Hmdb loader
Identification
HMDB Protein ID HMDBP08541
Secondary Accession Numbers
  • 14254
Name Rab11 family-interacting protein 4
Synonyms
  1. Arfophilin-2
  2. FIP4-Rab11
  3. Rab11-FIP4
Gene Name RAB11FIP4
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6
Pathways Not Available
Reactions Not Available
GO Classification
Component
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
establishment of localization
transport
protein transport
Cellular Location
  1. Peripheral membrane protein
  2. Cleavage furrow
  3. Midbody
  4. Recycling endosome membrane
Gene Properties
Chromosome Location Chromosome:1
Locus 17q11.2
SNPs RAB11FIP4
Gene Sequence
>1914 bp
ATGGCGGGCGGCGCGGGCTGGTCGGGCGCCCCCGCGGCTCTGCTGCGCTCCGTGCGCCGC
CTGCGCGAGGTGTTCGAGGTGTGCGGCCGCGACCCCGACGGCTTCCTGCGCGTGGAGCGC
GTCGCGGCGCTCGGACTGCGCTTCGGCCAGGGCGAGGAGGTGGAAAAACTTGTGAAATAT
TTGGATCCCAACGACCTGGGGAGAATCAACTTCAAGGACTTTTGCCGGGGGGTGTTCGCC
ATGAAAGGGTGCGAGGAGCTGCTGAAGGATGTGCTGTCGGTGGAGAGCGCGGGGACGCTG
CCGTGCGCGCCAGAGATCCCAGACTGCGTGGAGCAGGGCAGCGAGGTCACAGGCCCCACC
TTTGCTGATGGCGAGCTCATCCCCAGGGAACCCGGCTTTTTTCCCGAGGACGAGGAGGAG
GCTATGACGCTGGCGCCACCTGAGGGCCCCCAGGAGTTGTACACAGACAGCCCCATGGAG
AGCACTCAGAGCCTGGAGGGGTCTGTCGGGAGTCCTGCCGAGAAGGACGGGGGACTTGGG
GGCCTGTTTCTGCCAGAAGACAAGTCCCTGGTCCACACTCCATCCATGACGACCTCAGAC
CTTTCTACACACTCCACCACCTCGCTCATCAGCAATGAGGAGCAGTTTGAAGACTATGGG
GAGGGTGACGATGTGGACTGTGCCCCCAGCAGCCCTTGCCCCGATGATGAGACCAGGACC
AACGTCTACTCGGACCTGGGGTCTTCGGTGTCTTCCAGTGCGGGGCAGACGCCTAGGAAA
ATGCGGCACGTGTACAACAGCGAATTGCTAGATGTTTACTGCTCTCAATGCTGCAAGAAA
ATCAACCTGCTCAATGACTTGGAAGCCCGACTGAAAAACCTGAAGGCCAACAGCCCCAAC
CGAAAGATCTCCAGCACGGCCTTTGGACGGCAGCTCATGCACAGCAGCAACTTCAGCAGC
AGCAATGGCAGCACCGAAGACCTGTTCCGGGACAGCATTGACTCTTGCGACAATGACATC
ACAGAGAAGGTAAGCTTCCTGGAAAAGAAGGTGACAGAGCTGGAGAATGACAGCCTGACC
AATGGGGACCTGAAGAGCAAGCTGAAGCAAGAGAACACACAGCTGGTGCACAGGGTGCAT
GAGCTGGAGGAGATGGTGAAGGATCAGGAGACCACGGCCGAGCAGGCTCTGGAGGAGGAG
GCGCGGCGCCACCGCGAGGCCTACGGCAAGCTGGAGAGGGAGAAGGCTACCGAGGTGGAG
CTGCTCAATGCCAGGGTGCAGCAGTTGGAGGAAGAAAATACAGAGCTTAGAACAACAGTG
ACTCGGCTCAAGTCTCAAACAGAGAAACTGGATGAGGAGCGGCAGCGCATGTCTGACCGT
CTGGAGGACACCAGCCTGCGGCTCAAAGATGAGATGGACCTGTACAAGCGCATGATGGAC
AAGCTGCGACAGAACCGCCTTGAGTTCCAGAAGGAGCGGGAGGCGACGCAGGAGCTCATC
GAGGACTTGCGGAAGGAGCTGGAGCACCTGCAGATGTACAAGCTGGACTGCGAGCGGCCA
GGCAGGGGCCGCAGTGCCTCCTCTGGCCTAGGCGAGTTCAATGCCAGGGCCCGCGAGGTG
GAGCTCGAGCACGAGGTCAAGCGGCTCAAGCAGGAGAATTATAAGCTGCGGGATCAGAAC
GACGACTTGAATGGGCAGATTTTGAGCCTCAGCCTCTACGAAGCAAAAAACCTCTTTGCT
GCCCAGACTAAAGCCCAGTCTCTGGCTGCGGAGATAGACACCGCCTCGCGCGATGAGCTA
ATGGAAGCCCTGAAGGAGCAGGAGGAGATCAACTTCCGGCTGAGGCAGTACATGGACAAG
ATTATCCTCGCCATCCTGGACCACAATCCCTCCATCCTCGAGATCAAACACTAA
Protein Properties
Number of Residues 637
Molecular Weight 71927.5
Theoretical pI 4.5
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Rab11 family-interacting protein 4
