Hmdb loader
Identification
HMDB Protein ID HMDBP08525
Secondary Accession Numbers
  • 14237
Name Ras association domain-containing protein 4
Synonyms Not Available
Gene Name RASSF4
Protein Type Unknown
Biological Properties
General Function Involved in signal transduction
Specific Function Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
protein binding
Process
biological regulation
regulation of biological process
regulation of cellular process
signal transduction
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:1
Locus 10q11.21
SNPs RASSF4
Gene Sequence
>966 bp
ATGAAGGAAGACTGTCTGCCGAGTTCTCACGTGCCCATCAGTGACAGCAAGTCCATTCAG
AAGTCGGAGCTCTTAGGCCTGCTGAAAACCTACAACTGCTACCATGAGGGCAAGAGCTTC
CAGCTGAGACACCGTGAGGAAGAAGGGACTCTGATCATCGAGGGGCTCCTCAACATTGCC
TGGGGGCTGAGGCGGCCCATCCGGCTGCAGATGCAGGATGACCGGGAGCAGGTGCACCTC
CCCTCCACCTCATGGATGCCCAGACGGCCTAGCTGCCCTCTAAAGGAGCCATCGCCCCAG
AACGGGAACATCACAGCCAAGGGGCCAAGCATTCAGCCAGTGCACAAGGCTGAGAGTTCC
ACAGACAGCTCGGGGCCCCTGGAGGAGGCAGAGGAGGCCCCCCAGCTGATGCGGACCAAG
AGCGACGCCAGTTGCATGAGCCAGAGGAGGCCCAAGTGCCGCGCCCCCGGTGAGGCCCAG
CGCATCCGGCGACACCGGTTCTCTATCAACGGCCACTTCTACAATCATAAGACCTCCGTG
TTTACTCCAGCCTATGGATCCGTGACCAATGTGAGGGTCAACAGCACCATGACAACCCTG
CAGGTGCTCACCCTGCTGCTGAACAAATTTAGGGTGGAAGATGGCCCCAGTGAGTTCGCA
CTCTACATCGTTCACGAGTCTGGGGAGCGGACAAAATTAAAAGACTGCGAGTACCCGCTG
ATTTCCAGAATCCTGCATGGGCCATGTGAGAAGATCGCCAGGATCTTCCTGATGGAAGCT
GACTTGGGCGTGGAAGTCCCCCATGAAGTCGCTCAGTACATTAAGTTTGAAATGCCGGTG
CTGGACAGTTTTGTTGAAAAATTAAAAGAAGAGGAAGAAAGAGAAATAATCAAACTGACC
ATGAAGTTCCAAGCCCTGCGTCTGACGATGCTGCAGCGCCTGGAGCAGCTGGTGGAGGCC
AAGTAA
Protein Properties
Number of Residues 321
Molecular Weight 36747.9
Theoretical pI 7.85
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Ras association domain-containing protein 4
MKEDCLPSSHVPISDSKSIQKSELLGLLKTYNCYHEGKSFQLRHREEEGTLIIEGLLNIA
WGLRRPIRLQMQDDREQVHLPSTSWMPRRPSCPLKEPSPQNGNITAQGPSIQPVHKAESS
TDSSGPLEEAEEAPQLMRTKSDASCMSQRRPKCRAPGEAQRIRRHRFSINGHFYNHKTSV
FTPAYGSVTNVRVNSTMTTLQVLTLLLNKFRVEDGPSEFALYIVHESGERTKLKDCEYPL
ISRILHGPCEKIARIFLMEADLGVEVPHEVAQYIKFEMPVLDSFVEKLKEEEEREIIKLT
MKFQALRLTMLQRLEQLVEAK
GenBank ID Protein 12005908
UniProtKB/Swiss-Prot ID Q9H2L5
UniProtKB/Swiss-Prot Entry Name RASF4_HUMAN
PDB IDs Not Available
GenBank Gene ID AF260335
GeneCard ID RASSF4
GenAtlas ID RASSF4
HGNC ID HGNC:20793
References
General References
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  2. Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J: The DNA sequence and comparative analysis of human chromosome 10. Nature. 2004 May 27;429(6990):375-81. [PubMed:15164054 ]
  3. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  4. Eckfeld K, Hesson L, Vos MD, Bieche I, Latif F, Clark GJ: RASSF4/AD037 is a potential ras effector/tumor suppressor of the RASSF family. Cancer Res. 2004 Dec 1;64(23):8688-93. [PubMed:15574778 ]