Hmdb loader
Identification
HMDB Protein ID HMDBP08433
Secondary Accession Numbers
  • 14145
Name Guanine nucleotide-binding protein-like 3-like protein
Synonyms Not Available
Gene Name GNL3L
Protein Type Unknown
Biological Properties
General Function Involved in GTP binding
Specific Function Required for normal processing of ribosomal pre-rRNA. Required for cell proliferation. Binds GTP
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular
Function
purine nucleotide binding
binding
nucleotide binding
guanyl nucleotide binding
guanyl ribonucleotide binding
gtp binding
Cellular Location
  1. Nucleus
  2. nucleolus
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs GNL3L
Gene Sequence
>1749 bp
ATGATGAAACTTAGACACAAAAATAAAAAGCCAGGTGAAGGTTCCAAGGGCCACAAGAAG
ATAAGTTGGCCCTACCCTCAGCCTGCAAAGCAAAATGGGAAGAAAGCAACCTCCAAAGTG
CCCTCTGCACCTCATTTTGTTCACCCCAATGATCATGCCAATCGAGAGGCTGAATTAAAG
AAGAAGTGGGTTGAGGAGATGAGGGAGAAGCAGCAAGCCGCCCGGGAGCAAGAAAGACAA
AAACGCAGGACCATTGAGAGCTACTGTCAGGATGTCCTAAGACGCCAGGAGGAGTTTGAG
CATAAGGAGGAAGTTTTGCAGGAATTAAATATGTTTCCTCAGCTGGATGACGAGGCCACG
AGGAAGGCTTATTACAAGGAGTTCCGTAAGGTGGTGGAATACTCTGATGTGATTCTGGAA
GTCCTGGATGCCAGAGACCCATTAGGCTGCCGCTGCTTCCAAATGGAGGAGGCTGTCCTG
CGAGCACAAGGCAACAAGAAGCTGGTCCTGGTCTTGAACAAGATTGACCTGGTCCCCAAG
GAGGTTGTGGAGAAATGGCTGGATTACCTTCGGAATGAGTTGCCAACCGTGGCTTTCAAG
GCCAGTACCCAGCATCAGGTCAAAAACCTGAATCGTTGCAGTGTGCCAGTAGATCAGGCC
TCTGAGTCACTGCTGAAAAGCAAAGCCTGCTTTGGAGCTGAAAACCTCATGAGGGTTCTG
GGGAACTATTGCCGCCTTGGTGAAGTGCGCACCCACATTCGTGTGGGTGTTGTGGGTCTT
CCCAATGTTGGGAAGAGCAGCCTGATCAATAGCCTGAAGCGCAGCCGCGCATGCAGCGTG
GGAGCTGTTCCTGGAATTACCAAATTCATGCAGGAGGTCTACCTGGACAAGTTCATCCGG
CTCTTGGATGCTCCAGGCATTGTCCCAGGGCCCAACTCAGAGGTGGGCACCATCCTGCGT
AACTGCGTCCACGTGCAGAAGCTGGCAGACCCTGTGACCCCAGTGGAGACCATCCTGCAG
CGCTGCAACCTGGAGGAGATTTCCAACTATTATGGCGTCTCTGGGTTCCAGACCACTGAG
CACTTTCTGACGGCAGTGGCCCACCGTTTGGGGAAGAAGAAGAAGGGAGGCTTATATAGT
CAGGAACAGGCGGCCAAAGCTGTCCTAGCTGACTGGGTGAGCGGGAAGATCAGCTTCTAT
ATACCACCACCAGCCACTCACACTCTGCCCACCCATCTCAGTGCTGAGATCGTTAAGGAA
ATGACCGAGGTCTTTGACATCGAGGATACTGAGCAGGCCAATGAAGACACCATGGAATGC
TTGGCCACCGGAGAATCTGATGAGCTGTTGGGTGACACGGACCCACTTGAAATGGAGATC
AAGTTGCTCCATTCTCCGATGACGAAAATAGCAGATGCCATTGAAAATAAAACCACCGTG
TATAAGATTGGAGATCTCACTGGGTATTGCACCAATCCAAACCGTCATCAGATGGGGTGG
GCTAAACGCAATGTGGACCACCGCCCTAAGAGCAACAGTATGGTGGATGTCTGCTCAGTG
GACCGCCGCTCAGTGCTGCAGAGGATCATGGAGACGGACCCCCTGCAACAGGGCCAGGCT
CTGGCATCTGCCCTGAAAAATAAGAAGAAGATGCAGAAACGTGCAGATAAAATCGCCAGC
AAGCTGTCTGATTCCATGATGTCTGCTCTCGACCTCTCTGGCAATGCTGATGATGGTGTT
GGTGACTAA
Protein Properties
Number of Residues 582
Molecular Weight 65572.7
Theoretical pI 8.62
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Guanine nucleotide-binding protein-like 3-like protein
MMKLRHKNKKPGEGSKGHKKISWPYPQPAKQNGKKATSKVPSAPHFVHPNDHANREAELK
KKWVEEMREKQQAAREQERQKRRTIESYCQDVLRRQEEFEHKEEVLQELNMFPQLDDEAT
RKAYYKEFRKVVEYSDVILEVLDARDPLGCRCFQMEEAVLRAQGNKKLVLVLNKIDLVPK
EVVEKWLDYLRNELPTVAFKASTQHQVKNLNRCSVPVDQASESLLKSKACFGAENLMRVL
GNYCRLGEVRTHIRVGVVGLPNVGKSSLINSLKRSRACSVGAVPGITKFMQEVYLDKFIR
LLDAPGIVPGPNSEVGTILRNCVHVQKLADPVTPVETILQRCNLEEISNYYGVSGFQTTE
HFLTAVAHRLGKKKKGGLYSQEQAAKAVLADWVSGKISFYIPPPATHTLPTHLSAEIVKE
MTEVFDIEDTEQANEDTMECLATGESDELLGDTDPLEMEIKLLHSPMTKIADAIENKTTV
YKIGDLTGYCTNPNRHQMGWAKRNVDHRPKSNSMVDVCSVDRRSVLQRIMETDPLQQGQA
LASALKNKKKMQKRADKIASKLSDSMMSALDLSGNADDGVGD
GenBank ID Protein 7022755
UniProtKB/Swiss-Prot ID Q9NVN8
UniProtKB/Swiss-Prot Entry Name GNL3L_HUMAN
PDB IDs Not Available
GenBank Gene ID AK001475
GeneCard ID GNL3L
GenAtlas ID GNL3L
HGNC ID HGNC:25553
References
General References
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  6. Du X, Rao MR, Chen XQ, Wu W, Mahalingam S, Balasundaram D: The homologous putative GTPases Grn1p from fission yeast and the human GNL3L are required for growth and play a role in processing of nucleolar pre-rRNA. Mol Biol Cell. 2006 Jan;17(1):460-74. Epub 2005 Oct 26. [PubMed:16251348 ]
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