Hmdb loader
Identification
HMDB Protein ID HMDBP08530
Secondary Accession Numbers
  • 14242
Name Rab3 GTPase-activating protein non-catalytic subunit
Synonyms
  1. RGAP-iso
  2. Rab3 GTPase-activating protein 150 kDa subunit
  3. Rab3-GAP p150
  4. Rab3-GAP regulatory subunit
  5. Rab3-GAP150
Gene Name RAB3GAP2
Protein Type Unknown
Biological Properties
General Function Involved in GTPase activator activity
Specific Function Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Cytoplasm
Gene Properties
Chromosome Location Chromosome:1
Locus 1q41
SNPs RAB3GAP2
Gene Sequence
>4182 bp
ATGGCCTGCTCCATTGTCCAGTTCTGCTACTTCCAGGACCTCCAGGCCGCCCGGGACTTC
CTCTTTCCTCACCTGCGGGAGGAGATCCTCAGCGGCGCCTTGCGGAGGGACCCCAGTAAA
TCAACAGACTGGGAAGATGATGGTTGGGGAGCATGGGAAGAAAATGAACCACAAGAACCT
GAAGAAGAAGGAAATACTTGCAAAACACAAAAAACTTCCTGGCTCCAAGATTGTGTTTTA
TCCTTATCTCCAACCAATGATCTTATGGTGATAGCTCGAGAGCAAAAAGCTGTATTTCTA
GTGCCAAAATGGAAATATAGTGATAAAGGAAAGGAAGAAATGCAATTTGCTGTTGGCTGG
AGTGGTTCCTTAAATGTCGAAGAAGGGGAATGTGTAACCAGTGCTCTATGTATCCCACTA
GCAAGCCAAAAGAGGAGTTCCACTGGGCGTCCTGACTGGACCTGCATTGTGGTGGGTTTT
ACTTCAGGTTATGTACGCTTCTACACTGAGAATGGTGTGCTCTTGCTTGCACAGCTTTTG
AATGAGGACCCAGTACTTCAACTTAAATGCAGAACCTATGAAATACCACGACATCCCGGC
GTGACTGAGCAGAATGAAGAGTTGAGTATCTTATATCCAGCTGCCATTGTGACTATTGAT
GGATTTAGCCTTTTTCAATCTCTTCGTGCTTGTCGAAATCAGGTAGCAAAAGCTGCAGCA
TCAGGCAACGAGAACATACAACCACCACCATTAGCTTATAAGAAATGGGGTCTACAAGAT
ATTGACACTATTATTGATCATGCTAGTGTTGGTATTATGACTCTGTCCCCCTTTGATCAA
ATGAAGACTGCCTCCAATATAGGTGGATTTAATGCAGCAATTAAAAATAGTCCACCTGCC
ATGTCTCAGTATATCACTGTAGGGTCCAATCCATTTACTGGCTTCTTCTATGCTTTAGAG
GGAAGCACACAACCATTATTATCCCATGTTGCACTAGCAGTTGCAAGTAAACTCACTTCT
GCTTTATTTAATGCTGCCAGTGGTTGGCTTGGTTGGAAAAGTAAGCACGAAGAAGAAGCT
GTCCAAAAGCAAAAGCCGAAGGTTGAGCCAGCTACCCCATTAGCTGTAAGATTTGGACTT
CCAGATTCTAGACGCCATGGTGAAAGCATATGTCTGTCTCCATGTAACACACTGGCAGCA
GTAACAGATGATTTCGGCAGAGTTATTTTATTGGATGTAGCTAGAGGAATTGCAATACGC
ATGTGGAAAGGGTACCGCGACGCACAAATTGGATGGATTCAAACTGTAGAGGACCTCCAT
GAAAGAGTGCCAGAAAAGGCAGATTTTTCCCCCTTTGGAAATTCTCAGGGTCCAAGTCGA
GTAGCTCAATTCCTTGTGATCTATGCGCCAAGAAGGGGAATTTTAGAAGTGTGGAGCACA
CAGCAGGGACCTAGAGTAGGAGCTTTCAATGTGGGGAAGCACTGCAGGCTGCTGTATCCT
GGCTATAAAATAATGGGTTTAAATAATGTTACCAGTCAGAGTTGGCAGCCACAGACTTAT
CAGATCTGTCTGGTTGATCCAGTGTCTGGAAGTGTGAAAACAGTGAACGTTCCCTTCCAT
TTAGCACTGAGTGATAAGAAGAGTGAACGAGCCAAGGATATGCACCTAGTGAAGAAACTA
