Hmdb loader
Identification
HMDB Protein ID HMDBP08317
Secondary Accession Numbers
  • 14029
Name Brefeldin A-inhibited guanine nucleotide-exchange protein 1
Synonyms
  1. Brefeldin A-inhibited GEP 1
  2. p200 ARF guanine nucleotide exchange factor
  3. p200 ARF-GEP1
Gene Name ARFGEF1
Protein Type Unknown
Biological Properties
General Function Involved in binding
Specific Function Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular
Function
small gtpase regulator activity
binding
enzyme regulator activity
arf guanyl-nucleotide exchange factor activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
Process
regulation of ras protein signal transduction
biological regulation
regulation of biological process
regulation of arf protein signal transduction
regulation of cellular process
regulation of cell communication
regulation of signal transduction
regulation of small gtpase mediated signal transduction
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:8
Locus 8q13
SNPs ARFGEF1
Gene Sequence
>5550 bp
ATGTATGAGGGGAAGAAGACGAAGAACATGTTCCTGACCCGGGCTCTGGAGAAGATATTG
GCCGACAAGGAAGTGAAGAAGGCGCATCACTCCCAGCTGCGCAAAGCTTGCGAGGTGGCG
TTAGAGGAAATAAAAGCGGAAACTGAAAAACAGAGTCCTCCTCATGGAGAAGCAAAAGCT
GGATCAAGCACCCTTCCACCAGTGAAATCAAAGACAAATTTTATTGAAGCAGACAAGTAC
TTCTTGCCTTTTGAGTTGGCATGCCAGTCCAAATGTCCTCGCATAGTTAGTACATCTCTA
GATTGCTTACAGAAACTTATTGCTTATGGGCACTTGACTGGCAATGCTCCAGATAGTACA
ACACCAGGCAAAAAATTAATTGATAGAATTATTGAAACAATATGTGGCTGCTTTCAGGGC
CCTCAGACAGATGAAGGAGTTCAGCTGCAGATAATAAAGGCTTTACTTACTGCAGTAACA
TCACAACACATAGAAATTCATGAAGGGACTGTACTGCAAGCTGTGAGAACATGTTACAAT
ATCTACTTAGCAAGCAAAAATCTCATCAATCAGACAACAGCCAAAGCTACTCTCACTCAG
ATGCTAAATGTTATCTTTGCACGCATGGAAAACCAAGCATTACAGGAAGCAAAACAAATG
GAAAAAGAAAGGCATCGGCAGCATCATCATCTGTTACCGTCTCCAGTAAGCCATCACGAG
CCTGAATCACCTCAACTTAGATATTTGCCACCTCAGACTGTTGATCATATATCCCAAGAA
CACGAAGGGGACCTTGACCTCCATACAAATGATGTAGATAAAAGTCTTCAGGATGACACA
GAGCCTGAAAATGGATCTGATATTTCCAGTGCAGAAAATGAACAGACTGAAGCTGATCAG
GCAACTGCAGCTGAAACATTATCTAAAAATGAAGTGTTATATGACGGAGAAAACCATGAT
TGTGAGGAAAAGCCACAAGACATTGTACAGAACATTGTAGAAGAAATGGTGAACATTGTT
GTTGGAGATATGGGAGAAGGGACTACTATAAATGCAAGTGCAGATGGCAACATTGGAACT
ATAGAGGATGGTAGTGACAGTGAAAATATTCAAGCAAATGGAATTCCAGGAACACCAATT
TCTGTTGCATATACACCATCCTTACCTGATGATAGATTGTCAGTCTCTTCCAATGATACT
CAGGAATCTGGAAATTCTTCAGGACCTTCACCTGGTGCTAAGTTTTCCCACATTTTACAA
AAGGATGCCTTTCTAGTATTCAGGTCATTGTGTAAACTGTCAATGAAACCACTGTCAGAT
GGACCACCAGATCCAAAGTCTCATGAACTACGATCCAAGATTCTTTCATTGCAGTTACTT
CTATCCATTCTGCAGAATGCAGGACCTATTTTCAGGACAAATGAGATGTTTATTAATGCT
ATTAAGCAGTATCTTTGTGTTGCACTCTCAAAAAATGGAGTCTCATCTGTTCCAGAGGTT
TTTGAGCTTTCTCTTTCTATATTTCTTACTTTGTTGTCAAATTTCAAGACACATCTGAAG
