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Identification
HMDB Protein ID HMDBP08247
Secondary Accession Numbers
  • 13959
Name Hephaestin
Synonyms Not Available
Gene Name HEPH
Protein Type Unknown
Biological Properties
General Function Involved in copper ion binding
Specific Function May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
transition metal ion binding
oxidoreductase activity
copper ion binding
Process
metabolic process
oxidation reduction
Cellular Location
  1. Membrane
  2. Single-pass type I membrane protein (Potential)
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs HEPH
Gene Sequence
>3477 bp
ATGGAGTCAGGCCACCTCCTCTGGGCTCTGCTGTTCATGCAGTCCTTGTGGCCTCAACTG
ACTGATGGAGCCACTCGAGTCTACTACCTGGGCATCCGGGATGTGCAGTGGAACTATGCT
CCCAAGGGAAGAAATGTCATCACGAACCAGCCTCTGGACAGTGACATAGTGGCTTCCAGC
TTCTTAAAGTCTGACAAGAACCGGATAGGGGGAACCTACAAGAAGACCATCTATAAAGAA
TACAAGGATGACTCATACACAGATGAAGTGGCCCAGCCTGCCTGGTTGGGCTTCCTGGGG
CCAGTGTTGCAGGCTGAAGTGGGGGATGTCATTCTTATTCACCTGAAGAATTTTGCCACT
CGTCCCTATACCATCCACCCTCATGGTGTCTTCTACGAGAAGGACTCTGAAGGTTCCCTA
TACCCAGATGGCTCCTCTGGGCCACTGAAAGCTGATGACTCTGTTCCCCCGGGGGGCAGC
CATATCTACAACTGGACCATTCCAGAAGGCCATGCACCCACCGATGCTGACCCAGCGTGC
CTCACCTGGATCTACCATTCTCATGTAGATGCTCCACGAGACATTGCAACTGGCCTAATT
GGGCCTCTCATCACCTGTAAAAGAGGAGCCCTGGATGGGAACTCCCCTCCTCAACGCCAG
GATGTAGACCATGATTTCTTCCTCCTCTTCAGTGTGGTAGATGAGAACCTCAGCTGGCAT
CTCAATGAGAACATTGCCACTTACTGCTCAGATCCTGCTTCAGTGGACAAAGAAGATGAG
ACATTTCAGGAGAGCAATAGGATGCATGCAATCAATGGCTTTGTTTTTGGGAATTTACCT
GAGCTGAACATGTGTGCACAGAAACGTGTGGCCTGGCACTTGTTTGGCATGGGCAATGAA
ATTGATGTCCACACAGCATTTTTCCATGGACAGATGCTGACTACCCGTGGACACCACACT
GATGTGGCTAACATCTTTCCAGCCACCTTTGTGACTGCTGAGATGGTGCCCTGGGAACCT
GGTACCTGGTTAATTAGCTGCCAAGTGAACAGTCACTTTCGAGATGGCATGCAGGCACTC
TACAAGGTCAAGTCTTGCTCCATGGCCCCTCCTGTGGACCTGCTCACAGGCAAAGTTCGA
CAGTACTTCATTGAGGCCCATGAGATTCAATGGGACTATGGCCCGATGGGGCATGATGGG
AGTACTGGGAAGAATTTGAGAGAGCCAGGCAGTATCTCAGATAAGTTTTTCCAGAAGAGC
TCCAGCCGAATTGGGGGCACTTACTGGAAAGTGCGATATGAAGCCTTTCAAGATGAGACA
TTCCAAGAGAAGATGCATTTGGAGGAAGATAGGCATCTTGGAATCCTGGGGCCAGTGATC
CGGGCTGAGGTGGGTGACACCATTCAGGTGGTCTTCTACAACCGTGCCTCCCAGCCATTC
AGCATGCAGCCCCATGGGGTCTTTTATGAGAAAGACTATGAAGGCACTGTGTACAATGAT
GGCTCATCTTACCCTGGCTTGGTTGCCAAGCCCTTTGAGAAAGTAACATACCGCTGGACA
GTCCCCCCTCATGCCGGTCCCACTGCTCAGGATCCTGCTTGTCTCACTTGGATGTACTTC
TCTGCTGCAGATCCCATAAGAGACACAAATTCTGGCCTGGTGGGCCCGCTGCTGGTGTGC
AGGGCTGGTGCCTTGGGTGCAGATGGCAAGCAGAAAGGGGTGGATAAAGAATTCTTTCTT
CTCTTCACTGTGTTGGATGAGAACAAGAGCTGGTACAGCAATGCCAATCAAGCAGCTGCT
ATGTTGGATTTCCGACTGCTTTCAGAGGATATTGAGGGCTTCCAAGACTCCAATCGGATG
CATGCCATTAATGGGTTTCTGTTCTCTAACCTGCCCAGGCTGGACATGTGCAAGGGTGAC
ACAGTGGCCTGGCACCTGCTCGGCCTGGGCACAGAGACTGATGTGCATGGAGTCATGTTC
CAGGGCAACACTGTGCAGCTTCAGGGCATGAGGAAGGGTGCAGCTATGCTCTTTCCTCAT
ACCTTTGTCATGGCCATCATGCAGCCTGACAACCTTGGGACATTTGAGATTTATTGCCAG
GCAGGCAGCCATCGAGAAGCAGGGATGAGGGCAATCTATAATGTCTCCCAGTGTCCTGGC
CACCAAGCCACCCCTCGCCAACGCTACCAAGCTGCAAGAATCTACTATATCATGGCAGAA
