Hmdb loader
Identification
HMDB Protein ID HMDBP08438
Secondary Accession Numbers
  • 14150
Name GTP-binding protein 1
Synonyms
  1. G-protein 1
  2. GP-1
  3. GP1
Gene Name GTPBP1
Protein Type Unknown
Biological Properties
General Function Involved in GTPase activity
Specific Function Not Available
Pathways Not Available
Reactions Not Available
GO Classification
Function
purine nucleotide binding
binding
nucleotide binding
catalytic activity
hydrolase activity
guanyl nucleotide binding
guanyl ribonucleotide binding
gtp binding
gtpase activity
nucleoside-triphosphatase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location Chromosome:2
Locus 22q13.1
SNPs GTPBP1
Gene Sequence
>2010 bp
ATGGCGACGGAGCGCAGTCGCTCCGCGATGGACTCGCCGGTCCCGGCCTCTATGTTCGCC
CCCGAGCCCAGCTCCCCGGGGGCGGCCAGGGCCGCGGCGGCCGCCGCCCGACTCCACGGC
GGCTTTGACTCGGACTGCAGCGAGGACGGCGAGGCGCTCAACGGCGAGCCAGAGCTGGAC
CTCACCAGCAAGCTGGTTCTAGTGAGCCCTACATCAGAGCAGTATGACAGCCTACTTCGG
CAGATGTGGGAGAGGATGGACGAGGGATGCGGAGAGACCATATATGTCATTGGGCAGGGA
TCAGATGGGACTGAGTATGGGCTGAGTGAAGCTGACATGGAGGCCTCCTACGCCACAGTG
AAGAGCATGGCGGAACAGATAGAGGCCGATGTCATCCTTCTGCGGGAACGGCAAGAAGCT
GGGGGCCGCGTGCGTGATTACCTGGTCCGGAAACGAGTAGGAGACAATGACTTCCTGGAG
GTCAGGGTAGCAGTGGTGGGCAACGTGGATGCTGGCAAAAGCACGCTTCTGGGGGTCCTG
ACACATGGGGAGCTGGACAATGGCCGAGGCTTTGCCCGCCAGAAACTCTTCCGCCACAAA
CATGAAATTGAATCTGGTCGCACCAGCAGTGTGGGCAACGACATTCTGGGCTTTGACAGT
GAAGGCAATGTAGTGAACAAGCCTGACAGCCACGGCGGCAGCCTGGAGTGGACCAAGATC
TGTGAGAAGTCCACGAAAGTCATTACCTTCATCGACTTGGCTGGTCATGAGAAGTACCTG
AAAACCACTGTCTTCGGCATGACAGGCCATCTGCCTGACTTCTGCATGCTCATGGTGGGC
AGCAATGCTGGCATCGTGGGGATGACCAAAGAACACCTGGGCTTGGCACTGGCACTCAAT
GTACCTGTCTTTGTGGTAGTCACCAAGATTGACATGTGTCCTGCCAACATCCTGCAAGAA
ACCCTGAAGCTGTTACAGCGCCTGCTGAAGTCACCAGGCTGCCGGAAGATCCCCGTGCTG
GTGCAGAGCAAAGATGATGTGATTGTCACAGCCTCCAACTTCAGCTCTGAAAGGATGTGC
CCGATATTCCAGATCTCCAACGTTACAGGCGAGAACCTAGATCTGCTGAAGATGTTCCTC
AACCTCCTCTCCCCCCGCACCAGCTACAGGGAGGAGGAGCCTGCTGAGTTTCAGATTGAT
GACACCTACTCCGTCCCGGGTGTGGGGACAGTGGTTTCGGGGACAACACTGAGAGGCCTG
ATCAAGCTGAATGACACGCTGCTGCTGGGCCCAGACCCCTTGGGTAACTTCCTGTCCATT
GCTGTCAAATCCATCCATCGCAAGCGCATGCCTGTCAAGGAGGTGCGGGGTGGCCAGACA
GCATCCTTTGCGCTGAAGAAGATCAAGCGCTCGTCCATCCGGAAGGGCATGGTGATGGTT
TCCCCACGTTTGAATCCCCAAGCCTCCTGGGAGTTTGAGGCCGAGATTCTCGTCCTCCAC
CACCCCACCACAATTAGCCCGCGCTACCAGGCCATGGTGCACTGTGGGAGCATCAGGCAG
