Hmdb loader
Identification
HMDB Protein ID HMDBP08607
Secondary Accession Numbers
  • 14322
Name Tubulin-specific chaperone D
Synonyms
  1. Beta-tubulin cofactor D
  2. SSD-1
  3. Tubulin-folding cofactor D
  4. tfcD
Gene Name TBCD
Protein Type Unknown
Biological Properties
General Function Involved in binding
Specific Function Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB)
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:1
Locus 17q25.3
SNPs TBCD
Gene Sequence
>3579 bp
ATGGCCCTGAGCGACGAACCGGCCGCGGGCGGCCCCGAGGAGGAGGCGGAGGACGAGACA
CTGGCCTTTGGCGCGGCGCTGGAAGCGTTCGGCGAGAGCGCGGAGACCCGGGCGCTGCTG
GGCCGCCTGCGGGAGGTGCACGGCGGCGGCGCGGAGCGCGAGGTGGCCCTGGAGCGGTTC
CGCGTAATAATGGACAAATACCAGGAGCAGCCTCATCTGTTGGACCCGCACCTTGAATGG
ATGATGAACTTGTTGTTGGACATAGTGCAAGATCAGACATCTCCAGCTTCCCTTGTACAT
CTGGCTTTTAAATTTCTTTACATCATCACCAAGGTTCGAGGCTATAAAACATTTCTTCGT
TTATTTCCTCATGAAGTTGCCGATGTAGAGCCTGTTTTAGATTTGGTCACAATTCAGAAT
CCCAAGGACCATGAAGCTTGGGAAACCCGCTACATGCTTTTGCTCTGGCTCTCCGTGACC
TGCCTGATCCCTTTTGATTTTTCTCGCCTTGACGGGAACCTCCTCACCCAGCCTGGGCAA
GCACGAATGTCCATAATGGACCGTATTCTCCAAATAGCAGAGTCCTACTTGATTGTCAGT
GACAAGGCCCGAGATGCAGCTGCTGTCCTTGTGTCCAGATTTATCACACGTCCTGATGTC
AAGCAAAGCAAGATGGCTGAGTTCCTGGACTGGAGCCTGTGCAATCTGGCCCGTTCCTCC
TTCCAGACCATGCAGGGGGTCATCACCATGGATGGGACGCTGCAGGCCCTGGCACAAATA
TTTAAACATGGAAAACGTGAAGACTGTTTGCCCTATGCTGCCACTGTCCTCAGGTGCCTC
GATGGCTGCAGACTCCCTGAGAGCAACCAGACCCTGCTGCGGAAGCTGGGGGTGAAGCTT
GTGCAGCGACTGGGGCTGACATTCCTGAAGCCGAAGGTGGCAGCATGGAGGTACCAGCGT
GGCTGCCGATCTTTGGCTGCAAATCTGCAGCTCCTCACTCAGGGTCAGAGTGAGCAGAAG
CCACTCATCCTGACCGAAGATGACGACGAAGATGACGACGTCCCAGAGGGGGTGGAGCGT
GTGATAGAGCAGCTGCTGGTCGGGCTGAAGGACAAGGACACGGTCGTGCGGTGGTCTGCA
GCCAAGGGCATCGGTAGGATGGCTGGCAGGCTTCCCAGAGCCCTGGCGGATGATGTGGTC
GGGTCTGTGCTGGACTGCTTCAGTTTCCAGGAGACTGACAAGGCGTGGCATGGGGGATGT
CTGGCGCTGGCAGAGCTGGGCAGGAGAGGCCTGTTGCTGCCGTCTCGACTCGTGGATGTT
GTCGCCGTGATCCTGAAGGCGCTGACCTACGACGAGAAGCGGGGTGCCTGCAGCGTGGGC
ACCAACGTCAGGGACGCCGCCTGCTACGTGTGCTGGGCCTTCGCGCGTGCCTATGAGCCT
CAGGAGCTGAAGCCCTTTGTGACTGCAATCTCGAGTGCACTGGTGATTGCTGCGGTGTTT
GACCGAGACATAAACTGCAGAAGAGCAGCCTCTGCCGCCTTCCAGGAGAATGTGGGGAGA
CAGGGCACTTTCCCTCATGGTATTGATATTTTGACCACAGCTGACTATTTTGCCGTCGGT
AACAGATCCAACTGTTTCCTGGTTATAAGTGTGTTTATTGCCGGCTTTCCTGAGTACACG
CAGCCAATGATAGACCACCTGGTTACCATGAAGATCAGCCACTGGGATGGGGTCATCCGA
GAGTTGGCTGCGAGGGCGCTGCACAACCTGGCCCAGCAGGCACCCGAGTTCAGCGCCACG
CAAGTCTTCCCGAGGCTGCTGTCCATGACACTGAGTCCAGATCTTCACATGAGGCATGGG
TCGATTCTCGCCTGCGCAGAAGTTGCTTACGCCTTGTACAAACTTGCAGCCCAAGAGAAC
AGGCCCGTCACGGACCATCTGGACGAGCAGGCAGTGCAGGGCCTGAAGCAGATTCACCAG
CAGCTCTATGATCGTCAGTTATACAGGGGTCTGGGAGGACAGCTCATGAGACAAGCAGTG
TGTGTTTTAATAGAAAAGTTGTCACTTTCCAAAATGCCCTTTAGAGGTGACACCGTAATT
GATGGTTGGCAATGGCTGATAAATGACACTTTGAGACATCTCCATCTCATCTCAAGTCAC
TCCCGCCAGCAGATGAAGGATGCAGCAGTCTCGGCCCTGGCTGCTCTATGCAGTGAATAT
TACATGAAGGAGCCGGGGGAGGCAGATCCCGCAATTCAGGAGGAGCTGATCACGCAGTAC
CTGGCTGAGCTTCGGAACCCCGAGGAGATGACTCGCTGTGGCTTCTCGTTGGCCTTGGGC
GCCCTTCCAGGCTTCCTTCTGAAAGGCCGGCTCCAGCAGGTTCTCACAGGTTTAAGAGCA
