Hmdb loader
Identification
HMDB Protein ID HMDBP08358
Secondary Accession Numbers
  • 14070
Name Dedicator of cytokinesis protein 7
Synonyms Not Available
Gene Name DOCK7
Protein Type Unknown
Biological Properties
General Function Involved in guanyl-nucleotide exchange factor activity
Specific Function Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization
Pathways Not Available
Reactions Not Available
GO Classification
Function
purine nucleotide binding
binding
nucleotide binding
guanyl nucleotide binding
guanyl ribonucleotide binding
gtp binding
enzyme regulator activity
protein binding
gtpase binding
enzyme binding
nucleoside-triphosphatase regulator activity
gtpase regulator activity
guanyl-nucleotide exchange factor activity
Cellular Location
  1. Cell projection
  2. axon
Gene Properties
Chromosome Location Chromosome:1
Locus 1p31.3
SNPs DOCK7
Gene Sequence
>6330 bp
ATGGCCGAGCGCCGCGCCTTCGCCCAGAAGATCAGCAGAACGGTGGCAGCCGAAGTTAGG
AAGCAGATCTCCGGACAATATAGTGGTTCTCCCCAACTGCTCAAAAACCTTAATATTGTT
GGCAATATATCCCATCACACCACAGTGCCCCTTACCGAAGCAGTAGATCCAGTGGATTTG
GAAGATTACCTCATTACTCATCCTTTGGCTGTGGATTCTGGGCCTTTACGGGATTTGATT
GAATTTCCTCCAGATGATATTGAAGTTGTTTATAGTCCTCGGGACTGCAGAACTCTTGTT
TCAGCTGTACCTGAAGAAAGTGAAATGGATCCACATGTTAGAGACTGTATAAGAAGTTAT
ACAGAAGACTGGGCAATTGTCATCAGAAAATATCATAAATTGGGAACAGGATTTAATCCC
AATACATTAGATAAACAGAAAGAAAGGCAAAAAGGTTTGCCAAAACAAGTTTTTGAATCT
GATGAAGCTCCAGATGGCAACAGCTACCAGGATGATCAAGATGACCTTAAAAGACGTTCA
ATGTCAATAGATGATACCCCAAGGGGTAGCTGGGCCTGTAGTATCTTTGACTTGAAAAAT
TCACTTCCTGATGCTTTGCTTCCCAATTTACTTGATCGAACTCCAAATGAAGAAATAGAC
CGTCAGAATGATGACCAAAGGAAATCAAACCGTCACAAAGAACTTTTTGCTTTGCATCCA
TCACCAGATGAGGAAGAACCAATAGAACGGCTTAGTGTTCCTGATATACCCAAAGAACAT
TTTGGTCAAAGACTTCTTGTAAAATGCTTATCACTCAAGTTTGAAATTGAAATTGAACCC
ATTTTTGCAAGTTTGGCTTTATATGATGTCAAGGAAAAGAAAAAGATTTCAGAAAACTTT
TATTTTGACCTTAATTCTGAGCAGATGAAAGGGTTGTTACGTCCACATGTACCACCTGCT
GCCATTACTACCCTGGCAAGATCAGCAATTTTTTCTATCACTTATCCTTCCCAAGATGTT
TTTCTTGTAATAAAGCTAGAAAAAGTCCTACAGCAAGGAGACATTGGAGAGTGTGCAGAA
CCATATATGATTTTCAAAGAAGCAGATGCCACCAAGAATAAAGAAAAACTGGAGAAACTG
AAGAGTCAAGCAGATCAGTTTTGCCAAAGACTTGGGAAATATCGCATGCCTTTTGCTTGG
ACTGCAATCCATTTAATGAATATTGTTAGCAGTGCTGGGAGTTTGGAAAGAGATTCTACA
