Hmdb loader
Identification
HMDB Protein ID HMDBP08429
Secondary Accession Numbers
  • 14141
Name GTPase IMAP family member 8
Synonyms
  1. IAN-9
  2. Immune-associated nucleotide-binding protein 9
  3. Protein IanT
Gene Name GIMAP8
Protein Type Unknown
Biological Properties
General Function Involved in GTP binding
Specific Function Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections
Pathways Not Available
Reactions Not Available
GO Classification
Function
purine nucleotide binding
binding
nucleotide binding
guanyl nucleotide binding
guanyl ribonucleotide binding
gtp binding
Cellular Location
  1. Mitochondrion
  2. Golgi apparatus
  3. Endoplasmic reticulum
Gene Properties
Chromosome Location Chromosome:7
Locus 7q36.1
SNPs GIMAP8
Gene Sequence
>1998 bp
ATGTCAGAGCAGAGCTGCCAGATGTCCGAACTGCGGCTCCTCCTCCTGGGGAAATGCCGC
TCGGGAAAAAGTGCCACAGGAAATGCCATTCTGGGCAAACATGTGTTCAAGTCCAAGTTC
AGTGATCAGACAGTGATCAAAATGTGCCAGAGAGAGAGTTGGGTCCTGAGAGAAAGGAAG
GTTGTGGTAATTGACACCCCTGACCTTTTCTCCTCAATAGCTTGTGCTGAAGACAAGCAA
CGCAACATCCAACACTGCTTGGAGCTCTCTGCTCCCAGCCTCCATGCTCTGCTCTTGGTA
ATTGCCATCGGCCATTTCACAAGGGAGGATGAGGAAACAGCCAAGGGCATCCAACAAGTG
TTTGGAGCTGAAGCCAGGAGGCACATCATTATTGTCTTCACTCGGAAGGATGATTTGGGG
GATGACTTGCTGCAAGATTTCATTGAAAAAAACAAACCTCTCAAGCAGTTGGTTCAAGAC
TATGAGGGCCGATACTGCATTTTCAACAACAAGACCAATAGTAAGGATGAGCAGATCACC
CAGGTGTTGGAGCTCCTTCGCAAGGTTGAGTCTTTGGTGAATACGAACGGAGGACCCTAT
CATGTGAACTTCAAAACTGAAGGCAGCAGGTTTCAAGATTGTGTGAATGAAGCTGCATCT
CAAGAGGGAGACAAGCCACAGGGCCCAAGGGAAAGGCAGCTGCAGTCCACAGGACCCGAG
CAGAATCCGGGGACATCAGAACTGACAGTCCTCCTTGTGGGGAAACGCGGTGCTGGAAAA
AGTGCAGCAGGAAACAGCATTCTGGGGAGGCAGGCCTTTCAGACCGGATTTAGTGAGCAG
TCAGTAACCCAGAGCTTCTTGTCTGAGAGCAGAAGCTGGAGAAAAAAGAAAGTTTCGATC
ATTGATGCTCCGGACATCTCATCTTTAAAGAACATTGACTCAGAAGTTAGAAAACACATC
TGTACAGGCCCCCATGCCTTCCTGCTGGTGACACCACTGGGCTTTTACACTAAGAATGAT
GAGGCAGTGCTGAGCACCATCCAAAACAATTTTGGAGAAAAATTCTTTGAGTACATGATC
ATACTTCTTACCAGGAAAGAAGATTTAGGGGATCAGGATCTAGATACGTTCTTAAGAAAC
AGCAATAAAGCTCTCTATGGTCTCATCCAGAAGTGTAAAAACAGATATAGTGCCTTCAAC
TACCGGGCAACAGGAGAAGAAGAGCAAAGGCAGGCGGACGAGCTCCTGGAAAAAATTGAG
AGCATGGTGCATCAGAATGGGAACAAGCATTGCGTTTTCAGAGAAAAAGAAACCCTGAAC
