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Identification
HMDB Protein ID HMDBP08401
Secondary Accession Numbers
  • 14113
Name Guanine nucleotide-binding protein subunit beta-4
Synonyms
  1. Transducin beta chain 4
Gene Name GNB4
Protein Type Unknown
Biological Properties
General Function Involved in signal transducer activity
Specific Function Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:3
Locus 3q26.33
SNPs GNB4
Gene Sequence
>1023 bp
ATGAGCGAGCTGGAGCAGCTGAGGCAGGAGGCTGAACAGCTTCGGAATCAGATCCAGGAT
GCTCGGAAGGCCTGCAATGATGCCACGCTGGTTCAGATCACGTCTAATATGGACTCCGTG
GGCCGAATACAAATGCGAACAAGGCGCACGCTGCGCGGCCACCTCGCTAAGATCTACGCC
ATGCACTGGGGATATGATTCCAGGCTACTAGTCAGTGCTTCGCAAGATGGAAAATTAATT
ATTTGGGATAGCTATACGACAAATAAGATGCACGCCATCCCTCTGAGGTCCTCCTGGGTG
ATGACCTGTGCCTACGCCCCGTCCGGGAACTACGTTGCCTGTGGAGGCTTGGATAACATC
TGCTCCATATACAACCTAAAGACCCGAGAGGGGAATGTGCGGGTGAGCCGAGAATTGCCA
GGACACACGGGCTACTTGTCCTGCTGCCGATTCTTAGATGATGGACAAATCATTACAAGT
TCGGGAGACACGACTTGTGCTTTGTGGGACATTGAGACCGGACAGCAGACTACGACCTTC
ACGGGACACTCGGGTGACGTGATGAGCCTCTCACTGAGTCCTGACTTGAAGACCTTTGTG
TCTGGTGCTTGTGATGCATCCTCAAAGCTGTGGGATATCCGAGATGGGATGTGTAGACAG
TCTTTCACCGGACACATCTCAGACATCAACGCTGTCAGTTTCTTCCCGAGTGTATATGCC
TTTGCCACTGGTTCTGATGATGCCACATGCCGACTCTTTGACCTCCGTGCAGACCAGGAG
CTCCTGCTATACTCTCATGACAATATCATCTGTGGCATTACTTCTGTGGCCTTCTCAAAG
AGTGGGCGCCTCCTGTTAGCCGGCTATGACGACTTCAACTGCAGTGTGTGGGACGCTCTG
AAAGGAGGCCGGTCAGGTGTCCTTGCTGGTCATGACAACCGTGTTAGCTGCTTAGGTGTG
ACTGATGACGGCATGGCTGTGGCCACTGGCTCCTGGGACAGTTTTCTTAGAATCTGGAAT
TGA
Protein Properties
Number of Residues 340
Molecular Weight 37566.8
Theoretical pI 5.85
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Guanine nucleotide-binding protein subunit beta-4
MSELEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQMRTRRTLRGHLAKIYA
MHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNI
CSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTF
TGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYA
FATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTL
KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN
GenBank ID Protein 20257506
UniProtKB/Swiss-Prot ID Q9HAV0
UniProtKB/Swiss-Prot Entry Name GBB4_HUMAN
PDB IDs
GenBank Gene ID AF501886
GeneCard ID GNB4
GenAtlas ID GNB4
HGNC ID HGNC:20731
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Ruiz-Velasco V, Ikeda SR, Puhl HL: Cloning, tissue distribution, and functional expression of the human G protein beta 4-subunit. Physiol Genomics. 2002 Feb 11;8(1):41-50. [PubMed:11842130 ]