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Identification
HMDB Protein ID HMDBP08191
Secondary Accession Numbers
  • 13902
Name Chloride intracellular channel protein 2
Synonyms
  1. XAP121
Gene Name CLIC2
Protein Type Unknown
Biological Properties
General Function Involved in electron carrier activity
Specific Function Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx
Pathways
  • Betazole Action Pathway
  • Cimetidine Action Pathway
  • Esomeprazole Action Pathway
  • Famotidine Action Pathway
  • Gastric Acid Production
  • Lafutidine H2-Antihistamine Action
  • Lansoprazole Action Pathway
  • Metiamide Action Pathway
  • Nizatidine Action Pathway
  • Omeprazole Action Pathway
  • Pantoprazole Action Pathway
  • Pirenzepine Action Pathway
  • Rabeprazole Action Pathway
  • Ranitidine Action Pathway
  • Roxatidine acetate Action Pathway
Reactions Not Available
GO Classification
Component
membrane
cell part
Function
voltage-gated chloride channel activity
catalytic activity
electron carrier activity
anion channel activity
chloride channel activity
oxidoreductase activity, acting on a sulfur group of donors
disulfide oxidoreductase activity
protein disulfide oxidoreductase activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
oxidoreductase activity
transporter activity
ion channel activity
Process
establishment of localization
cellular process
transport
chloride transport
anion transport
inorganic anion transport
cellular homeostasis
cell redox homeostasis
ion transport
Cellular Location
  1. Cytoplasm
  2. Membrane
  3. Single-pass membrane protein (Probable)
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs CLIC2
Gene Sequence
>744 bp
ATGTCAGGCCTGCGGCCCGGCACTCAAGTGGACCCTGAGATTGAGCTTTTTGTAAAGGCT
GGAAGTGATGGAGAGAGTATTGGAAACTGTCCCTTTTGCCAACGCCTTTTCATGATCCTC
TGGCTTAAAGGAGTTAAATTTAATGTGACAACTGTTGACATGACCAGAAAGCCTGAAGAA
CTAAAGGACTTAGCCCCAGGTACCAATCCTCCGTTCCTGGTGTATAACAAGGAGTTGAAA
ACAGACTTCATTAAAATTGAGGAGTTTTTAGAACAAACCCTGGCTCCTCCAAGGTACCCT
CACCTGAGTCCCAAGTACAAGGAGTCTTTTGATGTGGGCTGTAACCTCTTTGCCAAGTTT
TCTGCATACATTAAGAATACACAAAAGGAGGCAAATAAGAATTTTGAAAAATCTCTGCTC
AAAGAATTCAAGCGTCTGGATGACTACTTAAACACCCCACTTCTGGATGAAATTGATCCA
GACAGTGCTGAGGAACCCCCAGTTTCCAGAAGACTATTCTTGGATGGGGACCAGCTAACA
CTGGCTGATTGTAGCTTGTTACCCAAGCTGAACATTATTAAAGTTGCTGCCAAGAAATAT
CGTGACTTTGACATTCCAGCAGAATTCTCAGGAGTCTGGCGTTATCTCCACAATGCCTAT
GCCCGTGAAGAATTTACCCACACGTGTCCTGAAGACAAAGAAATTGAAAATACTTACGCA
AATGTGGCTAAACAGAAGAGTTAG
Protein Properties
Number of Residues 247
Molecular Weight 28356.1
Theoretical pI 5.26
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 32-52
Protein Sequence
>Chloride intracellular channel protein 2
MSGLRPGTQVDPEIELFVKAGSDGESIGNCPFCQRLFMILWLKGVKFNVTTVDMTRKPEE
LKDLAPGTNPPFLVYNKELKTDFIKIEEFLEQTLAPPRYPHLSPKYKESFDVGCNLFAKF
SAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLT
LADCSLLPKLNIIKVAAKKYRDFDIPAEFSGVWRYLHNAYAREEFTHTCPEDKEIENTYA
NVAKQKS
GenBank ID Protein 66346733
UniProtKB/Swiss-Prot ID O15247
UniProtKB/Swiss-Prot Entry Name CLIC2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001289.4
GeneCard ID CLIC2
GenAtlas ID CLIC2
HGNC ID HGNC:2063
References
General References
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  4. Fan L, Yu W, Zhu X: Interaction of Sedlin with chloride intracellular channel proteins. FEBS Lett. 2003 Apr 10;540(1-3):77-80. [PubMed:12681486 ]
  5. Heiss NS, Poustka A: Genomic structure of a novel chloride channel gene, CLIC2, in Xq28. Genomics. 1997 Oct 1;45(1):224-8. [PubMed:9339381 ]
  6. Board PG, Coggan M, Watson S, Gage PW, Dulhunty AF: CLIC-2 modulates cardiac ryanodine receptor Ca2+ release channels. Int J Biochem Cell Biol. 2004 Aug;36(8):1599-612. [PubMed:15147738 ]
  7. Dulhunty AF, Pouliquin P, Coggan M, Gage PW, Board PG: A recently identified member of the glutathione transferase structural family modifies cardiac RyR2 substate activity, coupled gating and activation by Ca2+ and ATP. Biochem J. 2005 Aug 15;390(Pt 1):333-43. [PubMed:15916532 ]
  8. Cromer BA, Gorman MA, Hansen G, Adams JJ, Coggan M, Littler DR, Brown LJ, Mazzanti M, Breit SN, Curmi PM, Dulhunty AF, Board PG, Parker MW: Structure of the Janus protein human CLIC2. J Mol Biol. 2007 Nov 30;374(3):719-31. Epub 2007 Sep 20. [PubMed:17945253 ]
  9. Mi W, Liang YH, Li L, Su XD: The crystal structure of human chloride intracellular channel protein 2: a disulfide bond with functional implications. Proteins. 2008 Apr;71(1):509-13. doi: 10.1002/prot.21922. [PubMed:18186468 ]