GAAGTAGAGTGGGACTATTGCCCTGACCGGAGCTGGGAACGGGAATGGCACAACCAGTCT
GAGAAGGACAGTTATGGTTACATTTTCCTGAGCAACAAGGATGGGCTCCTGGGTTCCAGA
TACAAGAAAGCTGTATTCAGGGAATACACTGATGGTACATTCAGGATCCCTCGGCCAAGG
ACTGGACCAGAAGAACACTTGGGAATCTTGGGTCCACTTATCAAAGGTGAAGTTGGTGAT
ATCCTGACTGTGGTATTCAAGAATAATGCCAGCCGCCCCTACTCTGTGCATGCTCATGGA
GTGCTAGAATCTACTACTGTCTGGCCACTGGCTGCTGAGCCTGGTGAGGTGGTCACTTAT
CAGTGGAACATCCCAGAGAGGTCTGGCCCTGGGCCCAATGACTCTGCTTGTGTTTCCTGG
ATCTATTATTCTGCAGTGGATCCCATCAAGGACATGTATAGTGGCCTGGTGGGGCCCTTG
GCTATCTGCCAAAAGGGCATCCTGGAGCCCCATGGAGGACGGAGTGACATGGATCGGGAA
TTTGCATTGTTGTTCTTGATTTTTGATGAAAATAAGTCTTGGTATTTGGAGGAAAATGTG
GCAACCCATGGGTCCCAGGATCCAGGCAGTATTAACCTACAGGATGAAACTTTCTTGGAG
AGCAATAAAATGCATGCAATCAATGGGAAACTCTATGCCAACCTTAGGGGTCTTACCATG
TACCAAGGAGAACGAGTGGCCTGGTACATGCTGGCCATGGGCCAAGATGTGGATCTACAC
ACCATCCACTTTCATGCAGAGAGCTTCCTCTATCGGAATGGCGAGAACTACCGGGCAGAT
GTGGTGGATCTGTTCCCAGGGACTTTTGAGGTTGTGGAGATGGTGGCCAGCAACCCTGGG
ACATGGCTGATGCACTGCCATGTGACTGACCATGTCCATGCTGGCATGGAGACCCTCTTC
ACTGTTTTTTCTCGAACAGAACACTTAAGCCCTCTCACCGTCATCACCAAAGAGACTGAA
AAAGCAGTGCCCCCCAGAGACATTGAAGAAGGCAATGTGAAGATGCTGGGCATGCAGATC
CCCATAAAGAATGTTGAGATGCTGGCCTCTGTTTTGGTTGCCATTAGTGTCACCCTTCTG
CTCGTTGTTCTGGCTCTTGGTGGAGTGGTTTGGTACCAACATCGACAGAGAAAGCTACGA
CGCAATAGGAGGTCCATCCTGGATGACAGCTTCAAGCTTCTGTCTTTCAAACAGTAA
Protein Properties
Number of Residues 1158
Molecular Weight 130447.8
Theoretical pI 5.89
Pfam Domain Function
Signals
  • 1-23
Transmembrane Regions
  • 1111-1131
Protein Sequence
>Hephaestin
MESGHLLWALLFMQSLWPQLTDGATRVYYLGIRDVQWNYAPKGRNVITNQPLDSDIVASS
FLKSDKNRIGGTYKKTIYKEYKDDSYTDEVAQPAWLGFLGPVLQAEVGDVILIHLKNFAT
RPYTIHPHGVFYEKDSEGSLYPDGSSGPLKADDSVPPGGSHIYNWTIPEGHAPTDADPAC
LTWIYHSHVDAPRDIATGLIGPLITCKRGALDGNSPPQRQDVDHDFFLLFSVVDENLSWH
LNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNE
IDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQAL
YKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKS
SSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPF
SMQPHGVFYEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYF
SAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAA
MLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMF
QGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPG
HQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSR
YKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHG
VLESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPL
AICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETFLE
SNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYRAD
VVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITKETE
KAVPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQRKLR
RNRRSILDDSFKLLSFKQ
GenBank ID Protein 12830539
UniProtKB/Swiss-Prot ID Q9BQS7
UniProtKB/Swiss-Prot Entry Name HEPH_HUMAN
PDB IDs Not Available
GenBank Gene ID AF148860
GeneCard ID HEPH
GenAtlas ID HEPH
HGNC ID HGNC:4866
References
General References
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