Hmdb loader
Identification
HMDB Protein ID HMDBP08441
Secondary Accession Numbers
  • 14153
Name GTP-binding protein 5
Synonyms
  1. ObgH1
  2. Protein obg homolog 1
Gene Name GTPBP5
Protein Type Unknown
Biological Properties
General Function Involved in magnesium ion binding
Specific Function Involved in the ribosome maturation process. Plays a role of GTPase in vitro. When missing, mitochondria elongation and abnormal nuclear morphology are observed
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular
Function
ion binding
cation binding
metal ion binding
purine nucleotide binding
binding
nucleotide binding
catalytic activity
hydrolase activity
guanyl nucleotide binding
guanyl ribonucleotide binding
gtp binding
magnesium ion binding
gtpase activity
nucleoside-triphosphatase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity
Cellular Location
  1. Mitochondrion
Gene Properties
Chromosome Location Chromosome:2
Locus 20q13.33
SNPs GTPBP5
Gene Sequence
>1221 bp
ATGGCACCTGCAAGGTGTTTCTCAGCAAGATTGAGGACCGTGTTTCAGGGCGTGGGGCAT
TGGGCTTTGTCCACATGGGCTGGCCTGAAGCCCAGCCGGCTACTGCCACAGCGGGCTTCT
CCCAGGCTGCTCTCGGTCGGCCGTGCGGACCTCGCCAAGCATCAGGAACTCCCGGGGAAG
AAGCTGCTCTCTGAGAAAAAGCTGAAAAGGTACTTTGTGGACTATCGGAGAGTGCTTGTC
TGTGGAGGAAACGGAGGCGCTGGGGCAAGCTGCTTCCACAGTGAGCCCCGCAAGGAGTTT
GGAGGCCCTGATGGAGGGGACGGAGGCAACGGTGGACACGTCATTCTGAGAGTTGACCAG
CAAGTCAAGTCCCTGTCGTCGGTCCTGTCGCGGTACCAGGGTTTCAGTGGAGAAGATGGA
GGGAGTAAAAACTGCTTCGGGCGCAGTGGCGCCGTCCTCTACATCCGGGTCCCCGTGGGC
ACGCTGGTGAAGGAGGGAGGCAGAGTTGTGGCCGACCTGTCTTGCGTGGGAGATGAGTAC
ATTGCCGCGCTGGGCGGGGCAGGAGGGAAAGGCAACCGCTTCTTCCTGGCCAACAACAAC
CGTGCCCCTGTGACCTGTACCCCTGGACAGCCAGGACAGCAGCGAGTTCTCCACCTGGAG
CTCAAGACGGTGGCCCACGCCGGAATGGTGGGATTCCCCAACGCCGGGAAGTCCTCACTG
CTCCGGGCCATTTCAAACGCCAGACCCGCCGTGGCTTCCTACCCGTTCACCACCCTGAAG
CCCCACGTCGGGATCGTCCACTACGAAGGCCACCTACAAATAGCAGTGGCCGACATCCCC
GGCATCATACGAGGCGCCCACCAGAACAGGGGTCTGGGGTCCGCCTTCCTCAGGCACATC
GAGCGCTGCCGCTTTCTCTTGTTCGTGGTGGATCTTTCTCAGCCTGAGCCGTGGACTCAA
GTTGACGATTTAAAATATGAACTGGAGATGTATGAAAAGGGCCTGTCTGCGAGGCCCCAC
GCAATCGTCGCAAACAAGATTGACCTCCCTGAAGCCCAAGCCAATCTGTCCCAGCTCCGG
GATCACTTGGGACAGGAGGTCATCGTGCTGTCGGCGTTGACCGGCGAGAACCTGGAGCAG
CTGCTGTTGCACCTGAAGGTGCTGTATGACGCCTACGCGGAGGCCGAGCTGGGCCAGGGC
CGCCAGCCGCTCAGGTGGTAG
Protein Properties
Number of Residues 406
Molecular Weight 43955.1
Theoretical pI 9.89
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>GTP-binding protein 5
MAPARCFSARLRTVFQGVGHWALSTWAGLKPSRLLPQRASPRLLSVGRADLAKHQELPGK
KLLSEKKLKRYFVDYRRVLVCGGNGGAGASCFHSEPRKEFGGPDGGDGGNGGHVILRVDQ
QVKSLSSVLSRYQGFSGEDGGSKNCFGRSGAVLYIRVPVGTLVKEGGRVVADLSCVGDEY
IAALGGAGGKGNRFFLANNNRAPVTCTPGQPGQQRVLHLELKTVAHAGMVGFPNAGKSSL
LRAISNARPAVASYPFTTLKPHVGIVHYEGHLQIAVADIPGIIRGAHQNRGLGSAFLRHI
ERCRFLLFVVDLSQPEPWTQVDDLKYELEMYEKGLSARPHAIVANKIDLPEAQANLSQLR
DHLGQEVIVLSALTGENLEQLLLHLKVLYDAYAEAELGQGRQPLRW
GenBank ID Protein 24308117
UniProtKB/Swiss-Prot ID Q9H4K7
UniProtKB/Swiss-Prot Entry Name GTPB5_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_015666.3
GeneCard ID GTPBP5
GenAtlas ID GTPBP5
HGNC ID HGNC:16239
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE, Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C, Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A, Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA, Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S, Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K, Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A, Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM, Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ, Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE, Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C, Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L, Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA, Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S, Rogers J: The DNA sequence and comparative analysis of human chromosome 20. Nature. 2001 Dec 20-27;414(6866):865-71. [PubMed:11780052 ]
  4. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  5. Hirano Y, Ohniwa RL, Wada C, Yoshimura SH, Takeyasu K: Human small G proteins, ObgH1, and ObgH2, participate in the maintenance of mitochondria and nucleolar architectures. Genes Cells. 2006 Nov;11(11):1295-304. [PubMed:17054726 ]