Hmdb loader
Identification
HMDB Protein ID HMDBP08272
Secondary Accession Numbers
  • 13984
Name FAD-dependent oxidoreductase domain-containing protein 2
Synonyms
  1. Endoplasmic reticulum flavoprotein associated with degradation
Gene Name FOXRED2
Protein Type Unknown
Biological Properties
General Function Inorganic ion transport and metabolism
Specific Function Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Endoplasmic reticulum lumen
Gene Properties
Chromosome Location Chromosome:2
Locus 22q12.3
SNPs FOXRED2
Gene Sequence
>2055 bp
ATGGGCCTCTCCGCTGCGGCCCCGTTGTGGGGTCCCCCGGGGCTGCTCCTGGCCATCGCC
CTGCACCCAGCGCTGTCGGTGCCCCCGCGCCGGGACTACTGCGTGCTGGGCGCTGGGCCC
GCGGGCCTGCAGATGGCCTACTTCCTGCAGCGCGCTGGACGCGACTACGCAGTGTTCGAG
CGGGCCCCGCGGCCCGGCAGCTTCTTCACACGCTACCCGCGGCACCGCAAGCTCATCAGC
ATCAACAAGCGGTACACGGGCAAGGCTAACGCCGAGTTCAACCTCCGCCACGACTGGAAC
TCTCTGCTCAGCCACGACCCCCGGCTGCTCTTCAGACACTACTCGCGTGCCTACTTCCCC
GACGCCCGCGACATGGTGCGCTACCTGGGTGACTTCGCGGACACGCTGGGGCTCCGTGTC
CAGTACAACACCACCATCGCCCACGTCACTCTGGACAAGGACCGACAGGCCTGGAATGGC
CACTACTTCATCCTAACTGACCAGAAGGGCCAGGTGCATCAGTGCAGCGTCCTCTTTGTA
GCCACTGGTTTATCAGTCCCCAACCAGGTCGACTTCCCTGGCTCCGAATATGCAGAGGGT
TACGAGTCCGTGTCCGTGGACCCTGAGGACTTTGTAGGCCAGAATGTGCTGATCCTGGGT
CGTGGGAACTCGGCCTTTGAGACAGCAGAGAACATCTTGGGTGTCACAAACTTTATCCAT
ATGCTCAGCCGCTCCCGGGTCCGTCTGTCCTGGGCCACCCACTACGTTGGAGACCTCAGA
GCCATCAACAATGGCCTGCTGGATACCTACCAGCTCAAGTCCCTGGACGGGCTGCTCGAG
TCTGACCTGACGGATCTGGCCATCCTGAAGGACAGCAAAGGCAAGTTCCATGTCACCCCG
AAATTCTTCCTGGAAGAAGCCAACACCAACCAGAGTGCCGACTCCATCACCCTCCCCCAG
GACGACAATGACAACTTTGCCATGCGCGTGCCCTATGACCGGGTAATCCGCTGCCTGGGC
TGGAACTTTGACTTCTCCATTTTCAATAAGTCCCTCAGACTTAACTCGGGAAATGCATTC
GGCAAGAAGTACCCGCTGATTCGAGCTAGCTACGAATCCAAAGGAAGCCGGGGTCTGTTT
ATCCTGGGTACTGCCAGCCACTCGGTGGACTACCGGAAATCTGCTGGGGGCTTCATCCAC
GGATTCCGATACACAGTGCGTGCTGTTCACCGGCTCCTGGAGCACCGCCACCACAGCGTC
ACCTGGCCCGCCACTGAGCTCCCCATCACACAGCTGACCAGCTCCATCGTGCGGCGCGTG
AATGAGGCTTCTGGGCTCTACCAGATGTTCGGTGTGCTGGCCGATGTCATCCTGTTGAAG
GAGAATTCCACGGCCTTTGAGTACCTGGAGGAGTTCCCCATACAGATGCTGGCCCAGCTG
