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Showing Protein GTPase ERas (HMDBP08522)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP08522
Secondary Accession Numbers
  • 14234
Name GTPase ERas
Synonyms
  1. E-Ras
  2. Embryonic stem cell-expressed Ras
Gene Name ERAS
Protein Type Unknown
Biological Properties
General Function Involved in GTP binding
Specific Function Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
intracellular
Function
purine nucleotide binding
binding
nucleotide binding
catalytic activity
hydrolase activity
guanyl nucleotide binding
guanyl ribonucleotide binding
gtp binding
gtpase activity
nucleoside-triphosphatase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity
Process
biological regulation
regulation of biological process
regulation of cellular process
signal transduction
intracellular signal transduction
small gtpase mediated signal transduction
Cellular Location
  1. Cell membrane
  2. Lipid-anchor
  3. Cytoplasmic side
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs ERAS
Gene Sequence 
>702 bp
ATGGAGCTGCCAACAAAGCCTGGCACCTTCGACCTGGGCCTGGCCACATGGAGCCCTTCC
TTCCAGGGGGAAACCCACCGGGCTCAGGCACGCCGCAGGGATGTTGGCAGGCAGCTGCCT
GAGTACAAGGCTGTGGTGGTGGGCGCCAGTGGCGTGGGCAAGAGTGCGCTGACCATCCAG
CTGAACCACCAGTGCTTCGTGGAGGACCACGACCCCACCATCCAGGATTCCTACTGGAAG
GAGTTGACCCTGGACAGTGGGGACTGCATTCTGAATGTGCTGGACACAGCAGGGCAGGCC
ATCCATAGGGCCCTGCGTGACCAGTGCCTGGCTGTCTGTGATGGTGTGCTGGGCGTCTTC
GCTCTCGATGACCCCTCGTCTCTGATCCAGCTGCAGCAGATATGGGCCACCTGGGGCCCT
CACCCCGCCCAGCCCCTTGTCCTCGTGGGCAACAAGTGTGACCTTGTGACCACTGCTGGA
GATGCTCATGCCGCTGCTGCAGCCCTCGCACACAGCTGGGGGGCCCACTTCGTGGAGACC
TCGGCCAAAACACGGCAAGGCGTGGAGGAGGCCTTTTCCCTGCTGGTCCATGAGATCCAG
AGGGTCCAGGAGGCCATGGCGAAGGAGCCCATGGCAAGGTCCTGTAGGGAGAAGACCCGG
CACCAGAAGGCCACCTGCCACTGTGGCTGCTCTGTGGCCTGA
Protein Properties
Number of Residues 233
Molecular Weight 25286.5
Theoretical pI 6.57
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence 
>GTPase ERas
MELPTKPGTFDLGLATWSPSFQGETHRAQARRRDVGRQLPEYKAVVVGASGVGKSALTIQ
LNHQCFVEDHDPTIQDSYWKELTLDSGDCILNVLDTAGQAIHRALRDQCLAVCDGVLGVF
ALDDPSSLIQLQQIWATWGPHPAQPLVLVGNKCDLVTTAGDAHAAAAALAHSWGAHFVET
SAKTRQGVEEAFSLLVHEIQRVQEAMAKEPMARSCREKTRHQKATCHCGCSVA
GenBank ID Protein 31158278
UniProtKB/Swiss-Prot ID Q7Z444
UniProtKB/Swiss-Prot Entry Name RASE_HUMAN
PDB IDs Not Available
GenBank Gene ID AB093575
GeneCard ID ERAS
GenAtlas ID ERAS
HGNC ID HGNC:5174
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Takahashi K, Mitsui K, Yamanaka S: Role of ERas in promoting tumour-like properties in mouse embryonic stem cells. Nature. 2003 May 29;423(6939):541-5. [PubMed:12774123 ]