ATTGTCCTTGTGGGGAGAAGCGGGACTGGGAAGAGTGCGACCGGGAACTCTATCCTGGGG
AGCCTCGTCTTCACCTCTCGGCTCCGGGCCCAGCCAGTCACCAAGACCAGCCAGAGTGGC
AGGAGGACATGGGACGGACAGGAGGTGGTGGTTGTGGACACTCCTTCCTTCAACCAGATG
CTGGATGTCGAAAAGGACCCATCCCGGTTAGAAGAGGAGGTCAAGCGCTGTTTGTCCTGC
TGTGAAAAAGGGGACACATTTTTTGTCCTGGTGTTCCAGCTGGGACGATTCACTGAAGAG
GACAAAACAGCTGTGGCGAAACTGGAGGCCATCTTTGGAGCAGACTTTACGAAATACGCG
ATTATGCTGTTCACCCGGAAGGAAGACCTAGGGGCGGGGAATTTGGAAGACTTCATGAAG
AACTCAGATAACAAAGCCCTTCGGCGCATTTTTAAAAAGTGTGGGCGGCGAGTTTGTGCT
TTTAACAACAAAGAAACAGGCCAGGCCCAGGAAACCCAGGTGAAAGCTCTTTTAACAAAG
GTCAATGATCTGAGAAAAGAAAGTGGGTGGTCCGGGTATCCCCATACACAGGAGAACGTC
AGCAAACTAATTAAAAATGTCCAGGAAATGTCCCAAGCCGAAAAACTCCTTAAAAATTTA
ATAGGTATTTTACAATAG
Protein Properties
Number of Residues 665
Molecular Weight 74889.6
Theoretical pI 8.47
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>GTPase IMAP family member 8
MSEQSCQMSELRLLLLGKCRSGKSATGNAILGKHVFKSKFSDQTVIKMCQRESWVLRERK
VVVIDTPDLFSSIACAEDKQRNIQHCLELSAPSLHALLLVIAIGHFTREDEETAKGIQQV
FGAEARRHIIIVFTRKDDLGDDLLQDFIEKNKPLKQLVQDYEGRYCIFNNKTNSKDEQIT
QVLELLRKVESLVNTNGGPYHVNFKTEGSRFQDCVNEAASQEGDKPQGPRERQLQSTGPE
QNPGTSELTVLLVGKRGAGKSAAGNSILGRQAFQTGFSEQSVTQSFLSESRSWRKKKVSI
IDAPDISSLKNIDSEVRKHICTGPHAFLLVTPLGFYTKNDEAVLSTIQNNFGEKFFEYMI
ILLTRKEDLGDQDLDTFLRNSNKALYGLIQKCKNRYSAFNYRATGEEEQRQADELLEKIE
SMVHQNGNKHCVFREKETLNIVLVGRSGTGKSATGNSILGSLVFTSRLRAQPVTKTSQSG
RRTWDGQEVVVVDTPSFNQMLDVEKDPSRLEEEVKRCLSCCEKGDTFFVLVFQLGRFTEE
DKTAVAKLEAIFGADFTKYAIMLFTRKEDLGAGNLEDFMKNSDNKALRRIFKKCGRRVCA
FNNKETGQAQETQVKALLTKVNDLRKESGWSGYPHTQENVSKLIKNVQEMSQAEKLLKNL
IGILQ
GenBank ID Protein 77680753
UniProtKB/Swiss-Prot ID Q8ND71
UniProtKB/Swiss-Prot Entry Name GIMA8_HUMAN
PDB IDs Not Available
GenBank Gene ID AJ633686
GeneCard ID GIMAP8
GenAtlas ID GIMAP8
HGNC ID HGNC:21792
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  3. Dion C, Carter C, Hepburn L, Coadwell WJ, Morgan G, Graham M, Pugh N, Anderson G, Butcher GW, Miller JR: Expression of the Ian family of putative GTPases during T cell development and description of an Ian with three sets of GTP/GDP-binding motifs. Int Immunol. 2005 Sep;17(9):1257-68. Epub 2005 Aug 15. [PubMed:16103028 ]