Hmdb loader
Identification
HMDB Protein ID HMDBP08465
Secondary Accession Numbers
  • 14177
Name Importin-4
Synonyms
  1. Imp4
  2. Imp4b
  3. Importin-4b
  4. Ran-binding protein 4
  5. RanBP4
Gene Name IPO4
Protein Type Unknown
Biological Properties
General Function Involved in binding
Specific Function Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
protein transporter activity
transporter activity
substrate-specific transporter activity
Process
establishment of localization
transport
protein transport
intracellular protein transport
Cellular Location
  1. Nucleus
  2. Cytoplasm
Gene Properties
Chromosome Location Chromosome:1
Locus 14q12
SNPs IPO4
Gene Sequence
>3246 bp
ATGGAGTCAGCCGGGCTAGAGCAGCTCCTACGGGAGCTGCTGCTACCGGACACCGAGCGC
ATCCGTCGGGCCACGGAACAGCTCCAGATCGTTCTTCGGGCCCCCGCCGCTTTGCCGGCT
CTCTGCGACCTGCTAGCCTCGGCGGCCGACCCCCAGATCCGCCAGTTTGCGGCCGTGCTG
ACCCGCAGACGACTGAACACCCGCTGGCGACGGCTGGCGGCGGAGCAACGGGAGAGCCTC
AAGTCCCTGATCCTGACGGCCCTGCAGAGAGAAACAGAGCACTGTGTGAGCCTCAGCCTG
GCCCAGCTCTCAGCCACCATTTTTCGAAAGGAAGGCTTGGAGGCCTGGCCACAGCTTTTG
CAGCTGCTTCAGCACAGTACCCACAGCCCCCACAGCCCAGAGAGAGAGATGGGGCTTTTG
CTGCTAAGTGTGGTGGTGACCTCCCGGCCCGAGGCCTTCCAACCCCACCACCGGGAGCTT
CTTCGGCTTCTGAATGAGACTCTTGGTGAGGTGGGCTCTCCTGGGCTGCTCTTCTACTCC
CTGCGCACTCTGACCACCATGGCTCCCTACCTCAGCACTGAAGATGTGCCTCTCGCTCGG
ATGTTGGTGCCCAAGCTGATCATGGCCATGCAGACTCTGATCCCCATAGATGAGGCAAAG
GCCTGTGAGGCCCTTGAGGCTTTGGATGAACTGTTGGAGTCAGAGGTGCCGGTCATCACC
CCCTACCTCTCTGAAGTCCTCACATTCTGCCTGGAGGTAGCTAGAAATGTGGCCCTGGGC
AATGCGATACGCATACGTATTCTCTGCTGCCTCACTTTCTTGGTCAAAGTCAAGAGCAAG
GCCTTACTGAAGAATCGTCTCCTGCCACCCTTGCTGCACACCCTTTTCCCCATTGTGGCT
GCTGAGCCCCCACCAGGCCAGTTGGATCCCGAGGACCAGGATTCAGAAGAGGAAGAGTTG
GAGATTGAGCTGATGGGGGAGACTCCCAAGCATTTCGCTGTACAAGTTGTGGACATGCTG
GCACTACACCTGCCCCCCGAGAAGCTCTGTCCCCAGCTGATGCCCATGTTGGAAGAGGCT
TTGCGGAGCGAGAGCCCATACCAGCGCAAAGCTGGACTCCTGGTGCTGGCCGTGCTGTCT
GACGGAGCTGGCGACCACATCAGGCAGAGACTGCTGCCCCCACTGCTGCAGATTGTGTGC
AAGGGCCTGGAGGACCCCTCGCAAGTTGTACGCAATGCTGCGCTGTTTGCCCTGGGCCAG
TTCTCAGAAAACCTACAGCCCCATATCAGCAGCTATTCAAGGGAGGTAATGCCACTGCTC
CTCGCCTACTTGAAGTCGGTGCCTCTTGGACACACACACCACCTAGCCAAGGCCTGCTAT
GCCCTGGAGAATTTTGTGGAGAACCTAGGGCCCAAGGTGCAGCCCTACCTTCCGGAGCTT
ATGGAATGCATGCTGCAGCTTCTGAGGAACCCCAGCAGTCCCCGGGCCAAGGAGCTGGCT
GTGAGCGCCCTGGGAGCCATTGCTACGGCTGCCCAGGTCTCGCTGCTGCCCTACTTCCCT
GCCATCATGGAGCACCTGCGGGAATTCCTGTTAACAGGCCGTGAGGACCTTCAGCCTGTG
CAGATCCAGAGCCTGGAGACACTGGGGGTGCTGGCACGAGCAGTGGGGGAGCCCATGAGG
CCGCTGGCTGAGGAATGCTGCCAGCTGGGTCTGGGCCTCTGCGACCAGGTAGACGACGCT
GACTTGCGGCGCTGCACGTACAGCCTATTTGCAGCCTTATCGGGTCTGATGGGTGAGGGC
CTGGCGCCCCACTTGGAACAGATCACCACGCTCATGCTGCTGTCACTGCGTTCCACCGAG
GGCATTGTGCCTCAGTATGACGGGAGCAGCTCCTTCCTTCTGTTTGACGATGAGAGTGAT
GGGGAAGAAGAGGAGGAGCTCATGGATGAGGATGTGGAAGAAGAGGATGACTCAGAGATC
TCAGGGTACAGCGTGGAGAATGCCTTCTTCGATGAGAAGGAAGACACCTGTGCTGCCGTG
GGGGAGATCTCTGTGAACACCAGTGTGGCCTTCCTTCCATACATGGAAAGTGTCTTTGAA
GAAGTATTTAAACTGCTGGAGTGCCCTCACCTGAATGTGCGGAAGGCAGCCCATGAGGCT
CTGGGTCAGTTTTGCTGTGCACTGCACAAGGCCTGTCAAAGCTGCCCCTCGGAACCCAAC
ACTGCTGCTTTGCAGGCTGCCCTGGCCCGAGTCGTGCCATCCTACATGCAGGCAGTGAAC
AGGGAGCGGGAACGCCAGGTGGTGATGGCCGTGCTGGAGGCCCTGACAGGGGTGCTCCGC
