Hmdb loader
Identification
HMDB Protein ID HMDBP08492
Secondary Accession Numbers
  • 14204
Name Nucleolar protein 8
Synonyms
  1. Nucleolar protein Nop132
Gene Name NOL8
Protein Type Unknown
Biological Properties
General Function Involved in nucleotide binding
Specific Function Plays an essential role in the survival of diffuse-type gastric cancer cells. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
nucleotide binding
nucleic acid binding
Cellular Location
  1. Nucleus
  2. nucleolus
Gene Properties
Chromosome Location Chromosome:9
Locus 9q22.31
SNPs NOL8
Gene Sequence
>3504 bp
ATGAAAGTGAACAGAGAAACGAAGCGCCTTTATGTGGGTGGCCTTAGCCAGGACATTTCT
GAGGCAGACCTACAAAATCAGTTCAGCAGATTTGGAGAAGTTTCGGATGTGGAGATCATC
ACACGGAAAGATGACCAAGGAAACCCACAGAAAGTTTTTGCATATATCAACATCAGTGTA
GCAGAAGCGGACCTGAAAAAATGTATGTCTGTTTTAAATAAAACAAAATGGAAAGGTGGA
ACATTACAAATTCAACTAGCAAAAGAAAGCTTTCTGCACAGATTGGCCCAAGAGAGAGAA
GCAGCAAAAGCTAAGAAAGAAGAATCAACAACAGGTAACGCCAACTTGTTAGAAAAGACA
GGAGGAGTGGATTTCCATATGAAAGCTGTGCCAGGGACAGAAGTGCCAGGGCATAAGAAT
TGGGTTGTGAGCAAATTTGGAAGAGTCTTACCTGTTCTTCACCTTAAAAATCAACATAAA
CGTAAAATCATCAAATATGATCCCTCAAAATACTGCCACAACCTGAAGAAGATAGGGGAG
GATTTCTCAAACACCATTCCTATATCCAGCCTGACTTGGGAATTAGAAGGAGGGAATGAC
CCTATGAGTAAGAAACGGCGAGGAGAGTTCTCTGACTTTCATGGCCCTCCCAAGAAGATA
ATAAAAGTGCAGAAGGATGAGAGTTCCACTGGGTCTCTGGCCATGAGTACAAGGCCCAGG
AGGGTAATAGAGAGACCACCCTTAACACAGCAACAGGCTGCACAAAAAAGAACTTGTGAT
TCCATTACTCCTTCTAAATCATCTCCTGTACCTGTTTCTGATACTCAGAAACTTAAAAAT
CTACCTTTTAAGACTTCTGGCTTGGAAACTGCCAAGAAGAGAAACAGCATTTCTGATGAT
GATACTGATTCTGAAGATGAATTGAGAATGATGATTGCGAAAGAGGAAAACTTACAGAGA
ACTACACAACCCTCAATAAATGAATCTGAAAGTGATCCTTTTGAAGTTGTAAGGGATGAT
TTCAAATCAGGCGTTCACAAACTGCATTCTTTAATAGGTTTAGGTATCAAAAATCGTGTC
TCTTGCCATGATAGTGATGATGATATTATGAGAAATGATCGTGAGTATGACTCAGGAGAT
ACAGATGAAATTATTGCGATGAAAAAAAATGTTGCTAAGGTCAAAAACAGTACAGAATTT
TCACAAATGGAAAAATCTACGAAGAAAACTTCTTTCAAAAATAGAGAAAACTGTGAGCTT
TCTGATCACTGTATTAAACTACAAAAAAGAAAAAGCAATGTAGAGTCAGCCCTCAGTCAT
GGATTAAAGTCTCTTAATCGTAAATCTCCCTCTCACTCCAGTAGCAGTGAAGATGCTGAT
TCTGCATCAGAATTAGCTGACTCTGAAGGAGGTGAGGAGTATAATGCCATGATGAAAAAC
TGCCTTCGTGTGAATCTCACTTTAGCTGATTTGGAACAATTGGCTGGCAGTGATCTGAAG
GTTCCAAATGAAGATACTAAGAGTGATGGACCAGAAACCACCACCCAATGCAAGTTTGAC
AGAGGCTCCAAGAGCCCCAAGACTCCCACTGGCCTCCGCAGAGGCCGACAGTGTATTCGT
CCTGCGGAGATTGTGGCTTCCCTGTTAGAAGGAGAGGAGAACACCTGTGGCAAACAGAAA
CCAAAGGAAAACAATTTAAAGCCAAAATTTCAGGCTTTCAAGGGAGTAGGCTGTCTATAT
GAAAAGGAGTCAATGAAAAAATCCTTGAAAGACAGTGTTGCCTCTAACAATAAAGATCAG
AATTCCATGAAACATGAGGATCCCAGTATCATATCCATGGAAGATGGGTCCCCATATGTT
AATGGCTCATTAGGTGAAGTGACTCCATGCCAACATGCAAAGAAGGCGAATGGCCCAAAC
TATATTCAGCCTCAAAAAAGACAGACCACTTTTGAAAGCCAGGATCGCAAGGCAGTGTCC
CCTAGCAGTTCTGAAAAGAGAAGTAAGAATCCTATTTCTAGGCCATTAGAAGGTAAGAAG
TCCTTAAGTCTTAGTGCAAAGACTCACAACATAGGCTTTGACAAAGACAGCTGCCATAGT
ACCACAAAGACAGAAGCTTCACAGGAAGAGCGGTCTGATTCAAGCGGCCTCACATCTCTC
AAGAAATCACCAAAGGTCTCATCCAAGGACACTCGGGAAATCAAAACTGATTTCTCACTT
