| Identification |
|---|
| HMDB Protein ID
| HMDBP08546 |
| Secondary Accession Numbers
| |
| Name
| Ras-specific guanine nucleotide-releasing factor 1 |
| Synonyms
|
- GNRP
- Guanine nucleotide-releasing protein
- Ras-GRF1
- Ras-specific nucleotide exchange factor CDC25
|
| Gene Name
| RASGRF1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in Rho guanyl-nucleotide exchange factor activity |
| Specific Function
| Promotes the exchange of Ras-bound GDP by GTP |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| small gtpase regulator activity |
| ras guanyl-nucleotide exchange factor activity |
| rho guanyl-nucleotide exchange factor activity |
| enzyme regulator activity |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| guanyl-nucleotide exchange factor activity |
| Process |
| regulation of ras protein signal transduction |
| regulation of rho protein signal transduction |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
| intracellular signaling pathway |
| signaling |
| signaling pathway |
| intracellular signal transduction |
| small gtpase mediated signal transduction |
| regulation of cell communication |
| regulation of signal transduction |
| regulation of small gtpase mediated signal transduction |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 15q24.2 |
| SNPs
| RASGRF1 |
| Gene Sequence
|
>3828 bp
ATGCAGAAAGCCATCCGACTTAATGATGGCCACGTCGCGCCCCTGGGACTGCTGGCGCGC
AAGGACGGCACGCGCAAAGGCTACCTGAGCAAGCGGAGTTCGGACAACACAAAATGGCAA
ACCAAGTGGTTCGCGCTGCTGCAGAACCTGCTCTTCTACTTCGAGAGCGACTCGAGCTCG
CGGCCCTCGGGGCTTTACCTGCTGGAGGGCTGCGTCTGCGACCGCGCGCCCTCCCCCAAG
CCGGCGCTGTCGGCCAAGGAGCCGCTGGAGAAACAGCATTACTTCACGGTGAACTTCAGC
CATGAGAACCAGAAAGCCTTGGAGCTGAGGACAGAGGACGCAAAAGATTGTGACGAATGG
GTGGCAGCCATTGCACATGCCAGCTACAGGACCCTCGCCACAGAGCATGAGGCATTAATG
CAGAAATACCTGCACCTGCTGCAGATCGTGGAGACAGAGAAGACCGTGGCCAAGCAGCTT
CGGCAGCAGATCGAGGATGGGGAGATCGAGATCGAGCGGCTGAAGGCAGAGATCACATCC
CTGCTCAAGGACAATGAGCGCATCCAGTCCACCCAGACTGTCGCCCCCAACGATGAAGAC
AGCGACATCAAGAAAATTAAGAAGGTGCAGAGCTTCCTGCGGGGCTGGCTGTGCCGGCGG
AAGTGGAAGACCATCATCCAGGACTACATCCGGTCACCCCATGCTGACAGCATGCGCAAG
AGGAACCAGGTGGTGTTCAGCATGCTGGAGGCTGAGGCTGAGTACGTGCAGCAGCTGCAC
ATCCTTGTCAACAATTTCCTGCGCCCGCTGCGGATGGCCGCCAGCTCCAAGAAGCCTCCC
ATCACACACGACGACGTCAGCAGCATCTTCCTGAACAGCGAAACCATCATGTTTTTACAT
CAGATCTTTTACCAAGGCCTGAAGGCCCGCATCTCCAGCTGGCCCACGCTGGTCCTGGCT
GACCTACTTGACATCCTGCTGCCCATGCTCAACATCTACCAAGAGTTCGTCCGCAACCAC
CAGTACAGCCTGCAGATCCTGGCCCACTGCAAGCAGAACCGTGACTTCGACAAGCTGCTG
AAGCACTACGAGGCCAAGCCTGACTGCGAGGAGAGGACGTTGGAGACCTTCCTCACCTAC
CCCATGTTCCAGATCCCCAGGTACATCCTGACCCTCCATGACGTCCTGGCCCACACGCCT
CATGAGCACGTTGAGCGCAACAGCCTGGACTACGCCAAGTCCAAACTGGAGGAGCTGTCC
AGAATAATGCACGATGAAGTAAGTGAGACGGAGAACATCCGGAAAAACCTGGCCATCGAG
