Hmdb loader
Identification
HMDB Protein ID HMDBP08507
Secondary Accession Numbers
  • 14219
Name DENN domain-containing protein 5A
Synonyms
  1. Rab6-interacting protein 1
  2. Rab6IP1
Gene Name DENND5A
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function May be involved in Rab6-mediated GTPase signaling
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:1
Locus 11p15.4
SNPs DENND5A
Gene Sequence
>3864 bp
ATGAGTGGCGGCGGCGGCGGAGGGGGCTCGGCGCCCAGTCGCTTCGCCGACTACTTTGTC
ATCTGCGGACTGGACACGGAGACCGGGCTGGAGCCGGACGAGCTGTCGGCATTATGCCAG
TACATACAGGCTTCTAAAGCCAGGGATGGTGCCAGCCCTTTCATTTCAAGTACGACTGAA
GGAGAAAATTTTGAGCAGACACCATTGAGAAGAACATTCAAATCTAAGGTCCTTGCACGA
TATCCTGAGAACGTAGAATGGAATCCCTTTGACCAAGATGCAGTAGGAATGCTATGTATG
CCGAAAGGGCTGGCATTCAAGACCCAGGCTGATCCCAGGGAGCCCCAATTCCATGCCTTT
ATTATCACAAGGGAGGATGGCTCTCGGACATTTGGGTTTGCCCTCACATTTTATGAAGAG
GTGACTAGCAAGCAGATCTGCAGTGCAATGCAGACCCTCTACCACATGCACAATGCTGAG
TATGATGTCCTACATGCTCCCCCTGCTGATGACAGAGACCAGAGCAGCATGGAGGATGGT
GAAGACACTCCTGTGACCAAACTGCAGCGCTTCAACTCCTATGACATTAGCCGGGACACT
CTCTACGTCTCTAAGTGCATCTGCCTCATCACACCCATGTCTTTCATGAAGGCATGTCGG
AGCGTGCTGGAGCAACTCCACCAGGCAGTCACTTCACCTCAGCCCCCTCCACTGCCCCTT
GAGAGCTACATATACAACGTACTCTACGAGGTGCCGCTCCCACCTCCTGGCCGGTCCTTG
AAGTTTTCTGGGGTCTATGGGCCAATAATCTGCCAGAGACCAAGTACCAATGAGCTTCCC
CTATTTGACTTTCCTGTCAAAGAGGTTTTTGAACTGCTCGGGGTGGAGAATGTGTTTCAG
CTTTTTACTTGTGCCCTTCTGGAGTTTCAAATCCTGCTCTACTCACAGCATTACCAGAGA
CTGATGACTGTGGCGGAGACGATTACAGCTCTCATGTTTCCTTTCCAGTGGCAGCATGTC
TATGTCCCTATTCTCCCAGCTTCTCTCCTGCATTTCTTAGATGCTCCTGTTCCATACCTG
ATGGGTTTGCATTCCAATGGCCTGGATGACCGGTCAAAGCTGGAGCTGCCTCAAGAGGCT
AACCTCTGCTTTGTGGACATTGACAACCACTTCATTGAGTTGCCAGAGGACTTGCCACAG
TTCCCCAACAAATTGGAGTTTGTCCAGGAAGTCTCTGAGATTCTCATGGCATTTGGAATT
CCCCCTGAAGGGAATCTTCATTGCAGTGAGAGTGCCTCCAAGCTGAAGAGGCTGCGGGCC
TCTGAGCTTGTCTCGGACAAGAGGAATGGGAACATTGCTGGCTCCCCTTTGCATTCCTAC
GAGCTTCTTAAGGAGAATGAAACTATTGCCCGGCTGCAAGCCTTGGTCAAGAGAACTGGG
GTGAGCCTGGAAAAGTTGGAAGTGCGTGAAGACCCCAGCAGCAATAAGGATCTCAAAGTT
CAGTGTGATGAAGAAGAACTCAGGATTTACCAGCTAAACATTCAGATCCGGGAAGTTTTT
GCAAATCGTTTCACTCAGATGTTTGCAGATTATGAGGTGTTTGTCATCCAACCCAGCCAG
GATAAGGAATCCTGGTTTACCAACAGGGAGCAAATGCAAAACTTTGATAAAGCATCTTTT
CTGTCAGATCAGCCTGAGCCCTACCTGCCCTTCCTCTCAAGATTCCTGGAGACCCAGATG
TTTGCATCTTTCATTGACAACAAAATAATGTGTCATGATGATGATGATAAAGACCCTGTA
CTCCGGGTATTTGATTCCCGAGTTGACAAGATCAGGCTGTTGAATGTTCGGACACCTACT
CTCCGTACATCCATGTACCAGAAGTGTACCACTGTGGATGAAGCAGAGAAAGCAATTGAG
CTGCGTCTGGCAAAAATTGACCATACTGCAATTCACCCACATTTACTTGACATGAAGATT
GGACAAGGGAAATATGAGCCGGGCTTCTTCCCTAAGCTGCAGTCTGATGTACTTTCCACT
GGGCCAGCCAGCAACAAGTGGACGAAAAGGAATGCCCCTGCCCAGTGGAGGCGGAAAGAT
CGGCAGAAGCAGCACACAGAACACCTGCGTTTAGATAATGACCAGAGGGAGAAGTACATC
CAGGAAGCCAGGACTATGGGCAGCACTATCCGCCAGCCCAAACTGTCCAACCTCTCTCCA
TCAGTGATTGCCCAGACCAATTGGAAGTTTGTAGAGGGCCTGCTGAAGGAATGCCGCAAT
AAGACCAAGAGGATGCTGGTGGAAAAGATGGGCCGAGAAGCTGTGGAGCTAGGGCATGGG
GAGGTGAACATCACAGGGGTGGAAGAGAACACCCTGATTGCCAGCCTTTGTGATCTCCTG
GAAAGGATCTGGAGTCATGGACTACAAGTGAAACAGGGGAAATCAGCCTTATGGTCCCAC
CTGTTACATTATCAGGACAACCGGCAGAGAAAACTCACATCAGGAAGCCTCAGTACCTCA
GGAATACTTCTTGATTCAGAACGTAGGAAGTCTGATGCCAGCTCACTCATGCCTCCCCTG
AGGATCTCCCTGATTCAGGATATGAGGCACATCCAGAACATCGGGGAAATCAAGACTGAT
GTGGGAAAGGCCAGAGCATGGGTGCGACTGTCCATGGAAAAAAAGTTACTTTCCAGACAC