GCAGCCTTACTGAAAACAAAATCTCCCAATCTTGATTTGGTTGAAACAGAAATAAAGGAA
TTAATTCTTGATATTAAATACCCTGCAACCAAAAAACAAGCTTTGGAAAGCATTTTGGCA
AGTGAACGTTTACCATTTTCTTGCCTTAGAAACATCACTCAGACTTTAATGGACACTTTA
AAAAGTCAAGAACTTGAGTCTGTTGATGAAGGATTGCTACAGTTTTGTGCCAATAAACTA
AAACTGCTGCAACTCTATGAGTCTGTCAGTCAATTAAATTCCCTTGATTTTCATTTAGAC
ACACCATTCTCTGATAATGACTTGGCTCTGTTACTAAGGCTTGATGAAAAAGAACTGCTT
AAGCTCCAGGCATTACTAGAGAAATATAAGCAAGAGAACACCAGGACAAATGTTCGATTT
TCTGATGATAAAGATGGTGTGTTGCCTGTAAAAACATTCTTGGAATATTTAGAATATGAA
AAGGATGTGCTCAACATAAAGAAAATAAGTGAAGAGGAATATGTGGCTTTAGGTAGTTTC
TTTTTTTGGAAGTGTTTGCATGGAGAAAGCTCCACTGAGGATATGTGTCACACTTTGGAG
TCGGCTGGTCTTAGCCCTCAGCTGTTGTTGTCTCTGCTCCTGAGTGTTTGGCTTTCAAAG
GAAAAGGATATTTTGGATAAACCACAGTCAATCTGCTGTCTTCATACCATGCTGTCCCTC
CTGAGCAAGATGAAAGTGGCCATCGATGAGACCTGGGATTCTCAGTCTGTGTCCCCATGG
TGGCAGCAGATGCGCACAGCCTGTATTCAGTCTGAGAACAATGGAGCCGCTCTGTTGTCT
GCGCATGTTGGGCATTCTGTTGCTGCACAGATATCAAACAACATGACAGAGAAAAAATTT
TCCCAAACAGTTTTGGGTGCTGATTCAGAGGCCCTCACTGATTCCTGGGAGGCACTTTCT
CTTGACACTGAGTACTGGAAACTCCTTCTGAAACAGCTGGAGGATTGTCTCATACTTCAG
ACTCTGCTTCACAGCAAAGGGAACACTCAGACCTCCAAAGTGTCATCACTGCAGGCTGAG
CCACTTCCAAGGCTTTCTGTTAAAAAGTTATTAGAAGGAGGAAAAGGTGGCATTGCAGAC
AGTGTAGCCAAGTGGATATTTAAACAGGACTTCAGCCCTGAAGTATTAAAACTGGCTAAT
GAAGAAAGAGATGCAGAAAACCCAGATGAACCCAAAGAAGGTGTTAACAGAAGTTTCCTT
GAGGTATCAGAGATGGAGATGGACTTAGGAGCCATACCAGACTTACTGCATTTAGCCTAT
GAGCAGTTTCCTTGTAGCCTTGAGCTCGATGTCTTGCATGCACATTGCTGCTGGGAGTAC
GTTGTTCAGTGGAATAAAGATCCAGAGGAAGCACGTTTTTTTGTTAGGTCAATAGAACAC
TTGAAGCAAATATTTAATGCACATGTTCAAAATGGCATTGCACTGATGATGTGGAATACG
TTCTTAGTTAAAAGATTTTCTGCTGCTACATACTTAATGGATAAGGTTGGAAAATCACCA
AAAGATAGGTTATGCCGAAGGGATGTGGGAATGAGTGACACAGCAATGACATCTTTCCTC
GGCTCCTGTTTGGATCTTCTTCAGATCTTAATGGAGGCAGATGTTAGCAGGGATGAAATA
CAGGTGCCTGTGCTGGATACTGAGGATGCGTGGCTCTCCGTGGAAGGACCAATCTCCATA
GTGGAACTGGCCCTTGAACAGAAGCACATCCACTACCCACTGGTGGAGCACCACTCCATC
CTGTGCTCCATCTTGTATGCAGTCATGAGGTTTTCTCTGAAGACCGTGAAGCCACTTTCA
CTTTTTGACAGTAAGGGAAAAAATGCATTTTTCAAAGACCTAACTTCAATTCAGTTATTA
CCTAGTGGGGAAATGGATCCAAATTTTATTTCTGTACGACAACAGTTCTTATTGAAAGTT
GTCAGTGCAGCTGTCCAGGCCCAACATTCAGCCACAAAGGTCAAAGATCCCACAGAAGAG
GCCACACCCACTCCTTTTGGGAAAGACCAAGATTGGCCAGCTCTAGCTGTGGATTTAGCC
CATCACCTTCAAGTTAGTGAAGATGTTGTTAGAAGGCATTATGTGGGGGAACTATACAAC
TATGGAGTTGACCACTTAGGAGAAGAGGCCATTCTACAGGTTCATGACAAAGAGGTCCTT
GCCTCTCAGCTGCTGGTGCTCACGGGGCAAAGGCTGGCTCATGCGCTTCTCCACACCCAG