CGCATGATCATCGAAGGCTGTGAGATCCTCCTGGACACCAGCCAGACCTTTGTGAGACAA
GGTTCCCTCATTCAGGTGCCCATGTCTGAAAAGGGCAAGATCACCAGGGGGCGCCTGGGG
TCTCTCTCCCTAGAGAAAGAGGGCGAGCGACAGTGCTTCCTGTTTTCTAAGCATCTGATT
ATCTGTACCAGAGGCTCTGGAGGGAAGCTTCACTTGACCAAGAATGGAGTCATATCCCTC
ATTGACTGCACTTTATTGGAGGAGCCAGAAAGCACGGAGGAGGAAGCCAAAGGATCCGGC
CAAGACATAGATCACTTGGATTTCAAAATCGGGGTGGAGCCAAAGGATTCCCCGCCCTTT
ACAGTCATCCTAGTGGCCTCGTCCAGACAGGAGAAGGCAGCGTGGACCAGTGACATCAGC
CAGTGTGTGGATAACATCCGATGCAATGGGCTCATGATGAACGCATTTGAAGAAAATTCC
AAGGTCACTGTGCCGCAGATGATCAAGAGGACCAGGGAGGGGACCAGGGAAGCAGAAATG
AGCAGGTCCGACGCCTCCTTATATTGTGATGATGTTGACATTCGCTTCAGCAAAACCATG
AACTCCTGCAAAGTGCTGCAGATCCGCTACGCCAGTGTGGAGCGGCTGCTGGAGAGGCTG
ACGGACCTGCGCTTCCTGAGCATCGACTTCCTCAACACCTTCCTGCACTCCTACCGCGTC
TTCACCACCGCCATCGTGGTCCTGGACAAGCTCATTACCATCTACAAGAAGCCTATCAGT
GCCATTCCTGCCAGGTGGCTGAGGTCGCTGGAGCTCCTGTTTGCCAGTGGCCAGAACAAT
AAGCTCCTGTACGGTGAACCCCCCAAGTCCCCGCGCGCCACCCGCAAGTTCTCCTCGCCG
CCACCTCTGTCCATCACCAAGACATCGTCACCGAGCCGCCGGCGGAAGCTGATCTCCCTG
AACATCCCCATCATCACTGGCGGCAAGGCCCTGGACCTGGCCGGATCCCTCAGCTGCAAC
TCCAATGGCTACACCAGCATGTACTCGGCCATGTCACCCTTCAGCAAGGCCACGCTGGAC
ACCAGCAAGCTCTATGTGTCCAGCAGCTTCACCAACAAGATTCCAGATGAGGGCGATACG
ACCCCTGAGAAGCCCGAAGACCCTTCAGCGCTCAGCAAGCAGAGCTCAGAAGTCTCCATG
AGAGAGGAGTCAGATATTGATCAAAACCAGAGTGATGATGGTGATACTGAAACATCACCA
ACTAAATCTCCAACAACACCCAAATCAGTCAAAAACAAAAATTCTTCAGAGTTCCCACTC
TTTTCCTATAACAATGGAGTCGTCATGACCTCCTGTCGTGAACTGGACAATAACCGCAGT
GCCTTGTCGGCCGCCTCTGCCTTTGCCATAGCAACCGCCGGGGCCAACGAGGGCACCCCA
AACAAGGAGAAGTACCGGAGGATGTCCTTAGCCAGTGCAGGGTTTCCCCCAGACCAGAGG
AATGGAGACAAGGAGTTTGTGATCCGCAGAGCAGCCACCAATCGTGTCTTGAACGTGCTC
CGCCACTGGGTGTCCAAGCACTCTCAGGACTTTGAGACCAACGATGAGCTCAAATGCAAG
GTGATCGGCTTCCTGGAAGAAGTCATGCACGACCCGGAGCTCCTGACCCAGGAGCGGAAA
GCTGCAGCCAACATCATCAGGACTCTGACCCAGGAGGACCCAGGTGACAACCAGATCACG
CTGGAGGAGATCACGCAGATGGCTGAAGGCGTGAAGGCTGAGCCCTTTGAAAACCACTCA
GCCCTGGAGATCGCGGAGCAGCTGACCCTGCTGGATCACCTCGTCTTCAAGAAGATTCCT
TATGAGGAGTTCTTCGGACAAGGATGGATGAAACTGGAAAAGAATGAAAGGACCCCTTAT
ATCATGAAAACCACTAAGCACTTCAATGACATCAGTAACTTGATTGCTTCAGAAATCATC
CGCAATGAGGACATCAACGCCAGGGTGAGCGCCATCGAGAAGTGGGTGGCCGTAGCTGAC
ATATGCCGCTGCCTCCACAACTACAATGCCGTACTGGAGATCACCTCGTCCATGAACCGC
AGTGCAATCTTCCGGCTCAAAAAGACGTGGCTCAAAGTCTCTAAGCAGACTAAAGCTTTG
ATTGATAAGCTCCAAAAGCTTGTGTCATCAGAGGGCAGATTTAAGAATCTCAGAGAAGCT
CTGAAAAATTGTGACCCACCCTGTGTCCCTTACCTGGGGATGTACCTCACCGACCTGGCC
TTCATCGAGGAGGGGACGCCCAATTACACGGAAGACGGCCTGGTCAACTTCTCCAAGATG
AGGATGATATCCCATATTATCCGAGAGATTCGCCAGTTTCAACAAACTGCCTACAAAATA
GAGCACCAAGCAAAGGTAACGCAATATTTACTGGACCAATCTTTTGTAATGGATGAAGAA
AGCCTCTACGAGTCTTCTCTCCGAATAGAACCAAAACTCCCCACCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1275 |
| Molecular Weight
| 145381.4 |