GAAGTAGAAATCAGTACTGGAGAACGAAAAGGGTCTTGGTCAGAGAGGAGGAATTCTAGT
ATTGTTGGCAGACGATCACTTGAAAGGACAACAAGTGGAGATGATGCTTGTAACTTGACG
AGCTTTCGACCAGCTACTCTCACAGTGACAAATTTTTTTAAGCAGGAAGGAGACCGCTTA
AGTGATGAAGATCTCTACAAATTCCTTGCTGATATGAGAAGGCCATCTTCTGTCTTACGG
CGACTAAGACCTATTACAGCTCAGCTCAAGATAGACATTTCTCCCGCACCTGAAAATCCC
CATTATTGCCTAACTCCGGAGCTGCTTCAAGTGAAGCTTTACCCTGACAGTAGAGTTAGA
CCTACCAGAGAAATCTTAGAGTTTCCCGCAAGGGATGTTTATGTTCCAAACACTACTTAC
AGAAATCTTCTCTACATATACCCTCAGAGTCTTAATTTTGCCAATCGTCAAGGTTCTGCT
AGAAATATAACAGTGAAAGTCCAGTTTATGTATGGAGAGGATCCAAGCAATGCCATGCCG
GTAATCTTTGGTAAATCTAGCTGTTCAGAATTTTCAAAGGAAGCCTATACAGCCGTAGTA
TATCATAACAGGTCTCCTGATTTTCATGAAGAAATCAAGGTTAAGCTTCCTGCTACTTTA
ACTGACCATCATCACTTGCTTTTTACTTTTTATCATGTTAGTTGTCAACAAAAACAAAAT
ACTCCTCTTGAAACACCAGTTGGATATACATGGATACCAATGCTTCAGAATGGACGGTTG
AAGACTGGCCAGTTTTGCTTGCCAGTCTCATTGGAAAAACCACCACAGGCTTATTCTGTA
CTGTCTCCTGAGGTTCCTCTACCTGGCATGAAATGGGTAGATAATCACAAAGGTGTTTTT
AATGTTGAAGTTGTTGCTGTTTCGTCTATCCATACACAAGATCCTTATCTTGACAAATTT
TTTGCTCTGGTCAATGCTCTGGATGAACACCTGTTCCCAGTCCGAATTGGGGACATGCGA
ATCATGGAAAATAACTTAGAAAATGAATTGAAGAGCAGTATTTCAGCACTGAATTCATCC
CAGCTGGAACCAGTGGTCCGATTTCTTCATCTTCTGCTAGATAAACTGATACTTTTAGTT
ATTAGACCTCCTGTCATTGCTGGCCAAATAGTTAACCTAGGTCAAGCATCTTTTGAAGCC
ATGGCATCAATTATAAATCGACTTCACAAAAACTTGGAAGGAAATCATGACCAGCATGGC
AGAAACAGCCTTCTTGCATCATATATTCATTATGTTTTCCGCCTACCAAATACTTACCCT
AATTCATCATCACCAGGTCCTGGGGGTTTGGGAGGATCAGTGCATTATGCCACAATGGCT
AGATCTGCGGTGAGACCTGCAAGCCTTAATTTAAATCGTTCTCGAAGCCTTAGTAATAGC
AATCCAGATATATCTGGGACTCCCACGTCACCAGATGATGAAGTTCGATCAATCATCGGG
AGTAAGGCTATGGATCGAAGTTGTAATCGTATGTCTTCGCACACAGAGACGTCAAGTTTC
TTACAAACATTAACGGGACGCTTACCAACTAAAAAGCTTTTTCACGAGGAGCTGGCTTTG
CAGTGGGTTGTTTGCAGTGGCAGCGTTCGGGAATCAGCTTTGCAACAAGCCTGGTTCTTT
TTTGAATTAATGGTAAAGAGCATGGTGCACCATTTATACTTTAATGATAAACTTGAGGCT
CCAAGGAAAAGTCGTTTTCCAGAACGTTTCATGGATGACATTGCAGCTCTTGTCAGCACG
ATTGCTAGTGATATAGTTTCACGATTTCAGAAGGACACAGAAATGGTTGAGAGACTCAAT
ACAAGCCTTGCATTCTTTCTCAATGATCTGTTGTCTGTTATGGACAGAGGATTTGTTTTT
AGCCTTATAAAGTCCTGCTATAAACAGGTGTCTTCAAAGCTTTACTCATTACCGAATCCC
AGTGTTCTGGTGTCCTTGAGGCTGGATTTTCTACGAATCATCTGCAGTCATGAGCACTAT
GTTACATTAAACTTACCCTGCAGCTTACTTACTCCACCTGCATCTCCATCACCTTCTGTT
TCTTCTGCAACATCTCAGAGTTCTGGATTTTCTACGAATGTACAAGACCAAAAGATTGCA