CTGAAGCAGCTCCTCTCAGACCATGAGCTCACCAAAAAGTTATATAAGCGCTATGCCTTC
CTGCGCTGTGATGACGAGAAGGAGCAGTTCCTCTATCACCTCCTGTCTTTCAATGCCGTC
GATTACTTTTGCTTCACCAATGTCTTCACAACTATCCTGATCCCGTACCACATTCTGATC
GTACCAAGCAAGAAGCTGGGGGGCTCCATGTTCACTGCCAACCCATGGATCTGTATATCA
GGAGAATTGGGTGAGACACAGATCATGCAGATTCCCAGGAATGTGCTAGAGATGACCTTC
GAGTGCCAGAACTTGGGGAAGCTTACTACTGTCCAGATTGGCCATGATAACTCTGGGCTG
TATGCCAAATGGCTGGTGGAGTATGTGATGGTCAGGAATGAGATCACAGGACATACCTAC
AAGTTCCCGTGTGGCCGGTGGTTAGGGAAGGGCATGGATGATGGAAGCCTGGAGCGGATC
CTAGTTGGGGAGCTGCTCACATCCCAGCCTGAGGTGGATGAGAGGCCATGCCGGACCCCG
CCGCTGCAGCAGTCCCCCAGTGTCATCCGGAGGCTTGTTACCATCTCACCCAACAACAAG
CCCAAGCTGAACACTGGGCAGATCCAGGAGTCCATCGGGGAGGCAGTCAATGGCATTGTG
AAGCACTTCCATAAGCCTGAGAAAGAGCGAGGCAGTCTGACGCTGTTGCTCTGTGGAGAG
TGTGGCCTTGTCTCGGCCTTGGAACAGGCTTTCCAGCATGGATTTAAATCGCCCCGGCTC
TTCAAAAATGTCTTCATTTGGGATTTCCTGGAAAAAGCACAAACCTATTATGAGACATTA
GAGAAGAATGAAGTAGTCCCTGAGGAAAACTGGCATACAAGAGCCCGGAACTTCTGCCGA
TTTGTCACTGCAATCAACAATACTCCCCGGAACATCGGCAAGGATGGCAAGTTTCAGATG
CTGGTGTGCTTGGGAGCCAGAGATCACCTCCTACACCACTGGATTGCCCTGCTGGCTGAC
TGCCCCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAAGACCATACACTTGTC
AATTCCTTGATTCGTGTGCTGCAGACATTGCAGGAGTTCAACATCACGCTGGAGACGTCC
CTTGTCAAGGGCATCGACATCTGA
Protein Properties
Number of Residues 1287
Molecular Weight 147093.3
Theoretical pI 6.68
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>DENN domain-containing protein 5A
MSGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQASKARDGASPFISSTTE
GENFEQTPLRRTFKSKVLARYPENVEWNPFDQDAVGMLCMPKGLAFKTQADPREPQFHAF
IITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPPADDRDQSSMEDG
EDTPVTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLQQLHQAVTSPQPPPLPL
ESYIYNVLYEVPLPPPGRSLKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQ
LFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYL
MGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGI
PPEGNLHCSESASKLKRLRASELVSDKRNGNIAGSPLHSYELLKENETIARLQALVKRTG
VSLEKLEVREDPSSNKDLKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQPSQ
DKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPV
LRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIELRLAKIDHTAIHPHLLDMKI
GQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREKYI
QEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHG
EVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSLSTS
GILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRH
LKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILI
VPSKKLGGSMFTANPWICISGELGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGL
YAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGELLTSQPEVDERPCRTP
PLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGE
CGLVSALEQAFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEKNEVVPEENWHTRARNFCR
FVTAINNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVALIKDHTLV
NSLIRVLQTLQEFNITLETSLVKGIDI
GenBank ID Protein 44889475
UniProtKB/Swiss-Prot ID Q6IQ26
UniProtKB/Swiss-Prot Entry Name DEN5A_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_015213.2
GeneCard ID DENND5A
GenAtlas ID DENND5A
HGNC ID HGNC:19344
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  4. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
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