GTTACCCACACTTCCCCCGAGGACGTAAGTTTTGCTGAGTCCAGGAGAGACGGCTTGAAG
GCCATTGCGAGGATTTGCCAGACTGTTGGTGTGAAAGCAGGAGCCCCAGACGAAGCTGTG
TGCGGAGAGAATGTTTCCCAGATTTACTGTGCGCTGCTGGGCTGCATGGACGACTACACC
ACGGACAGCAGAGGGGACGTGGGCACCTGGGTCCGCAAGGCCGCCATGACCAGTCTGATG
GATCTGACACTTCTGCTGGCTCGGAGCCAGCCTGAGCTGATCGAGGCCCATACCTGTGAG
CGCATCATGTGCTGTGTGGCCCAGCAGGCCAGTGAGAAGATTGACCGTTTCCGTGCTCAC
GCCGCCAGCGTGTTCCTGACGCTCCTGCACTTTGACAGCCCTCCCATCCCCCACGTGCCC
CACCGAGGAGAACTGGAAAAGCTGTTTCCCAGGTCCGATGTGGCCTCCGTGAACTGGAGT
GCACCTTCCCAGGCCTTCCCACGCATCACCCAGCTCCTTGGGCTGCCCACCTACCGCTAC
CACGTCCTGCTGGGGCTAGTCGTGTCCCTGGGCGGCTTGACGGAGTCGACGATCCGGCAC
TCCACCCAGAGCCTCTTTGAGTACATGAAGGGCATTCAGAGCGACCCGCAGGCCCTGGGC
AGCTTCAGCGGGACCCTTCTGCAGATCTTTGAGGACAACCTTCTGAATGAGAGGGTGTCC
GTGCCGCTGCTGAAGACGCTGGACCACGTGCTCACCCACGGCTGCTTCGACATCTTCACC
ACGGAGGAGGACCACCCCTTTGCTGTGAAGTTGCTTGCGCTCTGTAAGAAAGAAATCAAG
AATTCAAAAGATATCCAGAAGCTCCTGTCAGGCATCGCAGTGTTCTGCGAGATGGTGCAG
TTCCCCGGCGACGTGAGGAGGCAGGCCCTCCTGCAGCTGTGTCTGCTCCTCTGCCACCGT
TTCCCGCTGATCCGGAAGACCACGGCCAGCCAGGTGTACGAGACATTGCTCACCTACAGT
GACGTCGTGGGCGCGGATGTGCTGGACGAGGTGGTGACTGTGCTCAGTGACACTGCGTGG
GACGCGGAGCTTGCAGTGGTGAGAGAGCAGCGCAACCGTCTGTGTGACCTTCTGGGCGTA
CCCAGGCCCCAGCTGGTGCCCCAGCCTGGTGCCTGCTGA
Protein Properties
Number of Residues 1192
Molecular Weight 132598.5
Theoretical pI 6.11
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Tubulin-specific chaperone D
MALSDEPAAGGPEEEAEDETLAFGAALEAFGESAETRALLGRLREVHGGGAEREVALERF
RVIMDKYQEQPHLLDPHLEWMMNLLLDIVQDQTSPASLVHLAFKFLYIITKVRGYKTFLR
LFPHEVADVEPVLDLVTIQNPKDHEAWETRYMLLLWLSVTCLIPFDFSRLDGNLLTQPGQ
ARMSIMDRILQIAESYLIVSDKARDAAAVLVSRFITRPDVKQSKMAEFLDWSLCNLARSS
FQTMQGVITMDGTLQALAQIFKHGKREDCLPYAATVLRCLDGCRLPESNQTLLRKLGVKL
VQRLGLTFLKPKVAAWRYQRGCRSLAANLQLLTQGQSEQKPLILTEDDDEDDDVPEGVER
VIEQLLVGLKDKDTVVRWSAAKGIGRMAGRLPRALADDVVGSVLDCFSFQETDKAWHGGC
LALAELGRRGLLLPSRLVDVVAVILKALTYDEKRGACSVGTNVRDAACYVCWAFARAYEP
QELKPFVTAISSALVIAAVFDRDINCRRAASAAFQENVGRQGTFPHGIDILTTADYFAVG
NRSNCFLVISVFIAGFPEYTQPMIDHLVTMKISHWDGVIRELAARALHNLAQQAPEFSAT
QVFPRLLSMTLSPDLHMRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQ
QLYDRQLYRGLGGQLMRQAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSH
SRQQMKDAAVSALAALCSEYYMKEPGEADPAIQEELITQYLAELRNPEEMTRCGFSLALG
ALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAV
CGENVSQIYCALLGCMDDYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCE
RIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEKLFPRSDVASVNWS
APSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALG
SFSGTLLQIFEDNLLNERVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIK
NSKDIQKLLSGIAVFCEMVQFPGDVRRQALLQLCLLLCHRFPLIRKTTASQVYETLLTYS
DVVGADVLDEVVTVLSDTAWDAELAVVREQRNRLCDLLGVPRPQLVPQPGAC
GenBank ID Protein 41350333
UniProtKB/Swiss-Prot ID Q9BTW9
UniProtKB/Swiss-Prot Entry Name TBCD_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_005993.4
GeneCard ID TBCD
GenAtlas ID TBCD
HGNC ID HGNC:11581
References
General References
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