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Identification
HMDB Protein ID HMDBP08414
Secondary Accession Numbers
  • 14126
Name Interferon-induced guanylate-binding protein 1
Synonyms
  1. GBP-1
  2. GTP-binding protein 1
  3. Guanine nucleotide-binding protein 1
  4. HuGBP-1
Gene Name GBP1
Protein Type Unknown
Biological Properties
General Function Involved in GTPase activity
Specific Function Binds GTP, GDP and GMP
Pathways Not Available
Reactions Not Available
GO Classification
Function
purine nucleotide binding
binding
nucleotide binding
catalytic activity
hydrolase activity
guanyl nucleotide binding
guanyl ribonucleotide binding
gtp binding
gtpase activity
nucleoside-triphosphatase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity
Cellular Location
  1. Cell membrane
  2. Lipid-anchor
  3. Cytoplasmic side (Potential)
Gene Properties
Chromosome Location Chromosome:1
Locus 1p22.2
SNPs GBP1
Gene Sequence
>1779 bp
ATGGCATCAGAGATCCACATGACAGGCCCAATGTGCCTCATTGAGAACACTAATGGGCGA
CTGATGGCGAATCCAGAAGCTCTGAAGATCCTTTCTGCCATTACACAGCCTATGGTGGTG
GTGGCAATTGTGGGCCTCTACCGCACAGGCAAATCCTACCTGATGAACAAGCTGGCTGGA
AAGAAAAAGGGCTTCTCTCTGGGCTCCACGGTGCAGTCTCACACTAAAGGAATCTGGATG
TGGTGTGTGCCCCACCCCAAGAAGCCAGGCCACATCCTAGTTCTGCTGGACACCGAGGGT
CTGGGAGATGTAGAGAAGGGTGACAACCAGAATGACTCCTGGATCTTCGCCCTGGCCGTC
CTCCTGAGCAGCACCTTCGTGTACAATAGCATAGGAACCATCAACCAGCAGGCTATGGAC
CAACTGTACTATGTGACAGAGCTGACACATAGAATCCGATCAAAATCCTCACCTGATGAG
AATGAGAATGAGGTTGAGGATTCAGCTGACTTTGTGAGCTTCTTCCCAGACTTTGTGTGG
ACACTGAGAGATTTCTCCCTGGACTTGGAAGCAGATGGACAACCCCTCACACCAGATGAG
TACCTGACATACTCCCTGAAGCTGAAGAAAGGTACCAGTCAAAAAGATGAAACTTTTAAC
CTGCCCAGACTCTGTATCCGGAAATTCTTCCCAAAGAAAAAATGCTTTGTCTTTGATCGG
CCCGTTCACCGCAGGAAGCTTGCCCAGCTCGAGAAACTACAAGATGAAGAGCTGGACCCC
GAATTTGTGCAACAAGTAGCAGACTTCTGTTCCTACATCTTTAGTAATTCCAAAACTAAA
ACTCTTTCAGGAGGCATCCAGGTCAACGGGCCTCGTCTAGAGAGCCTGGTGCTGACCTAC
GTCAATGCCATCAGCAGTGGGGATCTGCCGTGCATGGAGAACGCAGTCCTGGCCTTGGCC
CAGATAGAGAACTCAGCTGCAGTGCAAAAGGCTATTGCCCACTATGAACAGCAGATGGGC
CAGAAGGTGCAGCTGCCCACAGAAACCCTCCAGGAGCTGCTGGACCTGCACAGGGACAGT
GAGAGAGAGGCCATTGAAGTCTTCATCAGGAGTTCCTTCAAAGATGTGGACCATCTATTT
CAAAAGGAGTTAGCGGCCCAGCTAGAAAAAAAGCGGGATGACTTTTGTAAACAGAATCAG
GAAGCATCATCAGATCGTTGCTCAGCTTTACTTCAGGTCATTTTCAGTCCTCTAGAAGAA
GAAGTGAAGGCGGGAATTTATTCGAAACCAGGGGGCTATCGTCTCTTTGTTCAGAAGCTA
CAAGACCTGAAGAAAAAGTACTATGAGGAACCGAGGAAGGGGATACAGGCTGAAGAGATT
CTGCAGACATACTTGAAATCCAAGGAGTCTATGACTGATGCAATTCTCCAGACAGACCAG
ACTCTCACAGAAAAAGAAAAGGAGATTGAAGTGGAACGTGTGAAAGCTGAGTCTGCACAG
GCTTCAGCAAAAATGTTGCAGGAAATGCAAAGAAAGAATGAGCAGATGATGGAACAGAAG
GAGAGGAGTTATCAGGAACACTTGAAACAACTGACTGAGAAGATGGAGAACGACAGGGTC
CAGTTGCTGAAAGAGCAAGAGAGGACCCTCGCTCTTAAACTTCAGGAACAGGAGCAACTA
CTAAAAGAGGGATTTCAAAAAGAAAGCAGAATAATGAAAAATGAGATACAGGATCTCCAG
ACGAAAATGAGACGACGAAAGGCATGTACCATAAGCTAA
Protein Properties
Number of Residues 592
Molecular Weight 67902.2
Theoretical pI 6.23
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Interferon-induced guanylate-binding protein 1
MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAG
KKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAV
LLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVW
TLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDR
PVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTY
VNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTESLQELLDLHRDS
EREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSGLLQVIFSPLEE
EVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQ
TLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRV
QLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS
GenBank ID Protein 158256998
UniProtKB/Swiss-Prot ID P32455
UniProtKB/Swiss-Prot Entry Name GBP1_HUMAN
PDB IDs
GenBank Gene ID AK291783
GeneCard ID GBP1
GenAtlas ID GBP1
HGNC ID HGNC:4182
References
General References
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  5. Nantais DE, Schwemmle M, Stickney JT, Vestal DJ, Buss JE: Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1. J Leukoc Biol. 1996 Sep;60(3):423-31. [PubMed:8830800 ]
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