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Identification
HMDB Protein ID HMDBP08619
Secondary Accession Numbers
  • 14334
Name Exportin-4
Synonyms
  1. Exp4
Gene Name XPO4
Protein Type Unknown
Biological Properties
General Function Involved in binding
Specific Function Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
Cellular Location
  1. Nucleus
  2. Cytoplasm
Gene Properties
Chromosome Location Chromosome:1
Locus 13q11
SNPs XPO4
Gene Sequence
>3456 bp
ATGATGGCGGCGGCGCTGGGGCCCCCAGAAGTGATCGCTCAGCTGGAGAACGCGGCTAAA
GTTCTGATGGCACCACCTTCCATGGTCAATAATGAACAACGCCAGCATGCAGAGCACATA
TTCTTATCATTTAGGAAATCAAAATCACCATTTGCAGTTTGCAAGCATATTTTGGAAACT
AGTAAAGTGGACTATGTCCTCTTTCAAGCTGCCACAGCCATAATGGAAGCAGTTGTCCGA
GAGTGGATTCTCTTGGAAAAAGGTAGCATCGAGTCTCTGCGAACATTCCTTTTAACCTAT
GTCTTACAAAGGCCCAACCTTCAAAAGTATGTTCGGGAACAGATTCTACTAGCAGTAGCA
GTAATTGTAAAAAGAGGATCATTAGATAAATCAATTGACTGCAAAAGCATTTTTCATGAA
GTCAGCCAGTTGATTAGTAGTGGCAATCCCACTGTGCAAACTCTGGCCTGTTCTATTCTG
ACTGCGCTATTGAGTGAATTTTCAAGTTCAAGTAAAACTAGCAACATTGGATTGAGCATG
GAATTCCATGGTAACTGCAAAAGAGTTTTTCAGGAAGAAGACCTTCGTCAGATCTTCATG
TTAACTGTTGAAGTTCTGCAGGAGTTCAGCAGGCGGGAAAACCTCAATGCTCAGATGTCT
TCAGTATTTCAGCGTTACCTTGCACTCGCCAATCAAGTCTTGAGCTGGAACTTTCTTCCT
CCAAATTTGGGCAGACATTATATAGCTATGTTTGAATCCTCGCAAAATGTGCTGTTGAAG
CCAACAGAGTCCTGGCGGGAGACTCTTCTGGACAGCAGAGTTATGGAGCTTTTCTTCACA
GTACATCGAAAAATCAGAGAAGATTCAGATATGGCACAAGATTCTCTGCAGTGCCTTGCC
CAGTTAGCTTCTCTTCATGGACCCATCTTCCCAGATGAAGGATCACAAGTTGATTATCTA
GCACACTTCATTGAGGGATTACTGAATACTATCAATGGAATTGAAATAGAAGATTCTGAA
GCTGTGGGGATCTCCAGCATTATCAGCAACCTGATAACCGTGTTCCCACGAAATGTTTTA
ACTGCCATTCCAAGTGAACTTTTCTCCTCCTTTGTTAACTGCCTCACACACCTCACTTGT
TCTTTTGGGCGAAGTGCTGCATTGGAAGAAGTGCTTGATAAAGATGACATGGTATACATG
GAAGCATATGATAAATTGTTGGAGTCCTGGTTAACTTTGGTTCAAGATGACAAACATTTC
CATAAAGGCTTTTTTACCCAACATGCAGTTCAAGTTTTCAATTCCTATATTCAGTGCCAC
CTAGCTGCTCCAGATGGCACAAGAAATTTGACTGCCAATGGTGTGGCCTCTCGTGAGGAG
GAAGAAATAAGTGAACTTCAAGAGGATGATCGAGACCAGTTTTCTGATCAACTGGCCAGT
GTAGGAATGCTAGGAAGAATTGCTGCAGAACACTGTATACCTCTTCTGACAAGTTTATTA
