Hmdb loader
Identification
HMDB Protein ID HMDBP08289
Secondary Accession Numbers
  • 14001
Name Renalase
Synonyms
  1. MAO-C
  2. Monoamine oxidase-C
Gene Name RNLS
Protein Type Unknown
Biological Properties
General Function Involved in oxidoreductase activity
Specific Function Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Secreted
Gene Properties
Chromosome Location Chromosome:1
Locus 10q23.31
SNPs RNLS
Gene Sequence
>1029 bp
ATGGCGCAGGTGCTGATCGTGGGCGCCGGGATGACAGGAAGCTTGTGCGCTGCGCTGCTG
AGGAGGCAGACGTCCGGTCCCTTGTACCTTGCTGTGTGGGACAAGGCTGAGGACTCAGGG
GGAAGAATGACTACAGCCTGCAGTCCTCATAATCCTCAGTGCACAGCTGACTTGGGTGCT
CAGTACATCACCTGCACTCCTCATTATGCCAAAAAACACCAACGTTTTTATGATGAACTG
TTAGCCTATGGCGTTTTGAGGCCTCTAAGCTCGCCTATTGAAGGAATGGTGATGAAAGAA
GGAGACTGTAACTTTGTGGCACCTCAAGGAATTTCTTCAATTATTAAGCATTACTTGAAA
GAATCAGGTGCAGAAGTCTACTTCAGACATCGTGTGACACAGATCAACCTAAGAGATGAC
AAATGGGAAGTATCCAAACAAACAGGCTCCCCTGAGCAGTTTGATCTTATTGTTCTCACA
ATGCCAGTTCCTGAGATTCTGCAGCTTCAAGGTGACATCACCACCTTAATTAGTGAATGC
CAAAGGCAGCAACTGGAGGCTGTGAGCTACTCCTCTCGATATGCTCTGGGCCTCTTTTAT
GAAGCTGGTACGAAGATTGATGTCCCTTGGGCTGGGCAGTACATCACCAGTAATCCCTGC
ATACGCTTCGTCTCCATTGATAATAAGAAGCGCAATATAGAGTCATCAGAAATTGGGCCT
TCCCTCGTGATTCACACCACTGTCCCATTTGGAGTTACATACTTGGAACACAGCATTGAG
GATGTGCAAGAGTTAGTCTTCCAGCAGCTGGAAAACATTTTGCCGGGTTTGCCTCAGCCA
ATTGCTACCAAATGCCAAAAATGGAGACATTCACAGGTTACAAATGCTGCTGCCAACTGT
CCTGGCCAAATGACTCTGCATCACAAACCTTTCCTTGCATGTGGAGGGGATGGATTTACT
CAGTCCAACTTTGATGGCTGCATCACTTCTGCCCTATGTGTTCTGGAAGCTTTAAAGAAT
TATATTTAG
Protein Properties
Number of Residues 342
Molecular Weight 37847.0
Theoretical pI 6.5
Pfam Domain Function
Signals
  • 1-17
Transmembrane Regions
  • None
Protein Sequence
>Renalase
MAQVLIVGAGMTGSLCAALLRRQTSGPLYLAVWDKAEDSGGRMTTACSPHNPQCTADLGA
QYITCTPHYAKKHQRFYDELLAYGVLRPLSSPIEGMVMKEGDCNFVAPQGISSIIKHYLK
ESGAEVYFRHRVTQINLRDDKWEVSKQTGSPEQFDLIVLTMPVPEILQLQGDITTLISEC
QRQQLEAVSYSSRYALGLFYEAGTKIDVPWAGQYITSNPCIRFVSIDNKKRNIESSEIGP
SLVIHTTVPFGVTYLEHSIEDVQELVFQQLENILPGLPQPIATKCQKWRHSQVTNAAANC
PGQMTLHHKPFLACGGDGFTQSNFDGCITSALCVLEALKNYI
GenBank ID Protein 237649117
UniProtKB/Swiss-Prot ID Q5VYX0
UniProtKB/Swiss-Prot Entry Name RNLS_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001031709.2
GeneCard ID RNLS
GenAtlas ID RNLS
HGNC ID HGNC:25641
References
General References
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  4. Xu J, Li G, Wang P, Velazquez H, Yao X, Li Y, Wu Y, Peixoto A, Crowley S, Desir GV: Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure. J Clin Invest. 2005 May;115(5):1275-80. Epub 2005 Apr 7. [PubMed:15841207 ]
  5. Boomsma F, Tipton KF: Renalase, a catecholamine-metabolising enzyme? J Neural Transm (Vienna). 2007;114(6):775-6. Epub 2007 Mar 26. [PubMed:17385068 ]