Hmdb loader
Identification
HMDB Protein ID HMDBP08288
Secondary Accession Numbers
  • 14000
Name Sulfhydryl oxidase 2
Synonyms
  1. Neuroblastoma-derived sulfhydryl oxidase
  2. Quiescin Q6-like protein 1
Gene Name QSOX2
Protein Type Unknown
Biological Properties
General Function Involved in thiol oxidase activity
Specific Function Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis.
Pathways Not Available
Reactions
R'C(R)SH + Oxygen → R'C(R)S-S(R)CR' + Hydrogen peroxide details
GO Classification
Biological Process
cell redox homeostasis
Cellular Component
plasma membrane
extracellular region
nuclear membrane
integral to membrane
Function
catalytic activity
oxidoreductase activity, acting on a sulfur group of donors
oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor
thiol oxidase activity
oxidoreductase activity
Molecular Function
thiol oxidase activity
Process
metabolic process
cellular process
oxidation reduction
cellular homeostasis
cell redox homeostasis
Cellular Location
  1. Cell membrane
  2. Secreted
  3. Membrane
  4. Single-pass membrane protein
  5. Single-pass membrane protein (Potential)
  6. Single-pass membrane protein (Potential)
  7. Nucleus membrane
Gene Properties
Chromosome Location 9
Locus 9q34.3
SNPs QSOX2
Gene Sequence
>2097 bp
ATGGCGGCGGCCGGGGCGGCGGTAGCGCGCAGCCCGGGAATCGGAGCGGGACCTGCGCTG
AGAGCCCGGCGCTCGCCCCCGCCGCGGGCCGCACGGCTGCCGCGGCTGCTAGTGCTGCTA
GCGGCGGCGGCGGTGGGGCCGGGCGCGGGCGGTGCGGCGCGGCTGTACCGCGCGGGCGAG
GACGCCGTGTGGGTGCTGGACAGCGGCAGCGTGCGCGGGGCCACCGCCAACAGCTCGGCC
GCGTGGCTCGTGCAGTTCTACTCGTCGTGGTGTGGCCACTGCATCGCGTACGCGCCCACT
TGGCGGGCCCTGGCTGGGGATGTGCGAGACTGGGCCAGTGCCATTCGCGTCGCAGCTCTG
GACTGCATGGAAGAGAAGAACCAGGCCGTGTGCCATGACTACGACATCCACTTCTACCCC
ACCTTCCGGTATTTTAAAGCATTTACAAAGGAGTTTACAACTGGAGAAAATTTTAAAGGA
CCTGACCGAGAGCTGCGAACAGTCAGACAGACGATGATTGACTTCCTGCAGAACCACACG
GAAGGAAGCCGGCCCCCTGCCTGCCCGCGCCTAGACCCCATTCAGCCCAGTGATGTTCTT
TCCCTTCTTGACAACCGTGGCAGCCATTACGTGGCTATCGTCTTTGAAAGCAACAGCTCC
TACCTTGGATGGGAGGTGATCTTAGACCTGATCCCGTATGAAAGCATCGTGGTGACCCGA
GCACTGGACGGGGACAAAGCATTTCTGGAGAAACTTGGTGTTTCTTCAGTCCCTTCGTGT
TACCTGATCTACCCAAATGGGTCGCATGGATTGATTAACGTCGTGAAGCCTCTGCGGGCC
TTCTTTTCGTCTTATTTGAAGTCATTGCCGGATGTGAGGAAAAAATCGCTTCCCTTGCCT
GAAAAGCCACACAAAGAAGAAAATTCAGAAATCGTGGTTTGGAGAGAATTTGACAAGTCG
AAGCTGTACACGGTGGACCTGGAGTCAGGGCTACACTACCTCCTGCGGGTGGAGCTGGCA
