Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP08518
Secondary Accession Numbers
  • 14230
Name Ran-binding protein 3
Synonyms
  1. RanBP3
Gene Name RANBP3
Protein Type Unknown
Biological Properties
General Function Involved in intracellular transport
Specific Function Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner
Pathways Not Available
Reactions Not Available
GO Classification
Process
establishment of localization
transport
intracellular transport
Cellular Location
  1. Nucleus
  2. Cytoplasm
Gene Properties
Chromosome Location Chromosome:1
Locus 19p13.3
SNPs RANBP3
Gene Sequence
>1704 bp
ATGGCGGACCTGGCGAACGAAGAAAAGCCTGCCATTGCTCCGCCCGTCTTTGTGTTTCAG
AAGGATAAAGGACAAAAGTCCCCTGCAGAGCAAAAAAACTTGTCGGATTCGGGAGAGGAG
CCTCGGGGGGAGGCTGAGGCCCCCCACCATGGCACGGGTCACCCCGAGTCAGCTGGCGAG
CATGCCCTAGAACCTCCTGCCCCTGCTGGCGCCTCAGCCAGCACTCCTCCGCCTCCCGCT
CCTGAAGCCCAGCTTCCTCCTTTTCCGCGAGAACTGGCAGGGAGGTCAGCTGGCGGCTCC
AGTCCTGAAGGCGGAGAAGATTCTGACAGAGAAGATGGAAATTACTGCCCTCCTGTCAAG
CGAGAAAGAACATCCTCTTTAACCCAGTTCCCACCCTCACAGTCAGAGGAAAGGAGCAGT
GGCTTCCGGTTGAAGCCACCAACGCTGATCCACGGCCAAGCCCCCAGCGCAGGTCTGCCA
AGCCAGAAGCCCAAGGAGCAGCAGCGGAGCGTGCTTCGCCCGGCAGTGTTACAAGCTCCG
CAGCCAAAGGCGCTGTCCCAGACTGTCCCCAGCAGTGGCACCAACGGGGTCAGCCTCCCA
GCAGACTGCACGGGGGCAGTGCCCGCAGCATCCCCTGACACTGCTGCATGGAGAAGTCCT
TCCGAAGCTGCCGATGAGGTGTGTGCACTTGAGGAGAAAGAGCCCCAGAAAAATGAGTCC
AGCAATGCCTCTGAAGAGGAAGCCTGTGAGAAAAAAGACCCCGCCACACAGCAAGCCTTT
GTATTTGGGCAGAACTTGAGGGACAGAGTTAAGCTGATAAATGAGAGCGTGGACGAAGCC
GACATGGAGAATGCTGGACACCCCAGCGCAGACACGCCAACCGCAACGAACTATTTCCTC
CAGTATATCAGTTCCAGTTTAGAGAACTCAACCAATAGTGCCGACGCCTCCAGCAACAAA
TTTGTATTTGGCCAGAACATGAGCGAGCGAGTTTTGAGCCCCCCAAAATTAAACGAGGTC
AGTTCAGATGCCAACAGGGAAAATGCAGCTGCCGAGTCAGGGTCTGAGTCCTCGTCCCAG
GAGGCCACCCCTGAGAAAGAGTCCCTGGCTGAGTCGGCAGCCGCCTACACCAAGGCAACA
GCGCGGAAGTGTTTGTTGGAAAAAGTGGAAGTCATCACCGGGGAGGAGGCGGAGAGCAAT
GTGTTACAGATGCAGTGCAAGCTGTTTGTCTTTGACAAGACCTCACAGTCCTGGGTGGAG
AGAGGCCGGGGGCTGCTCAGACTCAATGACATGGCGTCCACCGATGACGGCACACTACAG
TCCCGACTAGTGATGCGGACCCAGGGGAGCCTGCGACTGATCCTCAACACCAAGCTGTGG
GCCCAGATGCAGATCGACAAGGCCAGCGAGAAGAGCATTCGCATCACAGCCATGGACACC
GAGGACCAGGGCGTGAAGGTCTTCCTGATCTCGGCCAGCTCCAAGGACACAGGTCAGTTG
TATGCAGCCCTGCACCACCGCATCCTGGCCCTGCGCAGCCGCGTGGAGCAGGAGCAGGAG
GCCAAGATGCCCGCGCCTGAGCCTGGGGCAGCCCCATCCAACGAGGAGGACGACAGCGAC
GATGACGATGTCCTGGCTCCTTCAGGGGCCACCGCAGCTGGTGCTGGTGACGAAGGGGAC
GGGCAGACGACCGGGAGCACATAG
Protein Properties
Number of Residues 567
Molecular Weight 60209.3
Theoretical pI 4.42
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Ran-binding protein 3
MADLANEEKPAIAPPVFVFQKDKGQKSPAEQKNLSDSGEEPRGEAEAPHHGTGHPESAGE
HALEPPAPAGASASTPPPPAPEAQLPPFPRELAGRSAGGSSPEGGEDSDREDGNYCPPVK
RERTSSLTQFPPSQSEERSSGFRLKPPTLIHGQAPSAGLPSQKPKEQQRSVLRPAVLQAP
QPKALSQTVPSSGTNGVSLPADCTGAVPAASPDTAAWRSPSEAADEVCALEEKEPQKNES
SNASEEEACEKKDPATQQAFVFGQNLRDRVKLINESVDEADMENAGHPSADTPTATNYFL
QYISSSLENSTNSADASSNKFVFGQNMSERVLSPPKLNEVSSDANRENAAAESGSESSSQ
EATPEKESLAESAAAYTKATARKCLLEKVEVITGEEAESNVLQMQCKLFVFDKTSQSWVE
RGRGLLRLNDMASTDDGTLQSRLVMRTQGSLRLILNTKLWAQMQIDKASEKSIRITAMDT
EDQGVKVFLISASSKDTGQLYAALHHRILALRSRVEQEQEAKMPAPEPGAAPSNEEDDSD
DDDVLAPSGATAAGAGDEGDGQTTGST
GenBank ID Protein 6466466
UniProtKB/Swiss-Prot ID Q9H6Z4
UniProtKB/Swiss-Prot Entry Name RANB3_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_007322.2
GeneCard ID RANBP3
GenAtlas ID RANBP3
HGNC ID HGNC:9850
References
General References
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