Human Metabolome Database: Showing Protein Secretion-regulating guanine nucleotide exchange factor (HMDBP08584)

Identification Biological properties Gene properties Protein properties External links References XML Show 5 metabolites

Identification
HMDB Protein ID	HMDBP08584
Secondary Accession Numbers	14299
Name	Secretion-regulating guanine nucleotide exchange factor
Synonyms	Deafness locus-associated putative guanine nucleotide exchange factor DelGEF Guanine nucleotide exchange factor-related protein
Gene Name	SERGEF
Protein Type	Unknown
Biological Properties
General Function	Involved in protein binding
Specific Function	Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process
Pathways	Not Available
Reactions	Not Available
GO Classification	Not Available
Cellular Location	Nucleus Cytoplasm
Gene Properties
Chromosome Location	Chromosome:1
Locus	11p14.3
SNPs	SERGEF
Gene Sequence	>1377 bp ATGGAGCGCGAGCCCAGCGCCTCGGAGGCCGCCCCCGCGGCGGCCGCGCTCTTCGCCTGG GGTGCAAATAGCTATGGGCAACTTGGCCTCGGCCATAAGGAAGATGTGCTGTTGCCCCAG CAACTGAATGACTTCTGTAAACCCAGGAGTGTCAGGAGGATCACAGGAGGAGGGGGCCAC TCTGCAGTTGTCACAGATGGAGGAGACCTCTTTGTTTGTGGCCTGAACAAAGATGGGCAA CTGGGGCTTGGTCACACAGAGGATATCCCATATTTTACCCCCTGCAAATCCCTCTTTGGC TGTCCCATCCAACAGGTGGCCTGTGGCTGGGATTTTACGATTATGCTCACAGAAAATGGT CAAGTTCTATCATGTGGATCCAACTCCTTTGGCCAGTTAGGAGTTCCTCATGGACCTCGA AGATGTGTGGTTCCCCAGGCCATTGAGCTCCATAAAGAGAAGGTTGTTTGTATTGCTGCT GGACTGAGGCATGCAGTAGCTGCTACAGCGAGTGGCATCGTGTTCCAGTGGGGGACTGGT TTGGCATCATGTGGACGACGGTTGTGCCCTGGGCAGACTCTTCCATTGTTTTTCACAGCA AAGGAACCAAGCAGAGTGACAGGTCTAGAGAATTCTAAAGCAATGTGTGTTCTTGCTGGC TCAGACCACTCAGCTTCATTAACAGATGCAGGAGAGGTGTATGTTTGGGGAAGCAACAAG CATGGGCAACTGGCTAATGAGGCTGCTTTCCTTCCTGTGCCCCAGAAAATAGAAGCACAT TGTTTCCAGAATGAAAAGGTCACTGCCATCTGGAGTGGATGGACACACCTGGTTGCCCAG ACAGAAACTGGCAAGATGTTTACCTGGGGCCGAGCAGACTATGGTCAGCTAGGGAGGAAG TTGGAGACTTATGAAGGCTGGAAACTAGAAAAGCAAGATTCATTTCTCCCCTGTTCAAGA CCACCGAACAGCATGCCTTCATCTCCGCATTGCTTAACTGGAGCAACTGAGGTCTCTTGT GGCTCAGAGCATAATTTGGCAATAATTGGTGGAGTGTGTTACTCTTGGGGCTGGAATGAG CATGGCATGTGCGGAGATGGCACTGAAGCCAACGTCTGGGCCCCAAAGCCGGTGCAGGCT CTGCTGTCATCGTCAGGACTCCTTGTGGGCTGTGGGGCTGGCCACTCCTTGGCCCTCTGC CAGCTGCCAGCTCACCCTGCATTGGTCCAGGACCCCAAGGTCACCTACCTTTCCCCAGAT GCCATCGAGGACACTGAATCTCAGAAAGCCATGGACAAAGAGAGAAACTGGAAGGAAAGA CAATCAGAAACTTCAACCCAAAGCCAATCTGACTGGTCCAGAAATGGGGGACTGTGA
Protein Properties
Number of Residues	458
Molecular Weight	48981.0
Theoretical pI	6.44
Pfam Domain Function	RCC1 (PF00415 )
Signals	None
Transmembrane Regions	None
Protein Sequence	>Secretion-regulating guanine nucleotide exchange factor MEREPSASEAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGH SAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENG QVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTG LASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNK HGQLANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRK LETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAIIGGVCYSWGWNE HGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLALCQLPAHPALVQDPKVTYLSPD AIEDTESQKAMDKERNWKERQSETSTQSQSDWSRNGGL
External Links
GenBank ID Protein	6434157
UniProtKB/Swiss-Prot ID	Q9UGK8
UniProtKB/Swiss-Prot Entry Name	SRGEF_HUMAN
PDB IDs	Not Available
GenBank Gene ID	AJ243950
GeneCard ID	SERGEF
GenAtlas ID	SERGEF
HGNC ID	HGNC:17499
References
General References	Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ] Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007 May 25;316(5828):1160-6. [PubMed:17525332 ] Sjolinder M, Uhlmann J, Ponstingl H: DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion. FEBS Lett. 2002 Dec 4;532(1-2):211-5. [PubMed:12459492 ] Uhlmann J, Wiemann S, Ponstingl H: DelGEF, an RCC1-related protein encoded by a gene on chromosome 11p14 critical for two forms of hereditary deafness. FEBS Lett. 1999 Oct 22;460(1):153-60. [PubMed:10571079 ]