Hmdb loader

Showing Protein Rab effector MyRIP (HMDBP08489)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP08489
Secondary Accession Numbers
  • 14201
Name Rab effector MyRIP
Synonyms
  1. Exophilin-8
  2. Myosin-VIIa- and Rab-interacting protein
  3. SlaC2-c
  4. Slp homolog lacking C2 domains c
Gene Name MYRIP
Protein Type Unknown
Biological Properties
General Function Involved in Rab GTPase binding
Specific Function Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments
Pathways Not Available
Reactions Not Available
GO Classification
Function
small gtpase regulator activity
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
enzyme regulator activity
rab gtpase binding
nucleoside-triphosphatase regulator activity
gtpase regulator activity
Process
establishment of localization
transport
protein transport
intracellular protein transport
Cellular Location
  1. Cytoplasm
Gene Properties
Chromosome Location Chromosome:3
Locus 3p22.1
SNPs MYRIP
Gene Sequence 
>2580 bp
ATGGGGAGGAAGCTGGACCTGTCTGGTTTGACTGATGATGAAACAGAGCATGTTCTTCAG
GTGGTTCAAAGAGACTTCAATCTTCGCAAAAAAGAAGAAGAACGACTAAGTGAGCTGAAG
CAGAAGCTGGATGAGGAAGGCAGCAAGTGCAGCATCCTCTCGAAGCACCAGCAGTTTGTG
GAGCACTGCTGCATGCGCTGCTGCTCGCCCTTCACCTTCCTCGTCAACACCAAGCGCCAG
TGTGGAGATTGCAAATTCAATGTCTGCAAGAGCTGCTGCTCCTACCAGAAGCACGAAAAG
GCCTGGGTCTGCTGCGTCTGCCAGCAAGCGAGGCTTCTGAGGGCCCAATCTCTGGAATGG
TTCTACAATAATGTGAAGAGCCGCTTCAAGCGCTTTGGCAGTGCCAAGGTTCTGAAGAAC
CTGTACAGGAAGCACCGGCTGGAGAGTGGCGCGTGCTTCGACATTCTAGGAGGAAGCCTT
TTTGAGTCAAACCTGGAGAATGAAGGAAGCATTTCTGGCAGTGATTCAACATTTTATAGG
CAGTCAGAAGGACATAGTGTGATGGACACCTTGGCTGTGGCCCTACGGGTGGCTGAAGAG
GCCATTGAGGAAGCAATTTCCAAAGCAGAGGCATATGGGGACAGCCTGGACAAGCAAAAT
GAGGCCAGTTACCTGCGGGACCACAAGGAGGAGCTAACTGAGGAACTGGCCACGACAATC
CTGCAGAAGATTATACGAAAACAGAAGAGCAAAAGTGAGCAGCAAGTGGAAGAAGAGCCA
GGATGGCCACATCCCCAGAGTTGCAGCACAAAGGTGGCAGATGAGGGGACCTCAGCATCC
CCTGGAGGCTACCGTGCTCCCGCTGCCCTCTGGAGGTCCCAGTCTGCCTTCTCAATCACT
GGAGAAGAAGCCCTGAAGACCCCTCCAGTGGAGGCTCCATCGAGGCAGCCAAGGGACCAA
GGCCAACACCCGAGAGCAGAGTCTGCTCTGCCCAGCTGGAAGAGTGTGGACAGGCTGGAT
GAAACAAACCTGGCCCCAGTTTTGCAGAGCCCCGACGGGAACTGGGTGGCCCTGAAGGAT
GGCGCTCCACCCCCCACCCGACTACTGGCCAAACCTAAGAGCGGGACGTTTCAGGCCCTG
GAGGTGGCCTCCAGTGTGGCATCTGCCTACGATGAGATGGGCTCCGATAGCGAGGAAGAC
TTTGACTGGAGTGAGGCCTTGAGCAAGCTGTGTCCCAGGTCCCGGGCCCTGCCCAGGAAC
CCCCAGCCTCAGCCCACACAGGCCCAGAGCTCTGACCAAGGCCCCATAGCTGCCTCCCCA
TCCTCTGCACTCTCCCCCAACCCTGAGGCCATGTGCTCTGACTCGGAGACCTCCTCCGCA
GGCTCTTCCCGAGAAGTTGGGCACCAGGCCAGACTGTCCTGGTTGCAGAGGAAGGCCCCC
AGGAACCCTGCAGCTGAGAAGATGCGCTTGCATGGAGAGCTGGACGTGAACTTCAACCCC
CAGTTGGCCAGCAGGGAGACCTCGGACAGCAGCGAGCCGGAGGAGGCCCCCCACACCACA
GACCGGCGGGCCAGGAGGTGGAGAAGAGCCCGACTGGGCTCAGAAGAGCCAAGCAAAGAA
CCATCTTCCCCCAGCGCCCAGCTCCGGGATCTAGACACACATCAGGTGTCGGATGATTTA
TCAGAGACAGACATCAGCAATGAGGCTCGGGATCCCCAGACTCTCACAGACACCACAGAG