AATATGTTTGAATTATCCGTGCCTTTCCGCCAACAGCATTATTTGGCAGGACTTGTGTTA
ACAGAGCTGGCTGTCATTTTAGACCCTGATGCTGAAGGACTGTTTGGATTGCATAAGAAA
GTCATCAATATGGTACACAATTTACTCTCCAGTCACGACTCAGACCCGCGGTACTCTGAC
CCTCAGATAAAGGCTCGAGTGGCCATGTTGTATCTACCTCTGATTGGTATTATCATGGAA
ACTGTACCTCAGCTGTATGATTTTACAGAAACTCACAATCAACGAGGAAGACCAATTTGT
ATAGCCACTGATGATTATGAAAGTGAGAGCGGAAGTATGATAAGCCAGACCGTTGCCATG
GCAATCGCAGGGACATCGGTCCCTCAACTAACAAGGCCTGGCAGTTTCCTCCTCACGTCA
ACGAGTGGCAGGCAACACACTACCTTTTCAGCAGAATCAAGTCGAAGCCTTTTGATCTGT
CTACTTTGGGTTCTCAAAAATGCAGATGAAACAGTTCTACAGAAGTGGTTTACAGATCTC
TCAGTCTTGCAGCTAAACCGGCTATTAGATCTGCTTTATCTCTGTGTGTCTTGCTTTGAG
TATAAAGGGAAAAAAGTGTTTGAACGAATGAATAGCTTGACCTTTAAGAAATCAAAAGAC
ATGAGAGCAAAGCTTGAAGAAGCTATTCTTGGGAGCATAGGTGCCAGGCAAGAAATGGTA
CGGCGAAGCCGAGGACAGCTCGGTACGTACACAATAGCTTCTCCTCCTGAGAGAAGCCCA
TCTGGAAGTGCCTTTGGAAGTCAAGAAAATTTGAGGTGGAGGAAAGATATGACTCACTGG
CGTCAAAACACAGAGAAGCTTGACAAATCAAGAGCAGAGATTGAACACGAAGCACTGATT
GATGGAAACCTGGCTACAGAAGCAAACCTAATCATTTTAGATACATTAGAGATTGTTGTT
CAGACCGTTTCTGTAACGGAATCCAAAGAGAGCATTCTTGGTGGAGTGCTAAAAGTGCTA
CTACACAGCATGGCCTGTAACCAAAGTGCAGTTTATCTACAACACTGTTTTGCTACACAG
AGAGCCTTGGTTTCAAAGTTTCCTGAACTCTTATTTGAAGAAGAGACAGAGCAGTGTGCT
GATTTATGCCTCAGGCTTCTCCGACACTGTAGCAGTAGCATCGGTACAATACGGTCACAC
GCCAGTGCCTCCCTTTACCTACTAATGAGGCAAAACTTTGAGATTGGGAATAACTTTGCC
AGGGTTAAAATGCAGGTAACAATGTCACTATCCTCCTTGGTGGGCACATCTCAGAATTTT
AATGAAGAATTCTTAAGACGTTCTCTAAAGACTATATTGACATATGCTGAAGAAGATCTG
GAATTGAGGGAAACAACATTTCCTGATCAGGTCCAGGATCTGGTTTTCAATCTCCATATG
ATTCTTTCTGATACTGTGAAAATGAAGGAACACCAGGAGGATCCTGAAATGTTGATTGAT
CTAATGTACAGAATTGCCAAGGGTTACCAGACCTCTCCAGATCTGCGATTGACCTGGTTG
CAGAACATGGCAGGCAAGCACTCAGAACGAAGCAATCATGCTGAAGCTGCACAGTGTCTA
GTCCACTCAGCAGCACTTGTTGCTGAATATTTGAGCATGCTGGAGGACCGGAAATATCTT
CCTGTGGGATGTGTAACATTTCAGAATATTTCATCTAATGTTTTAGAAGAATCTGCGGTC
TCAGATGATGTGGTATCTCCAGATGAAGAAGGTATCTGCTCTGGAAAATACTTTACTGAG
TCAGGACTTGTGGGATTACTGGAACAAGCAGCTGCTTCCTTCTCTATGGCTGGCATGTAT
GAAGCAGTTAATGAAGTTTACAAAGTACTTATTCCTATTCATGAAGCTAATCGGGATGCA
AAGAAACTATCCACAATTCATGGTAAACTTCAAGAAGCATTCAGCAAAATTGTTCATCAG
AGTACTGGCTGGGAGCGGATGTTTGGCACCTATTTTCGTGTTGGTTTTTATGGAACCAAG
TTCGGGGATTTGGATGAACAAGAATTTGTTTACAAGGAGCCTGCAATAACCAAACTTGCA