| Theoretical pI
| 7.3 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ras-specific guanine nucleotide-releasing factor 1
MQKAIRLNDGHVAPLGLLARKDGTRKGYLSKRSSDNTKWQTKWFALLQNLLFYFESDSSS
RPSGLYLLEGCVCDRAPSPKPALSAKEPLEKQHYFTVNFSHENQKALELRTEDAKDCDEW
VAAIAHASYRTLATEHEALMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEIERLKAEITS
LLKDNERIQSTQTVAPNDEDSDIKKIKKVQSFLRGWLCRRKWKTIIQDYIRSPHADSMRK
RNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLH
QIFYQGLKARISSWPTLVLADLLDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLL
KHYEAKPDCEERTLETFLTYPMFQIPRYILTLHDVLAHTPHEHVERNSLDYAKSKLEELS
RIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGKITRGRLG
SLSLEKEGERQCFLFSKHLIICTRGSGGKLHLTKNGVISLIDCTLLEEPESTEEEAKGSG
QDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNAFEENS
KVTVPQMIKRTREGTREAEMSRSDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERL
TDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPARWLRSLELLFASGQNN
KLLYGEPPKSPRATRKFSSPPPLSITKTSSPSRRRKLISLNIPIITGGKALDLAGSLSCN
SNGYTSMYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSM
REESDIDQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRS
ALSAASAFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVL
RHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQIT
LEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPY
IMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNR
SAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLA
FIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEE
SLYESSLRIEPKLPT
|
| External Links |
|---|
| GenBank ID Protein
| 433720 |
| UniProtKB/Swiss-Prot ID
| Q13972 |
| UniProtKB/Swiss-Prot Entry Name
| RGRF1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| L26584 |
| GeneCard ID
| RASGRF1 |
| GenAtlas ID
| RASGRF1 |
| HGNC ID
| HGNC:9875 |
| References |
|---|
| General References
| - Anborgh PH, Qian X, Papageorge AG, Vass WC, DeClue JE, Lowy DR: Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf. Mol Cell Biol. 1999 Jul;19(7):4611-22. [PubMed:10373510 ]
- Wei W, Das B, Park W, Broek D: Cloning and analysis of human cDNAs encoding a 140-kDa brain guanine nucleotide-exchange factor, Cdc25GEF, which regulates the function of Ras. Gene. 1994 Dec 30;151(1-2):279-84. [PubMed:7828890 ]
- Schweighoffer F, Faure M, Fath I, Chevallier-Multon MC, Apiou F, Dutrillaux B, Sturani E, Jacquet M, Tocque B: Identification of a human guanine nucleotide-releasing factor (H-GRF55) specific for Ras proteins. Oncogene. 1993 Jun;8(6):1477-85. [PubMed:7684828 ]
- Wei W, Mosteller RD, Sanyal P, Gonzales E, McKinney D, Dasgupta C, Li P, Liu BX, Broek D: Identification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7100-4. [PubMed:1379731 ]
|