GAGACACTCACAGGGAGGAAGGCAAAGCACGGGCTCTTCGTCATCAACATGGAATATGGC
AGAAATTTCTCTGGCCCCGACAAGGACGTCTTCTTTGATGACCGGTCTGTGGGGCACACA
GAAGATGCCTGGCAGTCTAACTTTCTTCATCCTGTCATCTACTACTATAGATACCTCCCC
ACCGAACAGGAGGTGAGGTTCCGCCCTGCACACTGGCCCCTGCCTCGGCCCACGGCCATC
CATCACATCGTGGAAGACTTCTTAACAGACTGGACTGCCCCGATCGGGCACATCCTACCT
CTGAGGCGCTTCCTGGAGAACTGTTTGGACACCGATTTGCGAAGCTTCTATGCAGAGTCC
TGCTTCCTGTTCGCCCTCGCGCGCCAGAAGTTGCCACCCTTTTGCCAGCAGGGGTACCTG
AGGATGCAGGGACTCGTGAGTACCGAGAGCCTTTGGCAGCACAGAGTGGAGAGCAGGCTC
CTGCGGGACTATGCCCCCACAGGCAGGCGCCTGGAGGACAGCAGCCAGCAGCTTGGCGAC
CAAGAGCCACTAGGTTCCCCCCTGGCTCCAGGGCCTCTGGCTCAGTCCGTCGATAGCAAC
AAAGAGGAGCTCTGA
Protein Properties
Number of Residues 684
Molecular Weight 77790.4
Theoretical pI 7.78
Pfam Domain Function
Signals
  • 1-26
Transmembrane Regions
  • None
Protein Sequence
>FAD-dependent oxidoreductase domain-containing protein 2
MGLSAAAPLWGPPGLLLAIALHPALSVPPRRDYCVLGAGPAGLQMAYFLQRAGRDYAVFE
RAPRPGSFFTRYPRHRKLISINKRYTGKANAEFNLRHDWNSLLSHDPRLLFRHYSRAYFP
DARDMVRYLGDFADTLGLRVQYNTTIAHVTLDKDRQAWNGHYFILTDQKGQVHQCSVLFV
ATGLSVPNQVDFPGSEYAEGYESVSVDPEDFVGQNVLILGRGNSAFETAENILGVTNFIH
MLSRSRVRLSWATHYVGDLRAINNGLLDTYQLKSLDGLLESDLTDLAILKDSKGKFHVTP
KFFLEEANTNQSADSITLPQDDNDNFAMRVPYDRVIRCLGWNFDFSIFNKSLRLNSGNAF
GKKYPLIRASYESKGSRGLFILGTASHSVDYRKSAGGFIHGFRYTVRAVHRLLEHRHHSV
TWPATELPITQLTSSIVRRVNEASGLYQMFGVLADVILLKENSTAFEYLEEFPIQMLAQL
ETLTGRKAKHGLFVINMEYGRNFSGPDKDVFFDDRSVGHTEDAWQSNFLHPVIYYYRYLP
TEQEVRFRPAHWPLPRPTAIHHIVEDFLTDWTAPIGHILPLRRFLENCLDTDLRSFYAES
CFLFALTRQKLPPFCQQGYLRMQGLVSTESLWQHRVESRLLRDYAPTGRRLEDSSQQLGD
QEPLGSPLAPGPLAQSVDSNKEEL
GenBank ID Protein 10438323
UniProtKB/Swiss-Prot ID Q8IWF2
UniProtKB/Swiss-Prot Entry Name FXRD2_HUMAN
PDB IDs Not Available
GenBank Gene ID AK025714
GeneCard ID FOXRED2
GenAtlas ID FOXRED2
HGNC ID HGNC:26264
References
General References
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  4. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al.: The DNA sequence of human chromosome 22. Nature. 1999 Dec 2;402(6761):489-95. [PubMed:10591208 ]
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