AGCTGTGGGACCCTCACACTGAAGCCCCCTGGGCGCCTCGCTGAGCTCTGTGGCGTGCTC
AAGGCTGTGCTGCAGAGGAAGACAGCCTGTCAGGATACTGACGAGGAGGAGGAAGAGGAA
GATGATGATCAGGCTGAATACGACGCCATGTTGCTGGAGCACGCTGGAGAGGCCATCCCT
GCCCTGGCAGCCGCGGCTGGGGGAGACTCCTTTGCCCCATTCTTTGCCGGTTTCCTGCCA
TTATTGGTGTGCAAGACAAAACAGGGCTGCACAGTGGCAGAGAAGTCCTTTGCAGTGGGG
ACCTTGGCAGAGACTATTCAGGGCCTGGGTGCTGCCTCAGCCCAGTTTGTGTCTCGGCTG
CTCCCTGTGCTGTTGAGCACCGCCCAAGAGGCAGACCCCGAGGTGCGAAGCAATGCCATC
TTCGGGATGGGCGTGCTGGCAGAGCATGGGGGCCACCCTGCCCAGGAACACTTCCCCAAG
CTGCTGGGGCTCCTTTTTCCCCTCCTGGCGCGGGAGCGACATGATCGTGTCCGTGACAAC
ATCTGTGGGGCACTTGCCCGCCTGTTGATGGCCAGTCCCACCAGGAAACCAGAGCCCCAG
GTGCTGGCTGCCCTACTGCATGCCCTGCCACTGAAGGAGGACTTGGAGGAGTGGGTCACC
ATTGGGCGCCTCTTCAGCTTCCTGTACCAGAGCAGCCCTGACCAGGTTATAGATGTGGCT
CCCGAGCTTCTGCGTATCTGCAGCCTCATTCTGGCTGACAACAAGATCCCACCAGACACC
AAGGCCGCACTGTTGCTGCTCCTGACGTTCCTGGCCAAACAGCACACCGACAGCTTTCAA
GCAGCTCTGGGCTCACTGCCTGTTGACAAGGCTCAGGAGCTCCAGGCTGTACTGGGCCTC
TCCTAG
Protein Properties
Number of Residues 1081
Molecular Weight 118713.8
Theoretical pI 4.6
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Importin-4
MESAGLEQLLRELLLPDTERIRRATEQLQIVLRAPAALPALCDLLASAADPQIRQFAAVL
TRRRLNTRWRRLAAEQRESLKSLILTALQRETEHCVSLSLAQLSATIFRKEGLEAWPQLL
QLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPHHRELLRLLNETLGEVGSPGLLFYS
LRTLTTMAPYLSTEDVPLARMLVPKLIMAMQTLIPIDEAKACEALEALDELLESEVPVIT
PYLSEVLTFCLEVARNVALGNAIRIRILCCLTFLVKVKSKALLKNRLLPPLLHTLFPIVA
AEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEKLCPQLMPMLEEA
LRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQ
FSENLQPHISSYSREVMPLLLAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLPEL
MECMLQLLRNPSSPRAKELAVSALGAIATAAQASLLPYFPAIMEHLREFLLTGREDLQPV
QIQSLETLGVLARAVGEPMRPLAEECCQLGLGLCDQVDDPDLRRCTYSLFAALSGLMGEG
LAPHLEQITTLMLLSLRSTEGIVPQYDGSSSFLLFDDESDGEEEEELMDEDVEEEDDSEI
SGYSVENAFFDEKEDTCAAVGEISVNTSVAFLPYMESVFEEVFKLLECPHLNVRKAAHEA
LGQFCCALHKACQSCPSEPNTAALQAALARVVPSYMQAVNRERERQVVMAVLEALTGVLR
SCGTLTLKPPGRLAELCGVLKAVLQRKTACQDTDEEEEEEDDDQAEYDAMLLEHAGEAIP
ALAAAAGGDSFAPFFAGFLPLLVCKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVSRL
LPVLLSTAQEADPEVRSNAIFGMGVLAEHGGHPAQEHFPKLLGLLFPLLARERHDRVRDN
ICGALARLLMASPTRKPEPQVLAALLHALPLKEDLEEWVTIGRLFSFLYQSSPDQVIDVA
PELLRICSLILADNKIPPDTKAALLLLLTFLAKQHTDSFQAALGSLPVDKAQELQAVLGL
S
GenBank ID Protein 18700635
UniProtKB/Swiss-Prot ID Q8TEX9
UniProtKB/Swiss-Prot Entry Name IPO4_HUMAN
PDB IDs Not Available
GenBank Gene ID AF411122
GeneCard ID IPO4
GenAtlas ID IPO4
HGNC ID HGNC:19426
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
  4. Beausoleil SA, Villen J, Gerber SA, Rush J, Gygi SP: A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat Biotechnol. 2006 Oct;24(10):1285-92. Epub 2006 Sep 10. [PubMed:16964243 ]
  5. Lischka P, Sorg G, Kann M, Winkler M, Stamminger T: A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway. J Virol. 2003 Mar;77(6):3734-48. [PubMed:12610148 ]
  6. Jakel S, Mingot JM, Schwarzmaier P, Hartmann E, Gorlich D: Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. EMBO J. 2002 Feb 1;21(3):377-86. [PubMed:11823430 ]