Hmdb loader
Identification
HMDB Protein ID HMDBP08477
Secondary Accession Numbers
  • 14189
Name Large subunit GTPase 1 homolog
Synonyms
  1. hLsg1
Gene Name LSG1
Protein Type Unknown
Biological Properties
General Function Involved in GTP binding
Specific Function GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable)
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular
Function
purine nucleotide binding
binding
nucleotide binding
guanyl nucleotide binding
guanyl ribonucleotide binding
gtp binding
Cellular Location
  1. Nucleus
  2. Cytoplasm
  3. Endoplasmic reticulum
  4. Cajal body
Gene Properties
Chromosome Location Chromosome:3
Locus 3q29
SNPs LSG1
Gene Sequence
>1977 bp
ATGGGCCGGAGGAGAGCCCCGGCCGGTGGGTCGCTGGGACGGGCCCTTATGCGCCATCAG
ACTCAGCGGAGCCGAAGCCATCGTCACACTGACTCCTGGTTGCACACAAGTGAACTCAAT
GATGGCTATGATTGGGGTCGTCTTAATCTTCAGTCAGTGACTGAACAGAGCTCCCTTGAT
GACTTCCTTGCTACTGCAGAACTTGCAGGAACAGAGTTTGTAGCTGAGAAACTTAATATT
AAGTTTGTGCCTGCTGAGGCTAGAACTGGACTACTGTCTTTCGAGGAGAGCCAGAGAATT
AAGAAGCTCCATGAAGAAAACAAACAGTTCTTGTGTATACCGAGGAGACCAAACTGGAAC
CAAAATACTACCCCAGAAGAACTCAAACAAGCAGAGAAAGATAACTTTCTAGAATGGAGA
CGTCAGCTTGTCCGGCTAGAAGAGGAACAGAAGCTGATATTGACTCCATTTGAACGAAAT
TTGGACTTTTGGCGCCAGCTCTGGAGAGTCATTGAGAGAAGTGATATTGTGGTCCAGATA
GTAGATGCTCGAAACCCACTCCTGTTTAGATGTGAGGATTTGGAATGTTATGTGAAAGAA
ATGGATGCCAATAAGGAGAACGTCATTCTGATCAACAAGGCAGACTTGCTGACTGCTGAG
CAGCGGAGTGCCTGGGCCATGTACTTCGAAAAAGAAGATGTGAAGGTTATTTTCTGGTCA
GCTTTGGCCGGAGCCATTCCCCTGAATGGTGACTCTGAGGAAGAGGCAAACAGAGATGAT
AGACAAAGCAACACAACCAAGTTTGGACATTCCAGTTTCGACCAGGCTGAAATTTCCCAC
AGTGAATCCGAACATCTCCCAGCTAGGGATTCTCCTTCACTTAGTGAAAATCCCACAACG
GATGAAGATGACAGTGAGTATGAGGACTGTCCAGAGGAGGAGGAAGACGACTGGCAGACG
TGCTCAGAAGAAGACGGTCCCAAGGAAGAGGACTGCAGCCAGGACTGGAAGGAAAGCTCT
ACTGCAGATTCTGAGGCTCGGAGCAGGAAAACCCCACAGAAGAGGCAGATACACAATTTT
AGCCATCTGGTATCCAAGCAGGAGTTACTGGAGCTCTTTAAGGAGCTACACACTGGGAGA
AAGGTGAAAGATGGGCAACTTACGGTCGGACTGGTGGGCTACCCTAATGTTGGTAAGAGT
TCAACAATCAACACCATCATGGGCAACAAGAAAGTATCTGTGTCTGCCACACCTGGTCAC
ACAAAGCACTTTCAGACTCTCTATGTGGAGCCTGGCCTCTGCCTGTGTGACTGTCCTGGC
TTGGTGATGCCATCTTTTGTGTCTACCAAGGCAGAAATGACTTGCAGCGGAATCCTCCCA
ATTGATCAGATGAGAGATCATGTTCCTCCTGTATCACTAGTTTGCCAGAATATTCCAAGA
CATGTTTTAGAAGCTACCTATGGCATTAACATCATAACGCCTAGAGAGGATGAAGATCCC
