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Identification
HMDB Protein ID HMDBP08267
Secondary Accession Numbers
  • 13979
Name tRNA-dihydrouridine synthase 3-like
Synonyms Not Available
Gene Name DUS3L
Protein Type Unknown
Biological Properties
General Function Involved in catalytic activity
Specific Function Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs
Pathways Not Available
Reactions Not Available
GO Classification
Function
oxidoreductase activity, acting on the ch-ch group of donors
ion binding
cation binding
metal ion binding
binding
catalytic activity
transition metal ion binding
zinc ion binding
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
nucleic acid binding
oxidoreductase activity
fad or fadh2 binding
trna dihydrouridine synthase activity
Process
rna metabolic process
ncrna metabolic process
trna metabolic process
trna processing
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
oxidation reduction
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location Chromosome:1
Locus 19p13.3
SNPs DUS3L
Gene Sequence
>1953 bp
ATGGCGGAGGGAACGGCGGAGGCTCCTCTAGAGAATGGTGGTGGTGGCGACTCGGGAGCC
GGAGCTTTGGAACGAGGAGTGGCGCCCATTAAGCGTCAATACCTCACCACCAAGGAGCAG
TTTCACCAATTCCTGGAAGCCAAAGGGCAGGAGAAGACTTGCCGGGAAACCGAGGTAGGA
GACCCTGCTGGCAATGAGCTGGCTGAGCCTGAGGCTAAGCGGATCCGACTGGAGGATGGA
CAGACGGCGGACGGGCAGACGGAGGAGGCAGCAGAGCCCGGGGAGCAGCTACAGACTCAG
AAGAGGGCCCGGGGACAAAACAAGGGCCGGCCCCATGTGAAGCCCACGAACTACGACAAG
AACAGGCTGTGTCCCTCCCTAATCCAGGAGTCGGCTGCTAATTGTTTCTTCGGTGATCGC
TGCCGCTTTCTGCACGACGTGGGGCGCTACCTGGAGACCAAGCCGGCCGACCTGGGCCCC
CGCTGCGTGCTCTTCGAGACCTTCGGCCGGTGCCCCTACGGCGTGACCTGCCGCTTCGCT
GGGGCCCACCTGAGGCCCGAGGGACAGAACCTGGTGCAGGAGGAGTTGGCGGCCCGCGGG
ACCCAGCCCCCGTCCATCCGCAACGGCCTGGACAAAGCCCTGCAGCAGCAGCTGCGGAAG
CGCGAGGTCCGCTTCGAGCGAGCTGAGCAGGCCCTGCGCCGGTTCAGCCAGGGCCCCACA
CCCGCTGCCGCTGTCCCCGAGGGCACGGCAGCCGAGGGCGCTCCCAGGCAGGAAAACTGT
GGTGCCCAGCAGGTCCCCGCAGGGCCGGGCACTAGCACCCCTCCCAGCAGCCCCGTGCGG
ACCTGCGGGCCCCTGACGGATGAGGACGTGGTCAGGCTGCGGCCCTGTGAGAAGAAGCGG
CTGGACATCCGTGGCAAACTTTACCTGGCCCCCCTCACCACGTGTGGGAACCTGCCCTTC
CGACGGATCTGCAAGCGCTTCGGGGCGGATGTGACATGTGGAGAGATGGCCGTCTGCACC
AACCTGCTGCAGGGCCAGATGTCCGAGTGGGCCCTACTCAAACGCCACCAGTGTGAGGAC
ATCTTTGGCGTCCAGCTGGAGGGCGCCTTCCCCGACACCATGACCAAGTGTGCCGAGCTG
