4. Schulz HL, Stoehr H, White K, van Driel MA, Hoyng CB, Cremers F, Weber BH: Genomic structure and assessment of the retinally expressed RFamide-related peptide gene in dominant cystoid macular dystrophy. Mol Vis. 2002 Mar 19;8:67-71. [PubMed:11951088 ]
  5. Liu Q, Guan XM, Martin WJ, McDonald TP, Clements MK, Jiang Q, Zeng Z, Jacobson M, Williams DL Jr, Yu H, Bomford D, Figueroa D, Mallee J, Wang R, Evans J, Gould R, Austin CP: Identification and characterization of novel mammalian neuropeptide FF-like peptides that attenuate morphine-induced antinociception. J Biol Chem. 2001 Oct 5;276(40):36961-9. Epub 2001 Jul 31. [PubMed:11481330 ]