Hmdb loader
Identification
HMDB Protein ID HMDBP08346
Secondary Accession Numbers
  • 14058
Name Protein diaphanous homolog 3
Synonyms
  1. DRF3
  2. Diaphanous-related formin-3
Gene Name DIAPH3
Protein Type Unknown
Biological Properties
General Function Involved in actin binding
Specific Function Binds to GTP-bound form of Rho and to profilin. Acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. It is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
protein binding
cytoskeletal protein binding
actin binding
gtpase binding
small gtpase binding
ras gtpase binding
rho gtpase binding
enzyme binding
Process
cytoskeleton organization
actin cytoskeleton organization
cellular process
cellular component organization at cellular level
organelle organization
cellular component organization or biogenesis
cellular component organization
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:1
Locus 13q21.2
SNPs DIAPH3
Gene Sequence
>3582 bp
ATGGAACGGCACCAGCCGCGGCTGCACCACCCGGCCCAAGGCTCAGCCGCTGGGACTCCC
TACCCTTCCTCAGCCTCTCTCCGCGGCTGCCGGGAAAGCAAGATGCCGCGCAGGAAGGGC
CCCCAACACCCTCCGCCGCCCAGTGGCCCCGAGGAGCCTGGGGAGAAGCGCCCCAAGTTT
CATTTAAATATTAGGACACTGACGGATGATATGCTGGACAAATTTGCCAGCATAAGAATT
CCAGGGAGCAAGAAAGAGAGACCTCCACTTCCCAACCTGAAGACTGCATTTGCAAGCAGT
GATTGCTCAGCAGCACCTTTAGAGATGATGGAGAACTTTCCAAAGCCACTGTCAGAGAAT
GAACTCTTAGAACTTTTTGAAAAAATGATGGAAGATATGAATTTAAATGAAGATAAAAAG
GCACCATTGCGGGAAAAGGACTTCAGTATCAAAAAAGAAATGGTGATGCAGTACATTAAT
ACTGCTTCTAAGACAGGAAGTCTTAAGAGAAGCCGACAGATCTCACCTCAGGAATTCATT
CATGAGCTGAAAATGGGGTCTGCAGATGAGAGACTTGTCACATGCCTGGAGTCTCTCCGA
GTGTCTTTGACCAGCAATCCTGTGAGTTGGGTGGAAAGCTTTGGACATGAAGGGCTTGGA
TTATTATTAGACATTTTGGAAAAACTGATTAGTGGAAAAATCCAAGAAAAAGTTGTAAAG
AAAAATCAACATAAAGTCATACAGTGTCTAAAAGCCCTGATGAATACGCAGTATGGCTTG
GAAAGAATTATGAGTGAGGAGAGGAGCCTTTCCTTATTGGCCAAAGCCGTGGATCCCAGA
CACCCCAATATGATGACAGATGTGGTTAAACTTCTCTCTGCGGTATGCATTGTAGGGGAA
GAAAGCATCCTTGAAGAAGTTTTAGAAGCTTTAACTTCAGCTGGTGAAGAAAAAAAAATT
GACAGATTTTTTTGTATTGTGGAAGGCCTCCGGCACAATTCAGTTCAACTGCAAGTAGCT
TGTATGCAGCTCATCAATGCCCTGGTTACATCTCCTGATGATTTGGATTTCAGGCTTCAC
ATCAGAAATGAATTTATGCGTTGTGGATTGAAAGAGATATTGCCAAATTTAAAATGCATT
AAGAATGATGGCCTGGATATCCAACTTAAAGTCTTTGATGAGCATAAAGAAGAAGATTTG
TTTGAGTTATCCCATCGCCTTGAAGATATTAGAGCTGAACTTGATGAAGCATATGATGTT
TACAACATGGTGTGGAGCACAGTTAAAGAAACTAGAGCAGAGGGATATTTTATTTCTATT
CTTCAGCATCTTTTGCTGATTCGAAATGATTATTTTATAAGGCAACAATACTTCAAATTA
ATTGATGAGTGTGTATCCCAGATTGTATTGCATAGAGATGGAATGGATCCAGACTTCACA
TATCGAAAAAGACTAGATTTAGATTTAACCCAGTTTGTAGACATTTGCATAGATCAAGCA
AAACTAGAAGAGTTTGAAGAGAAAGCATCAGAACTTTACAAGAAATTTGAAAAAGAGTTT
ACCGACCACCAAGAAACTCAGGCTGAATTGCAGAAAAAAGAGGCAAAGATTAATGAGCTT
CAAGCAGAGCTACAAGCTTTTAAGTCTCAGTTTGGTGCCTTGCCAGCTGATTGTAATATT
CCTTTGCCTCCCTCTAAAGAAGGTGGAACTGGCCACTCAGCACTTCCTCCTCCGCCTCCA
CTGCCTTCTGGTGGAGGGGTGCCGCCTCCACCTCCTCCCCCACCACCTCCTCCACTTCCA
GGAATGCGGATGCCATTCAGTGGTCCTGTGCCTCCACCACCTCCCCTGGGATTCCTTGGA
GGACAAAATTCTCCTCCTCTACCAATCCTGCCATTTGGGTTGAAACCAAAGAAAGAATTT
AAACCTGAAATCAGCATGAGAAGATTGAATTGGTTAAAGATCAGACCTCATGAAATGACT
GAAAACTGTTTCTGGATAAAAGTAAATGAAAATAAGTATGAAAACGTGGATTTGCTTTGT
AAACTTGAGAATACATTTTGTTGCCAACAAAAAGAGAGAAGAGAAGAGGAAGATATTGAA
GAGAAGAAATCGATTAAGAAAAAAATTAAAGAACTTAAGTTTTTAGATTCTAAAATTGCC