ATGCAAATTGAGGTGTTCTTTAAAGAAATTTTCTTATACATTTTGGAAACTTCTACCAGC
TCATTTGATCACAAATGGATGGTTATTCAGACACTGACGAGGATTTGTGCAGATGCTCAG
AGTGTAGTGGATATTTATGTAAACTATGACTGTGACTTAAATGCAGCCAATATATTTGAA
AGACTAGTAAATGATCTATCAAAAATTGCTCAAGGAAGGGGCAGTCAAGAACTTGGTATG
AGTAATGTTCAGGAATTGAGCCTGAGGAAAAAAGGTTTAGAATGCTTAGTGTCGATTTCG
AAGTGTATGGTTGAATGGAGTAAGGATCAGTATGTGAATCCCAACTCCCAGACAACTCTT
GGTCAGGAAAAACCCTCAGAGCAAGAGATGAGTGAAATCAAACACCCTGAGACAATAAAC
AGATACGGAAGTTTAAATTCCCTGGAGTCAACATCATCATCAGGAATAGGCAGCTACAGT
ACACAGATGTCTGGCACTGATAATCCAGAACAATTTGAGGTCCTAAAGCAACAAAAAGAA
ATAATAGAACAAGGGATAGATTTATTTAATAAGAAACCAAAGAGAGGAATACAGTACCTC
CAAGAACAAGGGATGCTTGGCACCACACCTGAAGATATTGCCCAATTCTTACATCAAGAG
GAAAGATTAGACTCTACTCAAGTGGGTGAGTTCCTGGGAGATAATGATAAATTTAACAAA
GAAGTCATGTATGCATATGTGGACCAACATGACTTTTCAGGAAAAGACTTCGTTTCAGCC
CTTCGTATGTTTCTAGAAGGATTTCGTCTTCCAGGGGAAGCTCAGAAAATCGATCGATTA
ATGGAAAAATTTGCTGCAAGATACCTAGAATGCAACCAAGGACAAACTCTCTTTGCTAGT
GCGGATACAGCTTATGTTTTGGCTTATTCAATTATCATGTTGACCACAGACCTTCACAGT
CCACAGGTGAAAAATAAAATGACAAAGGAACAATACATTAAGATGAATAGAGGTATCAAT
GACAGTAAAGACCTTCCTGAAGAGTATCTATCAGCCATCTATAATGAAATAGCTGGGAAA
AAGATATCAATGAAAGAAACAAAAGAACTAACAATCCCTACAAAATCAAGTAAACAGAAT
GTAGCCAGTGAAAAACAAAGAAGACTTCTGTATAACTTAGAAATGGAGCAGATGGCCAAG
ACAGCTAAAGCACTCATGGAGGCCGTGAGCCATGTTCAGGCACCCTTTACAAGTGCAACA
CATTTGGAGCATGTGAGGCCCATGTTTAAGTTGGCTTGGACGCCTTTTCTGGCTGCATTC
AGTGTGGGTCTACAAGATTGTGATGATACTGAAGTAGCCTCTCTTTGCCTGGAAGGTATA
AGATGTGCAATCAGAATTGCATGCATTTTCAGCATTCAGCTGGAGAGAGATGCATATGTC
CAGGCACTAGCAAGATTTACCTTACTCACAGTGAGTTCCGGTATTACTGAAATGAAACAG
AAGAACATTGACACAATAAAAACACTTATCACAGTGGCTCATACAGATGGAAATTATTTA
GGAAATTCATGGCATGAGATTCTGAAGTGCATCAGTCAGTTGAAGCTGGCACAGCTTATA
GGAACTGGAGTGAAACCTCGATACATTTCTGGAACAGTGCGAGGCAGAGAAGGATCTCTT
ACTGGAACAAAAGATCAGGCTCCTGATGAATTTGTGGGTTTAGGGCTAGTTGGAGGAAAT
GTGGACTGGAAACAGATAGCAAGTATTCAGGAATCCATTGGAGAAACCAGTTCTCAGAGT
GTTGTTGTTGCTGTAGATAGAATATTCACAGGATCTACAAGGCTAGATGGAAATGCCATT
GTGGATTTTGTCCGTTGGCTCTGTGCTGTGTCTATGGATGAATTACTTTCCACGACACAC
CCAAGAATGTTTAGTCTACAAAAAATAGTAGAAATATCATATTACAACATGGGAAGAATA
AGATTACAGTGGTCTCGAATTTGGGAAGTTATTGGAGATCATTTTAATAAGGTTGGGTGT
AATCCTAATGAAGATGTAGCTATTTTTGCAGTAGACTCCTTGAGGCAGTTGTCAATGAAG
TTCTTAGAGAAAGGGGAGCTTGCTAACTTCAGATTCCAGAAGGATTTCTTAAGACCTTTT
GAACATATAATGAAACGGAACAGGTCTCCAACAATTCGAGATATGGTTGTACGGTGTATA
GCACAGATGGTTAATTCTCAAGCTGCTAACATTCGATCTGGATGGAAGAACATTTTCTCT
GTATTTCATCTAGCTGCATCTGATCAAGATGAAAGCATAGTGGAACTTGCATTCCAAACA
ACCGGGCACATTGTCACCCTTGTATTTGAAAAACACTTTCCAGCGACCATTGATTCTTTC
CAGGATGCAGTGAAGTGTTTGTCTGAATTTGCGTGCAATGCAGCTTTCCCAGACACAAGT
ATGGAAGCAATTCGACTTATTCGCCATTGTGCAAAATATGTGTCTGATAGACCTCAGGCT
TTCAAGGAATACACAAGCGATGATATGAACGTAGCACCTGAAGACAGGGTGTGGGTGAGA