ACAAAAGAAGGAATGGAGCTGCTTGCCAGACTTCCACCCACACTGTGTACTTGGCTGAAA
GCAATGGACCCCCAGGACCTTCAAAACACTGAAGTGCCAATTGCAACAACAGCTAAACTA
GTAAATAAAGTAATTGAGCTTTTACCAGAAAAACATGGGCAATATGGTCTAGCCTTACAC
CTCATTGAAGCTGTGGAAGCCATATCTCTTCCTTCTTTATGA
Protein Properties
Number of Residues 1393
Molecular Weight 155983.3
Theoretical pI 5.34
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Rab3 GTPase-activating protein non-catalytic subunit
MACSIVQFCYFQDLQAARDFLFPHLREEILSGALRRDPSKSTDWEDDGWGAWEENEPQEP
EEEGNTCKTQKTSWLQDCVLSLSPTNDLMVIAREQKAVFLVPKWKYSDKGKEEMQFAVGW
SGSLNVEEGECVTSALCIPLASQKRSSTGRPDWTCIVVGFTSGYVRFYTENGVLLLAQLL
NEDPVLQLKCRTYEIPRHPGVTEQNEELSILYPAAIVTIDGFSLFQSLRACRNQVAKAAA
SGNENIQPPPLAYKKWGLQDIDTIIDHASVGIMTLSPFDQMKTASNIGGFNAAIKNSPPA
MSQYITVGSNPFTGFFYALEGSTQPLLSHVALAVASKLTSALFNAASGWLGWKSKHEEEA
VQKQKPKVEPATPLAVRFGLPDSRRHGESICLSPCNTLAAVTDDFGRVILLDVARGIAIR
MWKGYRDAQIGWIQTVEDLHERVPEKADFSPFGNSQGPSRVAQFLVIYAPRRGILEVWST
QQGPRVGAFNVGKHCRLLYPGYKIMGLNNVTSQSWQPQTYQICLVDPVSGSVKTVNVPFH
LALSDKKSERAKDMHLVKKLAALLKTKSPNLDLVETEIKELILDIKYPATKKQALESILA
SERLPFSCLRNITQTLMDTLKSQELESVDEGLLQFCANKLKLLQLYESVSQLNSLDFHLD
TPFSDNDLALLLRLDEKELLKLQALLEKYKQENTRTNVRFSDDKDGVLPVKTFLEYLEYE
KDVLNIKKISEEEYVALGSFFFWKCLHGESSTEDMCHTLESAGLSPQLLLSLLLSVWLSK
EKDILDKPQSICCLHTMLSLLSKMKVAIDETWDSQSVSPWWQQMRTACIQSENNGAALLS
AHVGHSVAAQISNNMTEKKFSQTVLGADSEALTDSWEALSLDTEYWKLLLKQLEDCLILQ
TLLHSKGNTQTSKVSSLQAEPLPRLSVKKLLEGGKGGIADSVAKWIFKQDFSPEVLKLAN
EERDAENPDEPKEGVNRSFLEVSEMEMDLGAIPDLLHLAYEQFPCSLELDVLHAHCCWEY
VVQWNKDPEEARFFVRSIEHLKQIFNAHVQNGIALMMWNTFLVKRFSAATYLMDKVGKSP
KDRLCRRDVGMSDTAMTSFLGSCLDLLQILMEADVSRDEIQVPVLDTEDAWLSVEGPISI
VELALEQKHIHYPLVEHHSILCSILYAVMRFSLKTVKPLSLFDSKGKNAFFKDLTSIQLL
PSGEMDPNFISVRQQFLLKVVSAAVQAQHSATKVKDPTEEATPTPFGKDQDWPALAVDLA
HHLQVSEDVVRRHYVGELYNYGVDHLGEEAILQVHDKEVLASQLLVLTGQRLAHALLHTQ
TKEGMELLARLPPTLCTWLKAMDPQDLQNTEVPIATTAKLVNKVIELLPEKHGQYGLALH
LIEAVEAISLPSL
GenBank ID Protein 20521672
UniProtKB/Swiss-Prot ID Q9H2M9
UniProtKB/Swiss-Prot Entry Name RBGPR_HUMAN
PDB IDs Not Available
GenBank Gene ID AB020646
GeneCard ID RAB3GAP2
GenAtlas ID RAB3GAP2
HGNC ID HGNC:17168
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
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  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
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