CACCGACCTCCAACATCGGAAGAACTGTTGACAGCTTATGGATACATGCGAGGATTCATG
ACAGCGCATGGACAGCCAGACCAGCCTCGATCTGCGCGCTACATCCTGAAGGACTATGTC
AGTGGTAAGCTGCTGTACTGCCATCCTCCTCCTGGAAGAGATCCTGTAACTTTTCAGCAT
CAACACCAGCGACTCCTAGAGAACAAAATGAACAGTGATGAAATAAAAATGCAGCTAGGC
AGAAATAAAAAAGCAAAGCAGATTGAAAATATCGTTGACAAAACTTTTTTCCATCAAGAG
AATGTGAGGGCTTTGACCAAAGGAGTCCAGGCTGTGATGGGTTACAAGCCCGGGAGTGGT
GTAGTGACTGCATCCACTGCGAGCTCTGAGAACGGGGCGGGGAAGCCCTGGAAAAAACAT
GGCAACAGAAATAAAAAAGAAAAAAGTCGTAGACTCTACAAGCACCTGGATATGTGA
Protein Properties
Number of Residues 658
Molecular Weight 75224.8
Theoretical pI 6.34
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Large subunit GTPase 1 homolog
MGRRRAPAGGSLGRALMRHQTQRSRSHRHTDSWLHTSELNDGYDWGRLNLQSVTEQSSLD
DFLATAELAGTEFVAEKLNIKFVPAEARTGLLSFEESQRIKKLHEENKQFLCIPRRPNWN
QNTTPEELKQAEKDNFLEWRRQLVRLEEEQKLILTPFERNLDFWRQLWRVIERSDIVVQI
VDARNPLLFRCEDLECYVKEMDANKENVILINKADLLTAEQRSAWAMYFEKEDVKVIFWS
ALAGAIPLNGDSEEEANRDDRQSNTTKFGHSSFDQAEISHSESEHLPARDSPSLSENPTT
DEDDSEYEDCPEEEEDDWQTCSEEDGPKEEDCSQDWKESSTADSEARSRKTPQKRQIHNF
SHLVSKQELLELFKELHTGRKVKDGQLTVGLVGYPNVGKSSTINTIMGNKKVSVSATPGH
TKHFQTLYVEPGLCLCDCPGLVMPSFVSTKAEMTCSGILPIDQMRDHVPPVSLVCQNIPR
HVLEATYGINIITPREDEDPHRPPTSEELLTAYGYMRGFMTAHGQPDQPRSARYILKDYV
SGKLLYCHPPPGRDPVTFQHQHQRLLENKMNSDEIKMQLGRNKKAKQIENIVDKTFFHQE
NVRALTKGVQAVMGYKPGSGVVTASTASSENGAGKPWKKHGNRNKKEKSRRLYKHLDM
GenBank ID Protein 223029424
UniProtKB/Swiss-Prot ID Q9H089
UniProtKB/Swiss-Prot Entry Name LSG1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_018385.2
GeneCard ID LSG1
GenAtlas ID LSG1
HGNC ID HGNC:25652
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  4. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A: Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Genome Res. 2001 Mar;11(3):422-35. [PubMed:11230166 ]
  6. Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA: The DNA sequence, annotation and analysis of human chromosome 3. Nature. 2006 Apr 27;440(7088):1194-8. [PubMed:16641997 ]
  7. Reynaud EG, Andrade MA, Bonneau F, Ly TB, Knop M, Scheffzek K, Pepperkok R: Human Lsg1 defines a family of essential GTPases that correlates with the evolution of compartmentalization. BMC Biol. 2005 Oct 7;3:21. [PubMed:16209721 ]