CTGAGCCGCACCGTGGAGGTGGACTTTGTGGACATCAACGTCGGCTGCCCCATCGACCTC
GTGTACAAGAAGGGTGGGGGCTGTGCCCTCATGAATCGCTCCACCAAGTTCCAGCAGATC
GTCCGTGGCATGAACCAGGTGCTGGATGTGCCGCTGACTGTGAAGATCCGCACAGGCGTC
CAGGAGCGTGTGAACCTGGCGCACCGCCTGCTGCCCGAGCTGCGGGACTGGGGCGTGGCA
CTCGTCACGCTCCACGGCCGCTCTCGGGAGCAGCGCTACACCAAGCTAGCCGACTGGCAG
TACATCGAGGAGTGCGTGCAGGCCGCCAGCCCCATGCCCCTGTTCGGAAATGGGGACATC
TTGTCATTTGAGGATGCCAACCGCGCCATGCAGACTGGTGTCACCGGGATCATGATTGCC
CGTGGCGCCCTGCTCAAGCCGTGGCTCTTCACGGAGATCAAGGAGCAGCGGCACTGGGAC
ATCTCGTCGTCCGAGCGCCTGGACATCCTGCGGGACTTCACCAACTACGGCCTGGAGCAC
TGGGGCTCGGACACGCAGGGCGTGGAGAAGACCCGGCGCTTTCTGCTCGAGTGGCTGTCC
TTCCTGTGCCGGTACGTGCCCGTGGGGCTGCTGGAGCGGCTCCCACAGAGGATCAACGAG
CGGCCGCCCTACTACCTGGGCCGCGACTACCTGGAGACGCTGATGGCCAGCCAGAAGGCA
GCCGACTGGATCCGCATCAGCGAGATGCTCCTTGGGCCAGTGCCCCCCAGCTTCGCCTTC
TTGCCGAAGCACAAGGCCAACGCGTACAAGTAG
Protein Properties
Number of Residues 650
Molecular Weight 72593.3
Theoretical pI 8.11
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>tRNA-dihydrouridine synthase 3-like
MAEGTAEAPLENGGGGDSGAGALERGVAPIKRQYLTTKEQFHQFLEAKGQEKTCRETEVG
DPAGNELAEPEAKRIRLEDGQTADGQTEEAAEPGEQLQTQKRARGQNKGRPHVKPTNYDK
NRLCPSLIQESAAKCFFGDRCRFLHDVGRYLETKPADLGPRCVLFETFGRCPYGVTCRFA
GAHLRPEGQNLVQEELAARGTQPPSIRNGLDKALQQQLRKREVRFERAEQALRRFSQGPT
PAAAVPEGTAAEGAPRQENCGAQQVPAGPGTSTPPSSPVRTCGPLTDEDVVRLRPCEKKR
LDIRGKLYLAPLTTCGNLPFRRICKRFGADVTCGEMAVCTNLLQGQMSEWALLKRHQCED
IFGVQLEGAFPDTMTKCAELLSRTVEVDFVDINVGCPIDLVYKKGGGCALMNRSTKFQQI
VRGMNQVLDVPLTVKIRTGVQERVNLAHRLLPELRDWGVALVTLHGRSREQRYTKLADWQ
YIEECVQAASPMPLFGNGDILSFEDANRAMQTGVTGIMIARGALLKPWLFTEIKEQRHWD
ISSSERLDILRDFTNYGLEHWGSDTQGVEKTRRFLLEWLSFLCRYVPVGLLERLPQRINE
RPPYYLGRDYLETLMASQKAADWIRISEMLLGPVPPSFAFLPKHKANAYK
GenBank ID Protein 10436076
UniProtKB/Swiss-Prot ID Q96G46
UniProtKB/Swiss-Prot Entry Name DUS3L_HUMAN
PDB IDs Not Available
GenBank Gene ID AK023958
GeneCard ID DUS3L
GenAtlas ID DUS3L
HGNC ID HGNC:26920
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  4. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  5. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
  6. Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR 3rd: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. J Proteome Res. 2008 Mar;7(3):1346-51. doi: 10.1021/pr0705441. Epub 2008 Jan 26. [PubMed:18220336 ]