Showing Protein Sodium-dependent neutral amino acid transporter B(0)AT1 (HMDBP08226)

• 13938

1. Solute carrier family 6 member 19
2. System B(0) neutral amino acid transporter AT1

• Mineral absorption
• Protein digestion and absorption

1. Membrane
2. Multi-pass membrane protein (Probable)

>1905 bp
ATGGTGAGGCTCGTGCTGCCCAACCCCGGCCTAGACGCCCGGATCCCGTCCCTGGCTGAG
CTGGAGACCATCGAGCAGGAGGAGGCCAGCTCCCGGCCGAAGTGGGACAACAAGGCGCAG
TACATGCTCACCTGCCTGGGCTTCTGCGTGGGCCTCGGCAACGTGTGGCGCTTCCCCTAC
CTGTGTCAGAGCCACGGAGGAGGAGCCTTCATGATCCCGTTCCTCATCCTGCTGGTCCTG
GAGGGCATCCCCCTGCTGTACCTGGAGTTCGCCATCGGGCAGCGGCTGCGGCGGGGCAGC
CTGGGTGTGTGGAGCTCCATCCACCCGGCCCTGAAGGGCCTAGGCCTGGCCTCCATGCTC
ACGTCCTTCATGGTGGGACTGTATTACAACACCATCATCTCCTGGATCATGTGGTACTTA
TTCAACTCCTTCCAGGAGCCTCTGCCCTGGAGCGACTGCCCGCTCAACGAGAACCAGACA
GGGTATGTGGACGAGTGCGCCAGGAGCTCCCCTGTGGACTACTTCTGGTACCGAGAGACG
CTCAACATCTCCACGTCCATCAGCGACTCGGGCTCCATCCAGTGGTGGATGCTGCTGTGC
CTGGCCTGCGCATGGAGCGTCCTGTACATGTGCACCATCCGCGGCATCGAGACCACCGGG
AAGGCCGTGTACATCACCTCCACGCTGCCCTATGTCGTCCTGACCATCTTCCTCATCCGA
GGCCTGACGCTGAAGGGCGCCACCAATGGCATCGTCTTCCTCTTCACGCCCAACGTCACG
GAGCTGGCCCAGCCGGACACCTGGCTGGACGCGGGCGCACAGGTCTTCTTCTCCTTCTCC
CTGGCCTTCGGGGGCCTCATCTCCTTCTCCAGCTACAACTCTGTGCACAACAACTGCGAG
AAGGACTCGGTGATTGTGTCCATCATCAACGGCTTCACATCGGTGTATGTGGCCATCGTG
GTCTACTCCGTCATTGGGTTCCGCGCCACGCAGCGCTACGACGACTGCTTCAGCACGAAC
ATCCTGACCCTCATCAACGGGTTCGACCTGCCTGAAGGCAACGTGACCCAGGAGAACTTT
GTGGACATGCAGCAGCGGTGCAACGCCTCCGACCCCGCGGCCTACGCGCAGCTGGTGTTC
CAGACCTGCGACATCAACGCCTTCCTCTCAGAGGCCGTGGAGGGCACAGGCCTGGCCTTC
ATCGTCTTCACCGAGGCCATCACCAAGATGCCGTTGTCCCCACTGTGGTCTGTGCTCTTC
TTCATTATGCTCTTCTGCCTGGGGCTGTCATCTATGTTTGGGAACATGGAGGGCGTCGTT
GTGCCCCTGCAGGACCTCAGAGTCATCCCCCCGAAGTGGCCCAAGGAGGTGCTCACAGGC
CTCATCTGCCTGGGGACATTCCTCATTGGCTTCATCTTCACGCTGAACTCCGGCCAGTAC
TGGCTCTCCCTGCTGGACAGCTATGCCGGCTCCATTCCCCTGCTCATCATCGCCTTCTGC
GAGATGTTCTCTGTGGTCTACGTGTACGGTGTGGACAGGTTCAATAAGGACATCGAGTTC
ATGATCGGCCACAAGCCCAACATCTTCTGGCAAGTCACGTGGCGCGTGGTCAGCCCCCTG
CTCATGCTGATCATCTTCCTCTTCTTCTTCGTGGTAGAGGTCAGTCAGGAGCTGACCTAC
AGCATCTGGGACCCTGGCTACGAGGAATTTCCCAAATCCCAGAAGATCTCCTACCCGAAC
TGGGTGTATGTGGTGGTGGTGATTGTGGCTGGAGTGCCCTCCCTCACCATCCCTGGCTAT
GCCATCTACAAGCTCATCAGGAACCACTGCCAGAAGCCAGGGGACCATCAGGGGCTGGTG
AGCACACTGTCCACAGCCTCCATGAACGGGGACCTGAAGTACTGA

• SNF (PF00209 )

>Sodium-dependent neutral amino acid transporter B(0)AT1
MVRLVLPNPGLDARIPSLAELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPY
LCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASML
TSFMVGLYYNTIISWIMWYLFNSFQEPLPWSDCPLNENQTGYVDECARSSPVDYFWYRET
LNISTSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIR
GLTLKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCE
KDSVIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENF
VDMQQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLF
FIMLFCLGLSSMFGNMEGVVVPLQDLRVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQY
WLSLLDSYAGSIPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPL
LMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGY
AIYKLIRNHCQKPGDHQGLVSTLSTASMNGDLKY

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2. Kleta R, Romeo E, Ristic Z, Ohura T, Stuart C, Arcos-Burgos M, Dave MH, Wagner CA, Camargo SR, Inoue S, Matsuura N, Helip-Wooley A, Bockenhauer D, Warth R, Bernardini I, Visser G, Eggermann T, Lee P, Chairoungdua A, Jutabha P, Babu E, Nilwarangkoon S, Anzai N, Kanai Y, Verrey F, Gahl WA, Koizumi A: Mutations in SLC6A19, encoding B0AT1, cause Hartnup disorder. Nat Genet. 2004 Sep;36(9):999-1002. Epub 2004 Aug 1. [PubMed:15286787 ]
3. Seow HF, Broer S, Broer A, Bailey CG, Potter SJ, Cavanaugh JA, Rasko JE: Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19. Nat Genet. 2004 Sep;36(9):1003-7. Epub 2004 Aug 1. [PubMed:15286788 ]