| Identification |
|---|
| HMDB Protein ID
| HMDBP08592 |
| Secondary Accession Numbers
| |
| Name
| Synaptotagmin-like protein 5 |
| Synonyms
|
Not Available
|
| Gene Name
| SYTL5 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in Rab GTPase binding |
| Specific Function
| May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Function |
| small gtpase regulator activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
| enzyme regulator activity |
| rab gtpase binding |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| Process |
| establishment of localization |
| transport |
| protein transport |
| intracellular protein transport |
|
| Cellular Location
|
- Peripheral membrane protein
- Membrane
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| SYTL5 |
| Gene Sequence
|
>2193 bp
ATGTCTAAGAACTCAGAGTTCATCAATCTGTCATTTTTATTAGATCATGAGAAGGAAATG
ATCCTGGGCGTCCTAAAGAGAGATGAATATTTGAAAAAAGTGGAGGACAAGAGAATAAGG
AAGCTGAAAAATGAACTCTTAGAAGCAAAACGTAGAAGTGGGAAAACTCAACAAGAGGCC
AGCAGAGTTTGTGTTCACTGTCACAGAAACCTGGGCCTAATCTTTGACCGGGGAGACCCT
TGTCAGGCTTGCTCACTGAGGGTATGCAGGGAGTGTCGAGTTGCAGGCCCCAATGGCAGC
TGGAAGTGCACTGTCTGTGACAAAATCGCGCAGCTAAGGATTATAACTGGTGAGTGGTTT
TTTGAAGAAAAGGCAAAACGTTTCAAGCAAGTCAATGTTCTCGGCACTGATGTTGTCCGA
CAGTCCATTTTAAGAAGAAGTCCAGGAGCTGAAGAAGTACAGAGCCAAGAGCAAACCCGC
CAGGATGCAGAAAAGTCAGACACTTCACCTGTTGCTGGGAAGAAGGCCAGCCATGATGGG
CCCAAGAGAAAGGGATTTCTTCTTAGCAAGTTCAGATCGGCAACCAGAGGAGAAATCATA
ACTCCCAAAACTGACACTGGGCGGAGCTATAGCTTGGACTTAGACGGTCAACATTTTCGG
AGTTTAAAATCACCTCCTGGTTCAGACAGGGGAAGCACTGGCTCATCAGATCTCAATGAC
CAGGAACCTGGTCCTAGGACCCCGAAGAGCAGTCGGAGCAATGGTGTGACCCCAGGCACT
CAGAGTTCACCAGCCCCAAGCACACGAACTGTGACCTCAGTCATCAGTAGAGAGTATGGT
TTTGAAAATTCCATGGATTTGGCTGCTATTGAAGGTACCTCTCAGGAGCTCACAAAGAGT
CACCGCAGAAACACTTCTGGCACACCTTCCATAGCAGTGTCTGGAACCTCTCTCTCCTCA
GATCAGAGTCGATCTGAGTTAGATTTGAGTGAGTCATTTACAGAAGACTCAGAGGATACT
GTAAGCATAAGAAGCAAGTCTGTCCCTGGGGCTTTAGACAAGGACTCCTTGGAAGAGACT
GAAGAAAGCATTGATGCCTTAGTGTCCTCGCAGTTATCTACAAACACTCACCGTCTGGCA
AGTGGCCTATCAACTACCAGCCTTAACAGCATGATGAGCGTTTACAGTGAAACGGGAGAC
TATGGCAACGTGAAAGTCAGTGGTGAAATCCTTCTCCATATCAGCTACTGCTACAAAACT
GGTGGGCTGTACATTTTTGTCAAGAATTGCAGAAATCTGGCCATAGGAGATGAAAAGAAA
CAGAGGACAGATGCTTATGTCAAGTCATATCTTCTTCCTGACAAGTCCCGGAACAACAAG
CGTAAGACCAAAATCAGAACAGGCACCAATCCAGAATTCAATGAAACACTAAAGTACACT
ATCAGCCATACCCAGCTGGAAACAAGAACTCTGCAGCTCTCAGTCTGGCACTATGATCGA
TTTGGACGTAATAGCTTCCTCGGGGAAGTAGAGATTCCTTTTGACTCATGGAACTTTGAA
AATCCAACTGATGAGTGGTTTGTGCTTCAACCCAAGGTGGAGTTTGCTCCTGATATTGGC
CTTCAATACAAAGGAGAGCTGACAGTTGTTTTACGTTACATTCCCCCAGAAGAGAACCTG
ATGCTTCCACCAGAACAACTCCAAGGAAATAAGACTTTTAAAAAGGGAAAGAAGAAGGAG
TCACCTGTAATCTCTGGAGGAATACTAGAAGTGTTCATCAAAGAGGCAAAGAATTTGACA
GCAGTGAAGTCAGGAGGCACTTCTGATAGCTTTGTGAAGGGCTACCTGCTCCCTGATGAT
AGCAAAGCCACCAAGCACAAAACTCTGGTAATAAAAAAGAGTGTTAACCCTCAGTGGAAT
CATACATTCATGTTCAGTGGCATCCATCCCCAGGATATAAAGAATGTTTGCCTAGAACTT
ACTATCTGGGACAAGGAGGCCTTTTCCAGCAACATCTTTCTGGGAGGAGTTCGTTTGAAT
TCTGGAAGTGGTGTGAGCCATGGGAAGAACGTGGATTGGATGGACTCTCAGGGGGAAGAG
CAGCGCCTTTGGCAGAAGATGGCCAACAACCCTGGAACTCCCTTTGAGGGTGTACTCATG
CTTCGTTCCAGCATGGGAAAATGTAGGCTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 730 |
| Molecular Weight
| 81522.3 |
| Theoretical pI
| 9.11 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Synaptotagmin-like protein 5
MSKNSEFINLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEA
SRVCVHCHRNLGLIFDRGDPCQACSLRVCRECRVAGPNGSWKCTVCDKIAQLRIITGEWF
FEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHDG
PKRKGFLLSKFRSATRGEIITPKTDTGRSYSLDLDGQHFRSLKSPPGSDRGSTGSSDLND
QEPGPRTPKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMDLAAIEGTSQELTKS
HRRNTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEET
EESIDALVSSQLSTNTHRLASGLSTTSLNSMMSVYSETGDYGNVKVSGEILLHISYCYKT
GGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTGTNPEFNETLKYT
ISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDIG
LQYKGELTVVLRYIPPEENLMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLT
AVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLEL
TIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEGVLM
LRSSMGKCRL
|
| External Links |
|---|
| GenBank ID Protein
| 20126681 |
| UniProtKB/Swiss-Prot ID
| Q8TDW5 |
| UniProtKB/Swiss-Prot Entry Name
| SYTL5_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB080222 |
| GeneCard ID
| SYTL5 |
| GenAtlas ID
| SYTL5 |
| HGNC ID
| HGNC:15589 |
| References |
|---|
| General References
| - Kuroda TS, Fukuda M, Ariga H, Mikoshiba K: Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains. Biochem Biophys Res Commun. 2002 May 10;293(3):899-906. [PubMed:12051743 ]
|