MAGGAGWSGAPAALLRSVRRLREVFEVCGRDPDGFLRVERVAALGLRFGQGEEVEKLVKY
LDPNDLGRINFKDFCRGVFAMKGCEELLKDVLSVESAGTLPCAPEIPDCVEQGSEVTGPT
FADGELIPREPGFFPEDEEEAMTLAPPEGPQELYTDSPMESTQSLEGSVGSPAEKDGGLG
GLFLPEDKSLVHTPSMTTSDLSTHSTTSLISNEEQFEDYGEGDDVDCAPSSPCPDDETRT
NVYSDLGSSVSSSAGQTPRKMRHVYNSELLDVYCSQCCKKINLLNDLEARLKNLKANSPN
RKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLT
NGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGKLEREKATEVE
LLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMD
KLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREV
ELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDEL
MEALKEQEEINFRLRQYMDKIILAILDHNPSILEIKH
GenBank ID Protein 28195388
UniProtKB/Swiss-Prot ID Q86YS3
UniProtKB/Swiss-Prot Entry Name RFIP4_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_032932.3
GeneCard ID RAB11FIP4
GenAtlas ID RAB11FIP4
HGNC ID HGNC:30267
References
General References
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  3. Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O: Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 2001 Apr 27;8(2):85-95. [PubMed:11347906 ]
  4. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  5. Fielding AB, Schonteich E, Matheson J, Wilson G, Yu X, Hickson GR, Srivastava S, Baldwin SA, Prekeris R, Gould GW: Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. EMBO J. 2005 Oct 5;24(19):3389-99. Epub 2005 Sep 8. [PubMed:16148947 ]
  6. Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW: The novel Rab11-FIP/Rip/RCP family of proteins displays extensive homo- and hetero-interacting abilities. Biochem Biophys Res Commun. 2002 Apr 12;292(4):909-15. [PubMed:11944901 ]
  7. Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW: Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells. Biochem Biophys Res Commun. 2002 Dec 20;299(5):770-9. [PubMed:12470645 ]
  8. Jenne DE, Tinschert S, Dorschner MO, Hameister H, Stephens K, Kehrer-Sawatzki H: Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse. Genes Chromosomes Cancer. 2003 Jun;37(2):111-20. [PubMed:12696059 ]
  9. Hickson GR, Matheson J, Riggs B, Maier VH, Fielding AB, Prekeris R, Sullivan W, Barr FA, Gould GW: Arfophilins are dual Arf/Rab 11 binding proteins that regulate recycling endosome distribution and are related to Drosophila nuclear fallout. Mol Biol Cell. 2003 Jul;14(7):2908-20. Epub 2003 Apr 17. [PubMed:12857874 ]
  10. Wilson GM, Fielding AB, Simon GC, Yu X, Andrews PD, Hames RS, Frey AM, Peden AA, Gould GW, Prekeris R: The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis. Mol Biol Cell. 2005 Feb;16(2):849-60. Epub 2004 Dec 15. [PubMed:15601896 ]
  11. Krzyzaniak MA, Mach M, Britt WJ: HCMV-encoded glycoprotein M (UL100) interacts with Rab11 effector protein FIP4. Traffic. 2009 Oct;10(10):1439-57. doi: 10.1111/j.1600-0854.2009.00967.x. [PubMed:19761540 ]