GCCCACAAGTCCCTGGCCGGAGCAGAGCTGAAGACGCTNCAAGGACTTTGTGACTGTCTT
GGCCAAGCTGTTCCCTGGACGGCCGCCGTCAAGAAGCTGTTGGAGATGCTGCAGGAGTGG
CTGGCCAGCCTTCCCCTGGACAGGATCCCCTACAACGCCGTGCTTGACCTGGTCAACAAC
AAGATGCGGATTTCTGGAATATTCCTTACTAATCACATAAAGTGGGTTGGATGTCAAGGA
AGCCGATCTGAGTTGAGGGGTTACCCGTGTTCTCTCTGGAAACTGTTCCACACTTTGACT
GTTGAAGCCTCGACCCACCCAGATGCACTGGTTGGCACAGGCTTTGAAGACGACCCCCAG
GCTGTGCTGCAGACAATGAGGAGGTACGTTCACACCTTCTTTGGGTGTAAGGAATGTGGT
GAGCACTTTGAGGAAATGGCTAAAGAATCCATGGACTCGGTGAAAACCCCAGACCAAGCC
ATCCTCTGGCTGTGGAAGAAGCATAATATGGTGAACGGCCGCCTGGCAGGCCATCTGAGT
GAGGATCCCCGGTTTCCAAAGCTTCAGTGGCCCACTCCGGACCTCTGCCCAGCCTGCCAT
GAGGAAATTAAGGGCCTGGCCAGCTGGGATGAAGGCCACGTGCTCACATTCTTGAAGCAG
CACTATGGCCGCGACAACCTCTTAGACACGTATTCCGCAGACCAGGGGGATTCCAGTGAA
GGAGGAACCCTGGCCAGGGGTGAGGAAGAGGAGAAAAGACTCACTCCCCCAGAGGTGTCC
CATGGAGACCGAGACACCCAGAGCGTCCGTCCACCTGGTGCACTGGCCCCAGGGCCTGCC
CTTCCAGAGAGCTTGCATCACAGCTTGGACGGGAAACTCCAGAGTCTGGATGGGCCCGGG
GCCCACAAGGAGGTGGGCGGGGCCGCACCCTTCCTCGGGGTTGACTTCTCCAGCCTGGAC
ATGAGTCTCTGTGTCGTGCTGTACGTGGCTTCATCCCTGTTCCTCATGGTGATGTACTTC
TTCTTCCGGGTGAGGTCCAGGCGGTGGAAGGTCAAGCACCACCACCCGGCCGTGTGA
Protein Properties
Number of Residues 698
Molecular Weight 77527.975
Theoretical pI 7.723
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Sulfhydryl oxidase 2
MAAAGAAVARSPGIGAGPALRARRSPPPRAARLPRLLVLLAAAAVGPGAGGAARLYRAGE
DAVWVLDSGSVRGATANSSAAWLVQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAAL
DCMEEKNQAVCHDYDIHFYPTFRYFKAFTKEFTTGENFKGPDRELRTVRQTMIDFLQNHT
EGSRPPACPRLDPIQPSDVLSLLDNRGSHYVAIVFESNSSYLGREVILDLIPYESIVVTR
ALDGDKAFLEKLGVSSVPSCYLIYPNGSHGLINVVKPLRAFFSSYLKSLPDVRKKSLPLP
EKPHKEENSEIVVWREFDKSKLYTVDLESGLHYLLRVELAAHKSLAGAELKTLKDFVTVL
AKLFPGRPPVKKLLEMLQEWLASLPLDRIPYNAVLDLVNNKMRISGIFLTNHIKWVGCQG
SRSELRGYPCSLWKLFHTLTVEASTHPDALVGTGFEDDPQAVLQTMRRYVHTFFGCKECG
EHFEEMAKESMDSVKTPDQAILWLWKKHNMVNGRLAGHLSEDPRFPKLQWPTPDLCPACH
EEIKGLASWDEGHVLTFLKQHYGRDNLLDTYSADQGDSSEGGTLARGEEEEKRLTPPEVS
HGDRDTQSVRPPGALGPRPALPESLHHSLDGKLQSLDGPGAHKEVGGAAPFLGVDFSSLD
MSLCVVLYVASSLFLMVMYFFFRVRSRRWKVKHHHPAV
GenBank ID Protein 30842594
UniProtKB/Swiss-Prot ID Q6ZRP7
UniProtKB/Swiss-Prot Entry Name QSOX2_HUMAN
PDB IDs Not Available
GenBank Gene ID AJ318051
GeneCard ID QSOX2
GenAtlas ID QSOX2
HGNC ID HGNC:30249
References
General References
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