CAGAACCTTTCAATCTTCCTGAGCTCTTTTCGGGTGCCATATGAGGAAATCAGAATGATG
ATATTGGAAGTAGATGAAACACGGTTGGCAGAGTCTATGATTCAGAACTTAATAAAGCAT
CTTCCTGATCAAGAGCAATTAAATTCATTGTCTCAGTTCAAGAGTGAATATAGCAACTTA
TGTGAACCTGAGCAGTTTGTGGTTGTGATGAGCAATGTGAAGAGACTACGGCCACGGCTC
AGTGCTATTCTCTTTAAGCTTCAGTTTGAAGAGCAGGTGAACAACATCAAACCTGACATC
ATGGCTGTCAGTACTGCCTGCGAAGAGATAAAGAAGAGCAAAAGCTTTAGCAAGTTGCTG
GAACTTGTATTGCTAATGGGAAACTACATGAATGCTGGCTCCCGGAATGCTCAAACCTTC
GGATTTAACCTTAGCTCTCTCTGTAAACTAAAGGACACAAAATCAGCAGATCAGAAAACA
ACGCTACTTCATTTCCTGGTAGAAATATGTGAAGAGAAGTACCCTGATATACTGAATTTT
GTGGATGATTTGGAACCTTTAGACAAAGCTAGTAAAGTCTCTGTAGAAACGCTGGAAAAG
AATTTGAGGCAGATGGGAAGGCAGCTTCAACAGCTTGAGAAGGAATTGGAAACCTTTCCC
CCTCCTGAGGACTTGCATGACAAGTTTGTGACAAAGATGTCCAGATTTGTTATCAGTGCA
AAAGAACAATATGAGACACTTTCGAAGTTACACGAAAACATGGAAAAGTTATACCAGAGT
ATAATAGGATACTATGCCATTGATGTGAAGAAGGTGTCTGTGGAAGACTTTCTTACTGAC
CTGAATAACTTCAGAACCACATTCATGCAAGCAATAAAGGAGAATATCAAAAAAAGAGAA
GCAGAGGAAAAAGAAAAACGTGTCAGAATAGCTAAAGAATTAGCAGAGCGAGAAAGACTC
GAACGCCAACAAAAGAAAAAGCGTTTATTAGAAATGAAGACTGAGGGTGATGAGACAGGA
GTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAAAA
AGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTT
CTGAAAGTTTGTAACCATGAAAATCAGAAAGTGCAGTTGACAGAAGGGTCACGTTCACAC
TACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATCTA
GACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTA
GAAAGCAACAGAAAAAAGGAAACGGAACTTCTTGGCTCTTTTTCTAAAAATGAATCAGTT
CCCGAAGTTGAAGCCCTGCTGGCAAGATTACGAGCTTTATAA
Protein Properties
Number of Residues 1193
Molecular Weight 136924.6
Theoretical pI 7.04
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Protein diaphanous homolog 3
MERHQPRLHHPAQGSAAGTPYPSSASLRGCRESKMPRRKGPQHPPPPSGPEEPGEKRPKF
HLNIRTLTDDMLDKFASIRIPGSKKERPPLPNLKTAFASSDCSAAPLEMMENFPKPLSEN
ELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQYINTASKTGSLKRSRQISPQEFI
HELKMGSADERLVTCLESLRVSLTSNPVSWVESFGHEGLGLLLDILEKLISGKIQEKVVK
KNQHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGE
ESILEEVLEALTSAGEEKKIDRFFCIVEGLRHNSVQLQVACMQLINALVTSPDDLDFRLH
IRNEFMRCGLKEILPNLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDV
YNMVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFT
YRKRLDLDLTQFVDICIDQAKLEEFEEKASELYKKFEKEFTDHQETQAELQKKEAKINEL
QAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLP
GMRMPFSGPVPPPPPLGFLGGQNSPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMT
ENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIA
QNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNL
CEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLL
ELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNF
VDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISA
KEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKRE
AEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEGDETGVMDNLLEALQSGAAFRDRRK
RTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNL
DTHTSTGRIKAAEKKEACNVESNRKKETELLGSFSKNESVPEVEALLARLRAL
GenBank ID Protein 110225351
UniProtKB/Swiss-Prot ID Q9NSV4
UniProtKB/Swiss-Prot Entry Name DIAP3_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001042517.1
GeneCard ID DIAPH3
GenAtlas ID DIAPH3
HGNC ID HGNC:15480
References
General References
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