Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP08452
Secondary Accession Numbers
  • 14164
Name Eukaryotic translation initiation factor 2 subunit 3-like protein
Synonyms
  1. Eukaryotic translation initiation factor 2 subunit gamma A
  2. eIF-2-gamma A
  3. eIF-2gA
Gene Name EIF2S3L
Protein Type Unknown
Biological Properties
General Function Involved in GTPase activity
Specific Function eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B
Pathways Not Available
Reactions Not Available
GO Classification
Function
purine nucleotide binding
binding
nucleotide binding
catalytic activity
hydrolase activity
guanyl nucleotide binding
guanyl ribonucleotide binding
gtp binding
gtpase activity
nucleoside-triphosphatase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs EIF2S3L
Gene Sequence
>1419 bp
ATGGCGGGCGGAGAAGCTGGAGTGACTCTAGGGCAGCCGCATCTTTCGCGTCAGGATCTC
ACCACCTTGGATGTTACCAAGTTGACGCCACTTTCACACGAAGTTATCAGCAGACAAGCC
ACAATTAACATAGGTACAATTGGTCATGTAGCTCATGGGAAATCCACAGTCGTCAAAGCT
ATTTCTGGAGTTCATACTGTCAGGTTCAAAAATGAACTAGAAAGAAATATTACAATCAAG
CTTGGATATGCTAATGCTAAGATTTATAAGCTTGATGACCCAAGTTGCCCTCGGCCAGAA
TGTTATAGATCTTGTGGGAGCAGTACACCTGACGAGTTTCCTACGGACATTCCAGGGACC
AAAGGGAACTTCAAATTAGTCAGACATGTTTCCTTTGTTGACTGTCCTGGCCACGATATT
TTGATGGCTACTATGCTGAACGGTGCAGCAGTGATGGATGCAGCTCTTCTGTTGATAGCT
GGTAATGAATCTTGCCCTCAGCCTCAGACATCGGAACACCTGGCTGCTATAGAGATCATG
AAACTGAAGCATATTTTGATTCTACAAAATAAAATTGATTTGGTAAAAGAAAGTCAGGCT
AAAGAACAATACGAGCAGATCCTTGCATTTGTCCAAGGTACAGTAGCAGAGGGAGCTCCC
ATTATTCCAATTTCAGCTCAGCTGAAATACAATATTGAAGTTGTTTGTGAGTACATAGTA
AAGAAAATTCCAGTACCCCCAAGAGACTTTACTTCAGAGCCCCGGCTTATTGTTATTAGA
TCTTTTGATGTCAACAAACCTGGCTGTGAAGTTGATGACCTTAAGGGAGGTGTAGCTGGT
GGTAGTATCCTAAAAGGAGTATTAAAGGTGGGCCAGGAGATAGAAGTAAGACCTGGTATT
GTTTCCAAAGATAGTGAAGGAAAACTCATGTGTAAACCAATCTTTTCCAAAATTGTATCA
CTTTTTGCGGAGCATAATGATCTGCAATATGCTGCTCCAGGCGGTCTTATTGGAGTTGGA
ACAAAAATTGACCCCACTTTGTGCCGGGCTGACAGAATGGTGGGGCAAGTACTTGGTGCA
GTCGGAGCTTTACCTGAGATATTCACAGAATTGGAAATTTCCTATTTCCTGCTTAGACGG
CTTCTAGGTGTACGCACTGAAGGAGACAAGAAAGCAGCAAAGGTTCAAAAGCTGTCTAAG
AATGAAGTGCTCATGGTGAACATAGGATCCCTGTCAACAGGAGGGAGAGTTAGTGCTGTC
AAGGCCGATTTGGGTAAAATTGTTTTGACCAATCCAGTGTGCACAGAGGTAGGAGAAAAA
ATTGCCCTTAGCCGAAGAGTTGAAAAACACTGGCGTTTAATTGGTTGGGGTCAGATAAGA
AGAGGAGTGACAATCAAGCCAACAGTAGATGATGACTGA
Protein Properties
Number of Residues 472
Molecular Weight 51228.2
Theoretical pI 8.54
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Eukaryotic translation initiation factor 2 subunit 3-like protein
MAGGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKA
ISGVHTVRFKNELERNITIKLGYANAKIYQLDDPSCPRPECYRSCGSSMPDEFPTDIPGT
KGNFRLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIM
KLKHILILQNKIDLVKERQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIV
KKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQETEVRPGI
VSKDSEGKLMCKSIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQILGA
VGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAV
KADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQIRRGVTIKPTVDDD
GenBank ID Protein 4503507
UniProtKB/Swiss-Prot ID Q2VIR3
UniProtKB/Swiss-Prot Entry Name IF2GL_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001415
GeneCard ID EIF2S3L
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  5. Ehrmann IE, Ellis PS, Mazeyrat S, Duthie S, Brockdorff N, Mattei MG, Gavin MA, Affara NA, Brown GM, Simpson E, Mitchell MJ, Scott DM: Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution. Hum Mol Genet. 1998 Oct;7(11):1725-37. [PubMed:9736774 ]