ACAGCCACCATTCTGAGCATGGACAAGGACTGTCTGCGCACTGGGGACAAGGCCACTGTA
CACTTCCGCTTCATCAAGACCCCTGAGTACCTGCACATAGACCAGCGGCTGGTGTTCCGG
GAAGGCCGCACCAAGGCTGTCGGCACCATCACCAAGCTCCTCCAGACCACCAACAACTCC
CCAATGAACTCCAAGCCGCAGCAGATTAAAATGCAGTCGACGAAAAAGGGCCCCCTGACG
AAACGAGACGAGGGGGGCCCGTCTGGTGGGCCAGCAGTAGGAGCACCCCCACCTGGAGAT
GAAGCCTCCTCTGTAGGGGCAGGGCAACCAGCTGCGTCCAGCAATCTCCAGCCTCAGCCT
AAGCCCAGCAGTGGAGGCCGGCGACGAGGGGGCCAGCGCCACAAGGTGAAGTCCCAGGGG
GCCTGTGTGACTCCTGCCAGCGGCTGCTGA
Protein Properties
Number of Residues 669
Molecular Weight 72453.3
Theoretical pI 8.47
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>GTP-binding protein 1
MATERSRSAMDSPVPASMFAPEPSSPGAARAAAAAARLHGGFDSDCSEDGEALNGEPELD
LTSKLVLVSPTSEQYDSLLRQMWERMDEGCGETIYVIGQGSDGTEYGLSEADMEASYATV
KSMAEQIEADVILLRERQEAGGRVRDYLVRKRVGDNDFLEVRVAVVGNVDAGKSTLLGVL
THGELDNGRGFARQKLFRHKHEIESGRTSSVGNDILGFDSEGNVVNKPDSHGGSLEWTKI
CEKSTKVITFIDLAGHEKYLKTTVFGMTGHLPDFCMLMVGSNAGIVGMTKEHLGLALALN
VPVFVVVTKIDMCPANILQETLKLLQRLLKSPGCRKIPVLVQSKDDVIVTASNFSSERMC
PIFQISNVTGENLDLLKMFLNLLSPRTSYREEEPAEFQIDDTYSVPGVGTVVSGTTLRGL
IKLNDTLLLGPDPLGNFLSIAVKSIHRKRMPVKEVRGGQTASFALKKIKRSSIRKGMVMV
SPRLNPQASWEFEAEILVLHHPTTISPRYQAMVHCGSIRQTATILSMDKDCLRTGDKATV
HFRFIKTPEYLHIDQRLVFREGRTKAVGTITKLLQTTNNSPMNSKPQQIKMQSTKKGPLT
KRDEGGPSGGPAVGAPPPGDEASSVGAGQPAASSNLQPQPKPSSGGRRRGGQRHKVKSQG
ACVTPASGC
GenBank ID Protein 123228951
UniProtKB/Swiss-Prot ID O00178
UniProtKB/Swiss-Prot Entry Name GTPB1_HUMAN
PDB IDs Not Available
GenBank Gene ID AL021707
GeneCard ID GTPBP1
GenAtlas ID GTPBP1
HGNC ID HGNC:4669
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  3. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  4. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [PubMed:17081983 ]
  5. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al.: The DNA sequence of human chromosome 22. Nature. 1999 Dec 2;402(6761):489-95. [PubMed:10591208 ]
  6. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
  7. Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I: A genome annotation-driven approach to cloning the human ORFeome. Genome Biol. 2004;5(10):R84. Epub 2004 Sep 30. [PubMed:15461802 ]
  8. Senju S, Nishimura Y: Identification of human and mouse GP-1, a putative member of a novel G-protein family. Biochem Biophys Res Commun. 1997 Feb 13;231(2):360-4. [PubMed:9070279 ]