GAGAAACGGAGAAACAGGCTGTACGAGTTAGCAATGAAAATGAGTGAAAAGGAGACTTCT
TCAGGGGAGGATCAGGAGTCTGAGCCCAAGACAGAATCTGAGAACCAGAAGGAAAGTCTG
TCCTCTGAAGACAACAGCCAGAGTGTCCAGGAAGAGCTGAAGAAGAAGTTTTCTGCTGTT
TCTCTCTGCAACATCTCCACAGAAGTCCTGAAAGTCATCAATGCCACAGAGGAGTTGATA
GCAGGATCTACAGGGCCCTGGGAGTCCCCACAAGTCCCTCCTGACAGACAGAAGGGGATG
TTTCCTCGTGGGACAGACCAAGTGAGACTGGATGAGCAGCTGACTTCCCTGGAAGAAAAT
GTATACCTGGCAGCAGGCACTGTGTATGGACTGGAGACCCAGCTGACTGAGCTAGAAGAT
GCCGCCCGCTGCATCCACAGCGGCACTGATGAGACCCATCTGGCGGATCTGGAGGACCAG
GTGGCCACGGCTGCAGCCCAAGTCCACCATGCTGAACTCCAGATTTCAGATATTGAGAGC
CGGATTTCAGCCCTGACCATTGCAGGATTAAACATAGCACCATGTGTGCGCTTCACAAGA
AGACGGGATCAGAAGCAAAGGACCCAGGTACAAACCATAGATACATCAAGGCAGCAAAGG
AGGAAACTGCCTGCTCCACCGGTGAAAGCTGAAAAAATTGAGACATCTTCAGTGACTACC
ATTAAAACATTTAACCACAACTTCATTCTCCAAGGCTCCTCAACAAACAGGACTAAGGAA
AGGAAAGGCACCACCAAGGATTTGATGGAGCCTGCTCTGGAGTCAGCTGTGATGTACTGA
Protein Properties
Number of Residues 859
Molecular Weight 95705.3
Theoretical pI 5.3
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence 
>Rab effector MyRIP
MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEERLSELKQKLDEEGSKCSILSKHQQFV
EHCCMRCCSPFTFLVNTKRQCGDCKFNVCKSCCSYQKHEKAWVCCVCQQARLLRAQSLEW
FYNNVKSRFKRFGSAKVLKNLYRKHRLESGACFDILGGSLFESNLENEGSISGSDSTFYR
QSEGHSVMDTLAVALRVAEEAIEEAISKAEAYGDSLDKQNEASYLRDHKEELTEELATTI
LQKIIRKQKSKSEQQVEEEPGWPHPQSCSTKVADEGTSASPGGYRAPAALWRSQSAFSIT
GEEALKTPPVEAPSRQPRDQGQHPRAESALPSWKSVDRLDETNLAPVLQSPDGNWVALKD
GAPPPTRLLAKPKSGTFQALEVASSVASAYDEMGSDSEEDFDWSEALSKLCPRSRALPRN
PQPQPTQAQSSDQGPIAASPSSALSPNPEAMCSDSETSSAGSSREVGHQARLSWLQRKAP
RNPAAEKMRLHGELDVNFNPQLASRETSDSSEPEEAPHTTDRRARRWRRARLGSEEPSKE
PSSPSAQLRDLDTHQVSDDLSETDISNEARDPQTLTDTTEEKRRNRLYELAMKMSEKETS
SGEDQESEPKTESENQKESLSSEDNSQSVQEELKKKFSAVSLCNISTEVLKVINATEELI
AGSTGPWESPQVPPDRQKGMFPRGTDQVRLDEQLTSLEENVYLAAGTVYGLETQLTELED
AARCIHSGTDETHLADLEDQVATAAAQVHHAELQISDIESRISALTIAGLNIAPCVRFTR
RRDQKQRTQVQTIDTSRQQRRKLPAPPVKAEKIETSSVTTIKTFNHNFILQGSSTNRTKE
RKGTTKDLMEPALESAVMY
GenBank ID Protein 22779206
UniProtKB/Swiss-Prot ID Q8NFW9
UniProtKB/Swiss-Prot Entry Name MYRIP_HUMAN
PDB IDs Not Available
GenBank Gene ID AB083783
GeneCard ID MYRIP
GenAtlas ID MYRIP
HGNC ID HGNC:19156
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  3. Molina H, Horn DM, Tang N, Mathivanan S, Pandey A: Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2199-204. Epub 2007 Feb 7. [PubMed:17287340 ]
  4. El-Amraoui A, Schonn JS, Kussel-Andermann P, Blanchard S, Desnos C, Henry JP, Wolfrum U, Darchen F, Petit C: MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes. EMBO Rep. 2002 May;3(5):463-70. Epub 2002 Apr 18. [PubMed:11964381 ]
  5. Fukuda M, Kuroda TS: Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin. J Biol Chem. 2002 Nov 8;277(45):43096-103. Epub 2002 Sep 7. [PubMed:12221080 ]