GGATGGTTCCCAATTCTCTTTGAGTTATCCTGTATCATCAATAGATGCAAATTAGATGTA
AGAACCAGGGGTTTAACAGTAATGTTTGAAATAATGAAAACATATGGCCACACTTATGAG
AAACACTGGTGGCAGGATTTATTTAGAATTGTTTTCAGAATCTTTGACAATATGAAATTG
CCAGAACAACAGACAGAGAAAGCTGAATGGATGACAACAACTTGCAATCATGCACTTTAT
GCAATCTGTGATGTATTCACTCAGTATTTAGAAGTACTCAGTGATGTACTTTTGGATGAC
ATTTTTGCTCAGCTCTACTGGTGTGTGCAGCAAGACAATGAGCAGTTAGCGCGATCTGGT
ACAAACTGTTTAGAGAATGTTGTTATTCTGAATGGTGAAAAATTTACCCTAGAAATCTGG
GATAAAACTTGCAACTGCACACTGGATATCTTCAAAACCACAATCCCACATGCGCTGTTG
ACCTGGCGACCCAATTCTGGAGAAACTGCCCCCCCACCTCCATCTCCTGTAAGTGAAAAG
CCATTGGATACAATATCACAGAAGTCTGTAGATATTCATGATTCTATTCAACCAAGGTCT
GTGGATAACAGACCACAAGCACCACTGGTTTCTGCGTCTGCTGTTAATGAAGAAGTCAGC
AAAATTAAATCTACAGCAAAATTTCCAGAACAAAAATTGTTTGCTGCCCTGTTGATTAAA
TGTGTTGTGCAGCTGGAACTCATCCAGACTATCGACAACATTGTCTTCTTCCCAGCCACA
AGTAAGAAAGAAGATGCAGAAAACTTAGCTGCAGCACAGAGAGATGCGGTGGACTTTGAT
GTTCGCGTTGATACTCAAGACCAAGGAATGTACCGCTTTTTAACATCACAACAACTTTTT
AAGCTACTGGACTGCTTATTAGAGTCACATAGATTTGCAAAAGCGTTTAATTCCAACAAC
GAACAGAGGACTGCCCTGTGGAAAGCAGGATTCAAAGGCAAATCCAAGCCCAACCTTCTG
AAGCAGGAGACCAGCAGCCTGGCCTGTGGGCTGCGCATTCTCTTCCGGATGTACATGGAT
GAGAGCCGCGTTAGTGCCTGGGAGGAGGTCCAGCAGAGGCTTTTGAATGTCTGCAGTGAA
GCACTAAGTTACTTCCTCACTCTAACATCAGAAAGTCATCGAGAAGCCTGGACTAACTTA
CTGCTTTTGTTTCTAACTAAAGTTCTAAAGATAAGTGATAATAGGTTTAAAGCTCATGCA
TCATTCTACTACCCTCTCTTATGTGAAATTATGCAATTTGACTTGATTCCTGAACTTCGT
GCTGTTCTTAGAAGATTTTTTCTGCGAATCGGAGTAGTTTTTCAGATATCACAACCACCT
GAACAGGAACTTGGTATTAACAAACAGTGA
Protein Properties
Number of Residues 1849
Molecular Weight 208765.2
Theoretical pI 5.65
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Brefeldin A-inhibited guanine nucleotide-exchange protein 1
MYEGKKTKNMFLTRALEKILADKEVKKAHHSQLRKACEVALEEIKAETEKQSPPHGEAKA
GSSTLPPVKSKTNFIEADKYFLPFELACQSKCPRIVSTSLDCLQKLIAYGHLTGNAPDST
TPGKKLIDRIIETICGCFQGPQTDEGVQLQIIKALLTAVTSQHIEIHEGTVLQAVRTCYN
IYLASKNLINQTTAKATLTQMLNVIFARMENQALQEAKQMEKERHRQHHHLLQSPVSHHE
PESPQLRYLPPQTVDHISQEHEGDLDLHTNDVDKSLQDDTEPENGSDISSAENEQTEADQ
ATAAETLSKNEVLYDGENHDCEEKPQDIVQNIVEEMVNIVVGDMGEGTTINASADGNIGT
IEDGSDSENIQANGIPGTPISVAYTPSLPDDRLSVSSNDTQESGNSSGPSPGAKFSHILQ
KDAFLVFRSLCKLSMKPLSDGPPDPKSHELRSKILSLQLLLSILQNAGPIFRTNEMFINA
IKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETSTS
SFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGM
SNVQELSLRKKGLECLVSILKCMVEWSKDQYVNPNSQTTLGQEKPSEQEMSEIKHPETIN
RYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYL
QEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSA
LRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHS
PQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPTKSSKQN
VASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKLAWTPFLAAF
SVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGITEMKQ
KNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKPRYISGTVRGREGSL
TGTKDQAPDEFVGLGLVGGNVDWKQIASIQESIGETSSQSVVVAVDRIFTGSTRLDGNAI
VDFVRWLCAVSMDELLSTTHPRMFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFNKVGC
NPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKRNRSPTIRDMVVRCI
AQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGHIVTLVFEKHFPATIDSF
QDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMNVAPEDRVWVR
GWFPILFELSCIINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRIVFRIFDNMKL
PEQQTEKAEWMTTTCNHALYAICDVFTQYLEVLSDVLLDDIFAQLYWCVQQDNEQLARSG
TNCLENVVILNGEKFTLEIWDKTCNCTLDIFKTTIPHALLTWRPNSGETAPPPPSPVSEK
PLDTISQKSVDIHDSIQPRSVDNRPQAPLVSASAVNEEVSKIKSTAKFPEQKLFAALLIK
CVVQLELIQTIDNIVFFPATSKKEDAENLAAAQRDAVDFDVRVDTQDQGMYRFLTSQQLF
KLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSKPNLLKQETSSLACGLRILFRMYMD
ESRVSAWEEVQQRLLNVCSEALSYFLTLTSESHREAWTNLLLLFLTKVLKISDNRFKAHA
SFYYPLLCEIMQFDLIPELRAVLRRFFLRIGVVFQISQPPEQELGINKQ
GenBank ID Protein 5052121
UniProtKB/Swiss-Prot ID Q9Y6D6
UniProtKB/Swiss-Prot Entry Name BIG1_HUMAN
PDB IDs Not Available
GenBank Gene ID AF084520
GeneCard ID ARFGEF1
GenAtlas ID ARFGEF1
HGNC ID HGNC:15772
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [PubMed:19608861 ]
  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  4. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [PubMed:18691976 ]
  5. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [PubMed:17081983 ]
  6. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
  7. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  8. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [PubMed:16959974 ]
  9. Togawa A, Morinaga N, Ogasawara M, Moss J, Vaughan M: Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors. J Biol Chem. 1999 Apr 30;274(18):12308-15. [PubMed:10212200 ]
  10. Mansour SJ, Skaug J, Zhao XH, Giordano J, Scherer SW, Melancon P: p200 ARF-GEP1: a Golgi-localized guanine nucleotide exchange protein whose Sec7 domain is targeted by the drug brefeldin A. Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7968-73. [PubMed:10393931 ]
  11. Padilla PI, Chang MJ, Pacheco-Rodriguez G, Adamik R, Moss J, Vaughan M: Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2322-7. Epub 2003 Feb 26. [PubMed:12606707 ]
  12. Xu Z, Gong Q, Xia B, Groves B, Zimmermann M, Mugler C, Mu D, Matsumoto B, Seaman M, Ma D: A role of histone H3 lysine 4 methyltransferase components in endosomal trafficking. J Cell Biol. 2009 Aug 10;186(3):343-53. doi: 10.1083/jcb.200902146. Epub 2009 Aug 3. [PubMed:19651892 ]