TCTATTAGTAATTCGTCAGATGTGAGTGCTAAAGATAAGCATGCTGAAGACAATGAGAAG
CGTTTGGCAGCCTTGGAAGCGAGGCAAAAAGCAAAAGAAGTGCAGAAGAAGCTGGTGCAT
AATGCTCTGGCAAATTTGGATGGTCATCCAGAGGATAAGCCAACGCACATCATCTTCGGT
TCTGACAGTGAATGTGAAACAGAGGAGACATCGACTCAGGAGCAGAGCCATCCAGGAGAG
GAATGGGTGAAAGAGTCTATGGGTAAAACATCAGGGAAGCTGTTTGATAGCAGTGATGAT
GACGAATCTGATTCTGAAGATGACAGTAATAGGTTCAAAATTAAACCTCAGTTTGAGGGC
AGAGCTGGACAGAAGCTCATGGATTTACAGTCGCACTTTGGCACCGATGACAGATTCCGC
ATGGACTCTCGATTTCTAGAAACTGACAGTGAAGAGGAACAGGAAGAGGTAAATGAAAAG
AAAACTGCTGAGGAAGAAGAGCTTGCTGAAGAAAAAAAGAAAGCCCTGAATGTTGTACAA
AGTGTTTTGCAAATCAACTTAAGCAATTCTACAAACAGAGGATCAGTAGCTGCTAAGAAA
TTTAAGGACATCATACATTATGATCCAACGAAGCAAGACCATGCCACTTACGAAAGAAAA
AGAGATGATAAGCCAAAAGAAAGTAAAGCAAAACGAAAAAAGAAAAGGGAGGAAGCTGAG
AAACTACCTGAGGTGTCTAAAGAAATGTATTATAATATTGCTATGGATCTGAAAGAAATA
TTCCAAACTACAAAATATACCAGTGAAAAGGAAGAGGGCACACCCTGGAATGAGGACTGT
GGTAAAGAGAAACCTGAGGAAATCCAGGACCCTGCAGCTCTGACCAGTGACGCTGAGCAG
CCCAGCGGGTTCACGTTCTCTTTTTTTGATTCAGACACTAAAGACATAAAGGAAGAGACC
TACAGAGTTGAAACAGTGAAACCTGGAAAGATTGTCTGGCAGGAAGACCCTCGTTTACAA
GACAGCAGTTCAGAAGAGGAAGATGTTACTGAAGAAACAGATCACAGAAACTCCAGTCCT
GGAGAAGCATCATTACTTGAGAAAGAGACCACTAGATTTTTCTTTTTCTCTAAGAATGAT
GAACGACTTCAAGGTTCTGACTTATTCTGGAGAGGAGTAGGAAGTAATATGAGCAGGAAC
TCTTGGGAGGCCAGAACAACCAACCTGCGTATGGATTGTCGAAAGAAACATAAAGACGCA
AAAAGGAAAATGAAACCAAAATAA
Protein Properties
Number of Residues 1167
Molecular Weight 131615.5
Theoretical pI 7.09
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Nucleolar protein 8
MKVNRETKRLYVGGLSQDISEADLQNQFSRFGEVSDVEIITRKDDQGNPQKVFAYINISV
AEADLKKCMSVLNKTKWKGGTLQIQLAKESFLHRLAQEREAAKAKKEESTTGNANLLEKT
GGVDFHMKAVPGTEVPGHKNWVVSKFGRVLPVLHLKNQHKRKIIKYDPSKYCHNLKKIGE
DFSNTIPISSLTWELEGGNDPMSKKRRGEFSDFHGPPKKIIKVQKDESSTGSLAMSTRPR
RVIERPPLTQQQAAQKRTCDSITPSKSSPVPVSDTQKLKNLPFKTSGLETAKKRNSISDD
DTDSEDELRMMIAKEENLQRTTQPSINESESDPFEVVRDDFKSGVHKLHSLIGLGIKNRV
SCHDSDDDIMRNDREYDSGDTDEIIAMKKNVAKVKNSTEFSQMEKSTKKTSFKNRENCEL
SDHCIKLQKRKSNVESALSHGLKSLNRKSPSHSSSSEDADSASELADSEGGEEYNAMMKN
CLRVNLTLADLEQLAGSDLKVPNEDTKSDGPETTTQCKFDRGSKSPKTPTGLRRGRQCIR
PAEIVASLLEGEENTCGKQKPKENNLKPKFQAFKGVGCLYEKESMKKSLKDSVASNNKDQ
NSMKHEDPSIISMEDGSPYVNGSLGEVTPCQHAKKANGPNYIQPQKRQTTFESQDRKAVS
PSSSEKRSKNPISRPLEGKKSLSLSAKTHNIGFDKDSCHSTTKTEASQEERSDSSGLTSL
KKSPKVSSKDTREIKTDFSLSISNSSDVSAKDKHAEDNEKRLAALEARQKAKEVQKKLVH
NALANLDGHPEDKPTHIIFGSDSECETEETSTQEQSHPGEEWVKESMGKTSGKLFDSSDD
DESDSEDDSNRFKIKPQFEGRAGQKLMDLQSHFGTDDRFRMDSRFLETDSEEEQEEVNEK
KTAEEEELAEEKKKALNVVQSVLQINLSNSTNRGSVAAKKFKDIIHYDPTKQDHATYERK
RDDKPKESKAKRKKKREEAEKLPEVSKEMYYNIAMDLKEIFQTTKYTSEKEEGTPWNEDC
GKEKPEEIQDPAALTSDAEQPSGFTFSFFDSDTKDIKEETYRVETVKPGKIVWQEDPRLQ
DSSSEEEDVTEETDHRNSSPGEASLLEKETTRFFFFSKNDERLQGSDLFWRGVGSNMSRN
SWEARTTNLRMDCRKKHKDAKRKMKPK
GenBank ID Protein 45259447
UniProtKB/Swiss-Prot ID Q76FK4
UniProtKB/Swiss-Prot Entry Name NOL8_HUMAN
PDB IDs Not Available
GenBank Gene ID AB105104
GeneCard ID NOL8
GenAtlas ID NOL8
HGNC ID HGNC:23387
References
General References
