Hmdb loader
Identification
HMDB Protein ID HMDBP08228
Secondary Accession Numbers
  • 13940
Name Protein tweety homolog 1
Synonyms
  1. hTTY1
Gene Name TTYH1
Protein Type Unknown
Biological Properties
General Function Involved in chloride channel activity
Specific Function Isoform 3 may be a Ca(2+)-independent and swelling- activated chloride channel, possibly involved in regulation of cell volume
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Cell membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location Chromosome:1
Locus 19q13.4
SNPs TTYH1
Gene Sequence
>1353 bp
ATGGGGGCGCCCCCGGGCTACCGGCCCTCAGCTTGGGTGCATCTCCTCCACCAGCTGCCC
CGCGCCGACTTCCAGCTCCGCCCGGTGCCCAGCGTTTTCGCGCCCCAAGAGCAGGAATAC
CAGCAGGCCTTGTTGCTGGTGGCGGCCTTGGCGGGCCTGGGCTTGGGCCTGAGCCTCATT
TTCATCGCTGTCTACCTCATCCGCTTCTGCTGCTGCCGGCCCCCCGAGCCCCCCGGGTCC
AAGATCCCCTCGCCCGGGGGAGGCTGCGTCACCTGGAGCTGCATTGTCGCCCTTCTCGCC
GGCTGCACTGGCATTGGCATCGGTTTCTATGGCAACAGTGAGACCAGTGATGGGGTGTCC
CAGCTCAGCTCTGCGCTGCTGCACGCCAACCACACACTCAGCACCATTGACCACCTGGTG
TTGGAGACGGTGGAGAGGCTGGGCGAGGCGGTGAGGACAGAGCTGACCACCCTGGAGGAG
GTGCTCGAGCCGCGCACGGAGCTGGTGGCTGCCGCCCGAGGGGCTCGACGGCAGGCGGAG
GCTGCGGCCCAGCAGCTGCAGGGGCTGGCCTTCTGGCAGGGAGTGCCCCTGAGCCCCCTG
CAGGTGGCTGAAAATGTGTCCTTTGTGGAGGAGTACAGGTGGCTGGCCTACGTCCTCCTG
CTGCTCCTGGAGCTGCTGGTCTGCCTCTTCACCCTCCTGGGCCTGGCGAAGCAGAGCAAG
TGGCTGGTGATCGTGATGACAGTCATGAGTCTCCTGGTTCTCGTCCTGAGCTGGGGCTCC
ATGGGCCTGGAGGCAGCCACGGCCGTGGGCCTCAGTGACTTCTGCTCCAATCCAGACCCT
TATGTTCTGAACCTGACCCAGGAGGAGACAGGGCTCAGCTCAGACATCCTGAGCTATTAT
CTCCTCTGCAACCGGGCCGTCTCCAACCCCTTCCAACAGAGGCTGACTCTGTCCCAGCGA
GCTCTGGCCAACATCCACTCCCAGCTGCTGGGCCTGGAGCGAGAAGCTGTGCCTCAGTTC
CCTTCAGCGCAGAAGCCTCTGCTGTCCTTGGAGGAGACTCTGAATGTGACAGAAGGAAAT
TTCCACCAGTTGGTGGCACTGCTACACTGCCGCAGCCTGCACAAGGACTATGGTGCAGCC
CTGCGGGGCCTGTGCGAAGACGCCCTGGAAGGCCTGCTCTTCCTGCTACTCTTCTCCCTG
CTGTCTGCAGGAGCGCTGGCCACTGCCCTCTGCAGCCTGCCCCGAGCCTGGGCCCTCTTC
CCACCCAGTGACGACTACGATGACACAGACGATGACGACCCTTTCAACCCTCAGGAATCC
AAGCGCTTTGTGCAGTGGCAGTCGTCTATCTGA
Protein Properties
Number of Residues 450
Molecular Weight 49050.0
Theoretical pI 4.62
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 44-64
  • 89-109
  • 215-235
  • 241-261
  • 391-411
Protein Sequence
>Protein tweety homolog 1
MGAPPGYRPSAWVHLLHQLPRADFQLRPVPSVFAPQEQEYQQALLLVAALAGLGLGLSLI
FIAVYLIRFCCCRPPEPPGSKIPSPGGGCVTWSCIVALLAGCTGIGIGFYGNSETSDGVS
QLSSALLHANHTLSTIDHLVLETVERLGEAVRTELTTLEEVLEPRTELVAAARGARRQAE
AAAQQLQGLAFWQGVPLSPLQVAENVSFVEEYRWLAYVLLLLLELLVCLFTLLGLAKQSK
WLVIVMTVMSLLVLVLSWGSMGLEAATAVGLSDFCSNPDPYVLNLTQEETGLSSDILSYY
LLCNRAVSNPFQQRLTLSQRALANIHSQLLGLEREAVPQFPSAQKPLLSLEETLNVTEGN
FHQLVALLHCRSLHKDYGAALRGLCEDALEGLLFLLLFSLLSAGALATALCSLPRAWALF
PPSDDYDDTDDDDPFNPQESKRFVQWQSSI
GenBank ID Protein 10257437
UniProtKB/Swiss-Prot ID Q9H313
UniProtKB/Swiss-Prot Entry Name TTYH1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_020659.2
GeneCard ID TTYH1
GenAtlas ID TTYH1
HGNC ID HGNC:13476
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM: The DNA sequence and biology of human chromosome 19. Nature. 2004 Apr 1;428(6982):529-35. [PubMed:15057824 ]
  4. Campbell HD, Kamei M, Claudianos C, Woollatt E, Sutherland GR, Suzuki Y, Hida M, Sugano S, Young IG: Human and mouse homologues of the Drosophila melanogaster tweety (tty) gene: a novel gene family encoding predicted transmembrane proteins. Genomics. 2000 Aug 15;68(1):89-92. [PubMed:10950931 ]
  5. Suzuki M, Mizuno A: A novel human Cl(-) channel family related to Drosophila flightless locus. J Biol Chem. 2004 May 21;279(21):22461-8. Epub 2004 Mar 8. [PubMed:15010458 ]
  6. Matthews CA, Shaw JE, Hooper JA, Young IG, Crouch MF, Campbell HD: Expression and evolution of the mammalian brain gene Ttyh1. J Neurochem. 2007 Feb;100(3):693-707. Epub 2006 Nov 20. [PubMed:17116230 ]