Hmdb loader
Identification
HMDB Protein ID HMDBP08596
Secondary Accession Numbers
  • 14311
Name Tubulin alpha-3C/D chain
Synonyms
  1. Alpha-tubulin 2
  2. Alpha-tubulin 3C/D
  3. Tubulin alpha-2 chain
Gene Name TUBA3C
Protein Type Unknown
Biological Properties
General Function Involved in structural molecule activity
Specific Function Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain
Pathways Not Available
Reactions Not Available
GO Classification
Component
macromolecular complex
protein complex
microtubule
Function
purine nucleotide binding
binding
nucleotide binding
catalytic activity
hydrolase activity
guanyl nucleotide binding
guanyl ribonucleotide binding
gtp binding
structural molecule activity
gtpase activity
nucleoside-triphosphatase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity
Process
cellular process
cellular component organization or biogenesis
cellular component organization
cellular component assembly
macromolecular complex assembly
cellular protein complex assembly
microtubule-based process
microtubule-based movement
protein complex assembly
protein polymerization
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location Chromosome:1
Locus 13q11
SNPs TUBA3C
Gene Sequence
>1353 bp
ATGCGTGAGTGTATCTCTATCCACGTGGGGCAGGCAGGAGTCCAGATCGGCAATGCCTGC
TGGGAACTGTACTGCCTGGAACATGGAATTCAGCCCGATGGTCAGATGCCAAGTGATAAA
ACCATTGGTGGTGGGGACGACTCCTTCAACACGTTCTTCAGTGAGACTGGAGCTGGCAAG
CACGTGCCCAGAGCAGTGTTTGTGGACCTGGAGCCCACTGTGGTCGATGAAGTGCGCACA
GGAACCTATAGGCAGCTCTTCCACCCAGAGCAGCTGATCACCGGGAAGGAAGATGCGGCC
AATAATTACGCCAGAGGCCATTACACCATCGGCAAGGAGATCGTCGACCTGGTCCTGGAC
CGGATCCGCAAACTGGCGGATCTGTGCACGGGACTGCAGGGCTTCCTCATCTTCCACAGT
TTTGGGGGTGGCACTGGCTCTGGGTTCGCATCTCTGCTCATGGAGCGGCTCTCAGTGGAT
TACGGCAAGAAGTCCAAGCTAGAATTTGCCATTTACCCAGCCCCCCAGGTCTCCACGGCC
GTGGTGGAGCCCTACAACTCCATCCTGACCACCCACACGACCCTGGAACATTCTGACTGT
GCCTTCATGGTCGACAATGAAGCCATCTATGACATATGTCGGCGCAACCTGGACATCGAG
CGTCCCACGTACACCAACCTCAATCGCCTGATTGGGCAGATCGTGTCCTCCATCACGGCC
TCCCTGCGATTTGACGGGGCCCTGAATGTGGACTTGACGGAATTCCAGACCAACCTAGTG
CCGTACCCCCGCATCCACTTCCCCCTGGCCACCTACGCCCCGGTCATCTCAGCCGAGAAG
GCCTACCACGAGCAGCTGTCCGTGGCTGAGATCACCAATGCCTGCTTCGAGCCAGCCAAT
CAGATGGTCAAGTGTGACCCTCGCCACGGCAAGTACATGGCCTGCTGCATGTTGTACAGG
GGGGATGTGGTCCCGAAAGATGTCAACGCGGCCATCGCCACCATCAAGACCAAGCGCACC
ATCCAGTTTGTAGATTGGTGCCCAACTGGATTTAAGGTGGGCATTAACTACCAGCCCCCC
ACGGTGGTCCCTGGGGGAGACCTGGCCAAGGTGCAGCGGGCTGTGTGCATGCTGAGCAAC
ACCACGGCCATCGCGGAGGCCTGGGCTCGCCTGGACCATAAGTTCGATCTCATGTATGCC
AAGCGGGCCTTTGTGCACTGGTACGTGGGAGAAGGCATGGAGGAGGGGGAGTTCTCTGAG
GCCCGCGAGGACCTGGCAGCTCTGGAGAAGGATTATGAAGAGGTGGGCGTGGATTCCGTG
GAAGCCGAGGCTGAAGAAGGTGAAGAATACTGA
Protein Properties
Number of Residues 450
Molecular Weight 49959.1
Theoretical pI 4.74
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Tubulin alpha-3C/D chain
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLD
RIRKLADLCTGLQGFLIFHSFGGGTGSGFASLLMERLSVDYGKKSKLEFAIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDLAALEKDYEEVGVDSVEAEAEEGEEY
GenBank ID Protein 17921993
UniProtKB/Swiss-Prot ID Q13748
UniProtKB/Swiss-Prot Entry Name TBA3C_HUMAN
PDB IDs
GenBank Gene ID NM_006001.1
GeneCard ID TUBA3C
GenAtlas ID TUBA3C
HGNC ID HGNC:12408
References
General References
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  2. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  3. Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. J Proteome Res. 2007 Nov;6(11):4150-62. Epub 2007 Oct 9. [PubMed:17924679 ]
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  5. Rogowski K, Juge F, van Dijk J, Wloga D, Strub JM, Levilliers N, Thomas D, Bre MH, Van Dorsselaer A, Gaertig J, Janke C: Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. Cell. 2009 Jun 12;137(6):1076-87. doi: 10.1016/j.cell.2009.05.020. [PubMed:19524510 ]
  6. Dode C, Weil D, Levilliers J, Crozet F, Chaib H, Levi-Acobas F, Guilford P, Petit C: Sequence characterization of a newly identified human alpha-tubulin gene (TUBA2). Genomics. 1998 Jan 1;47(1):125-30. [PubMed:9465305 ]