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  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  4. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  5. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [PubMed:18691976 ]
  6. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [PubMed:17081983 ]
  7. Imami K, Sugiyama N, Kyono Y, Tomita M, Ishihama Y: Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column. Anal Sci. 2008 Jan;24(1):161-6. [PubMed:18187866 ]
  8. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
  9. Humphray SJ, Oliver K, Hunt AR, Plumb RW, Loveland JE, Howe KL, Andrews TD, Searle S, Hunt SE, Scott CE, Jones MC, Ainscough R, Almeida JP, Ambrose KD, Ashwell RI, Babbage AK, Babbage S, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beasley H, Beasley O, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burford D, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Chen Y, Clarke G, Clark SY, Clee CM, Clegg S, Collier RE, Corby N, Crosier M, Cummings AT, Davies J, Dhami P, Dunn M, Dutta I, Dyer LW, Earthrowl ME, Faulkner L, Fleming CJ, Frankish A, Frankland JA, French L, Fricker DG, Garner P, Garnett J, Ghori J, Gilbert JG, Glison C, Grafham DV, Gribble S, Griffiths C, Griffiths-Jones S, Grocock R, Guy J, Hall RE, Hammond S, Harley JL, Harrison ES, Hart EA, Heath PD, Henderson CD, Hopkins BL, Howard PJ, Howden PJ, Huckle E, Johnson C, Johnson D, Joy AA, Kay M, Keenan S, Kershaw JK, Kimberley AM, King A, Knights A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd C, Lloyd DM, Lovell J, Martin S, Mashreghi-Mohammadi M, Matthews L, McLaren S, McLay KE, McMurray A, Milne S, Nickerson T, Nisbett J, Nordsiek G, Pearce AV, Peck AI, Porter KM, Pandian R, Pelan S, Phillimore B, Povey S, Ramsey Y, Rand V, Scharfe M, Sehra HK, Shownkeen R, Sims SK, Skuce CD, Smith M, Steward CA, Swarbreck D, Sycamore N, Tester J, Thorpe A, Tracey A, Tromans A, Thomas DW, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Williams SA, Wilming L, Wray PW, Young L, Ashurst JL, Coulson A, Blocker H, Durbin R, Sulston JE, Hubbard T, Jackson MJ, Bentley DR, Beck S, Rogers J, Dunham I: DNA sequence and analysis of human chromosome 9. Nature. 2004 May 27;429(6990):369-74. [PubMed:15164053 ]
  10. Wang B, Malik R, Nigg EA, Korner R: Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis. Anal Chem. 2008 Dec 15;80(24):9526-33. doi: 10.1021/ac801708p. [PubMed:19007248 ]
  11. Jinawath N, Furukawa Y, Nakamura Y: Identification of NOL8, a nucleolar protein containing an RNA recognition motif (RRM), which was overexpressed in diffuse-type gastric cancer. Cancer Sci. 2004 May;95(5):430-5. [PubMed:15132771 ]
  12. Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T: A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D. J Biol Chem. 2004 Feb 27;279(9):8343-50. Epub 2003 Dec 4. [PubMed:14660641 ]