GAGATATCTCACAGATTGGAGGGATTTTACGGAGAAAGATTTGGAGAGGATGTGGTTGAA
GTAATCAAAGACTCTAATCCTGTAGACAAGTGTAAATTAGATCCTAACAAGGCATATATT
CAGATTACCTATGTGGAGCCATACTTTGACACATATGAGATGAAGGACAGAATCACCTAT
TTCGACAAAAATTACAATCTTCGTCGATTCATGTACTGTACACCCTTTACTTTAGATGGC
CGTGCCCATGGGGAACTTCATGAACAATTCAAAAGGAAGACCATTCTGACTACGTCTCAT
GCCTTTCCTTATATTAAAACAAGGGTCAATGTCACTCATAAAGAAGAGATCATCTTAACA
CCAATTGAAGTTGCTATTGAGGACATGCAGAAAAAGACACAGGAGTTGGCATTTGCAACA
CATCAGGATCCCGCAGACCCCAAAATGCTTCAGATGGTACTCCAGGGATCTGTAGGCACC
ACAGTGAATCAGGGGCCTTTGGAAGTTGCCCAGGTTTTTCTGTCTGAAATACCTAGTGAC
CCAAAGCTCTTCAGACATCATAATAAACTGCGACTCTGCTTTAAAGATTTTACTAAAAGG
TGTGAAGATGCCTTAAGAAAAAATAAGAGCTTAATTGGGCCGGATCAAAAGGAGTATCAA
AGGGAACTGGAGAGAAACTATCATCGCCTTAAAGAGGCCCTACAGCCACTGATCAACAGA
AAGATCCCTCAGTTATACAAGGCAGTATTGCCTGTCACCTGCCACAGAGATTCCTTCAGT
CGAATGAGCCTTCGCAAAATGGATCTCTAA
Protein Properties
Number of Residues 2140
Molecular Weight 242558.3
Theoretical pI 6.78
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Dedicator of cytokinesis protein 7
MAERRAFAQKISRTVAAEVRKQISGQYSGSPQLLKNLNIVGNISHHTTVPLTEAVDPVDL
EDYLITHPLAVDSGPLRDLIEFPPDDIEVVYSPRDCRTLVSAVPEESEMDPHVRDCIRSY
TEDWAIVIRKYHKLGTGFNPNTLDKQKERQKGLPKQVFESDEAPDGNSYQDDQDDLKRRS
MSIDDTPRGSWACSIFDLKNSLPDALLPNLLDRTPNEEIDRQNDDQRKSNRHKELFALHP
SPDEEEPIERLSVPDIPKEHFGQRLLVKCLSLKFEIEIEPIFASLALYDVKEKKKISENF
YFDLNSEQMKGLLRPHVPPAAITTLARSAIFSITYPSQDVFLVIKLEKVLQQGDIGECAE
PYMIFKEADATKNKEKLEKLKSQADQFCQRLGKYRMPFAWTAIHLMNIVSSAGSLERDST
EVEISTGERKGSWSERRNSSIVGRRSLERTTSGDDACNLTSFRPATLTVTNFFKQEGDRL
SDEDLYKFLADMRRPSSVLRRLRPITAQLKIDISPAPENPHYCLTPELLQVKLYPDSRVR
PTREILEFPARDVYVPNTTYRNLLYIYPQSLNFANRQGSARNITVKVQFMYGEDPSNAMP
VIFGKSSCSEFSKEAYTAVVYHNRSPDFHEEIKVKLPATLTDHHHLLFTFYHVSCQQKQN
TPLETPVGYTWIPMLQNGRLKTGQFCLPVSLEKPPQAYSVLSPEVPLPGMKWVDNHKGVF
NVEVVAVSSIHTQDPYLDKFFALVNALDEHLFPVRIGDMRIMENNLENELKSSISALNSS
QLEPVVRFLHLLLDKLILLVIRPPVIAGQIVNLGQASFEAMASIINRLHKNLEGNHDQHG
RNSLLASYIHYVFRLPNTYPNSSSPGPGGLGGSVHYATMARSAVRPASLNLNRSRSLSNS
NPDISGTPTSPDDEVRSIIGSKGLDRSNSWVNTGGPKAAPWGSNPSPSAESTQAMDRSCN
RMSSHTETSSFLQTLTGRLPTKKLFHEELALQWVVCSGSVRESALQQAWFFFELMVKSMV
HHLYFNDKLEAPRKSRFPERFMDDIAALVSTIASDIVSRFQKDTEMVERLNTSLAFFLND
LLSVMDRGFVFSLIKSCYKQVSSKLYSLPNPSVLVSLRLDFLRIICSHEHYVTLNLPCSL
LTPPASPSPSVSSATSQSSGFSTNVQDQKIANMFELSVPFRQQHYLAGLVLTELAVILDP
DAEGLFGLHKKVINMVHNLLSSHDSDPRYSDPQIKARVAMLYLPLIGIIMETVPQLYDFT
ETHNQRGRPICIATDDYESESGSMISQTVAMAIAGTSVPQLTRPGSFLLTSTSGRQHTTF
SAESSRSLLICLLWVLKNADETVLQKWFTDLSVLQLNRLLDLLYLCVSCFEYKGKKVFER
MNSLTFKKSKDMRAKLEEAILGSIGARQEMVRRSRGQLGTYTIASPPERSPSGSAFGSQE
NLRWRKDMTHWRQNTEKLDKSRAEIEHEALIDGNLATEANLIILDTLEIVVQTVSVTESK
ESILGGVLKVLLHSMACNQSAVYLQHCFATQRALVSKFPELLFEEETEQCADLCLRLLRH
CSSSIGTIRSHASASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTSQNFNEEFLRRSL
KTILTYAEEDLELRETTFPDQVQDLVFNLHMILSDTVKMKEHQEDPEMLIDLMYRIAKGY
QTSPDLRLTWLQNMAGKHSERSNHAEAAQCLVHSAALVAEYLSMLEDRKYLPVGCVTFQN
ISSNVLEESAVSDDVVSPDEEGICSGKYFTESGLVGLLEQAAASFSMAGMYEAVNEVYKV
LIPIHEANRDAKKLSTIHGKLQEAFSKIVHQSTGWERMFGTYFRVGFYGTKFGDLDEQEF
VYKEPAITKLAEISHRLEGFYGERFGEDVVEVIKDSNPVDKCKLDPNKAYIQITYVEPYF
DTYEMKDRITYFDKNYNLRRFMYCTPFTLDGRAHGELHEQFKRKTILTTSHAFPYIKTRV
NVTHKEEIILTPIEVAIEDMQKKTQELAFATHQDPADPKMLQMVLQGSVGTTVNQGPLEV
AQVFLSEIPSDPKLFRHHNKLRLCFKDFTKRCEDALRKNKSLIGPDQKEYQRELERNYHR
LKEALQPLINRKIPQLYKAVLPVTCHRDSFSRMSLRKMDL
GenBank ID Protein 54112429
UniProtKB/Swiss-Prot ID Q96N67
UniProtKB/Swiss-Prot Entry Name DOCK7_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID DOCK7
GenAtlas ID DOCK7
HGNC ID HGNC:19190
References
General References
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  4. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [PubMed:19608861 ]
  5. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  6. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
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  9. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
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  12. Watabe-Uchida M, John KA, Janas JA, Newey SE, Van Aelst L: The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18. Neuron. 2006 Sep 21;51(6):727-39. [PubMed:16982419 ]
  13. Nellist M, Burgers PC, van den Ouweland AM, Halley DJ, Luider TM: Phosphorylation and binding partner analysis of the TSC1-TSC2 complex. Biochem Biophys Res Commun. 2005 Aug 5;333(3):818-26. [PubMed:15963462 ]
  14. Cote JF, Vuori K: Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. J Cell Sci. 2002 Dec 15;115(Pt 24):4901-13. [PubMed:12432077 ]