GAAGAAAGAGTAACAAGACTCCATGGTCAGTTACAACGACATCAGCAACAGTTACTTGCT
TCACCGGGTTCAAGCACTGTTGACAACAAAATGCTTGATGATCTCTATGAAGATATTCAC
TGGCTTATTTTAGTTACAGGCTACCTCTTAGCTGATGATACTCAGGGAGAGACTCCGCTA
ATACCTCCAGAAATAATGGAATATTCCATTAAGCATTCATCTGAAGTTGACATTAATACA
ACACTTCAAATTTTGGGATCTCCAGGAGAAAAGGCTTCTTCCATCCCAGGGTACAACAGA
ACAGATTCTGTGATTAGGCTGTTGTCTGCCATTCTCAGAGTTTCAGAAGTTGAATCTCGA
GCAATAAGAGCAGATCTCACTCATCTACTAAGTCCCCAGATGGGCAAAGATATTGTTTGG
TTTTTAAAACGCTGGGCAAAGACTTATCTCCTGGTGGATGAAAAACTGTATGATCAGATA
AGTCTGCCATTCAGTACAGCGTTCGGAGCAGATACAGAGGGTTCTCAGTGGATAATTGGC
TACCTCTTACAAAAAGTCATCAGTAACCTCTCAGTCTGGAGTAGTGAGCAGGACCTTGCA
AATGACACTGTGCAGCTCCTTGTCACTTTGGTGGAAAGAAGAGAAAGGGCAAACTTAGTA
ATTCAATGTGAGAACTGGTGGAATTTAGCTAAGCAGTTTGCAAGCCGAAGCCCACCTCTT
AATTTCTTGTCAAGTCCTGTGCAGAGGACATTGATGAAGGCTCTAGTCTTAGGAGGTTTT
GCACATATGGACACAGAAACCAAACAGCAGTATTGGACAGAGGTTCTTCAGCCACTTCAG
CAGCGATTCTTAAGAGTGATAAACCAAGAAAACTTCCAGCAGATGTGTCAGCAAGAGGAA
GTCAAGCAGGAAATCACTGCCACACTAGAGGCCCTGTGTGGCATTGCTGAGGCTACCCAG
ATTGACAACGTAGCAATCCTGTTTAATTTTTTAATGGACTTCCTTACCAATTGCATTGGA
TTGATGGAAGTTTACAAGAATACCCCAGAGACTGTCAATCTCATTATAGAAGTTTTTGTT
GAAGTTGCACATAAACAGATATGCTATCTTGGAGAGTCCAAAGCTATGAACTTATATGAA
GCCTGCCTTACTTTGTTGCAAGTGTATTCTAAGAATAATTTAGGGCGGCAAAGAATAGAT
GTTACAGCAGAAGAAGAGCAATACCAAGACCTGCTTCTCATTATGGAACTTCTTACTAAC
CTGCTGTCAAAAGAATTCATAGATTTCAGTGATACAGATGAAGTGTTTAGAGGACATGAG
CCAGGTCAAGCAGCAAACAGATCTGTGTCAGCAGCGGATGTTGTGTTGTATGGAGTAAAC
CTAATTCTGCCCTTGATGTCACAGGATCTCTTGAAGTTTCCAACCCTTTGTAATCAGTAC
TACAAATTAATCACATTTATCTGTGAGATTTTTCCTGAAAAAATACCACAGCTTCCTGAG
GATCTGTTTAAAAGTCTGATGTACTCCCTAGAATTAGGAATGACATCAATGAGTTCGGAG
GTTTGCCAGCTTTGCCTGGAGGCCTTGACACCGTTAGCTGAACAGTGTGCAAAAGCACAA
GAAACAGACTCACCACTTTTTCTAGCAACACGGCACTTTCTTAAGCTGGTTTTTGATATG
CTGGTTTTGCAAAAGCACAACACAGAGATGACCACTGCGGCTGGCGAAGCTTTCTACACG
TTGGTGTGTTTGCACCAGGCTGAATATTCTGAACTGGTCGAAACATTACTATCAAGTCAG
CAAGACCCAGTTATTTACCAGAGATTAGCAGATGCCTTCAACAAGCTCACTGCAAGCAGC
ACTCCTCCTACGCTGGATCGGAAGCAGAAGATGGCCTTCTTAAAGAGTTTAGAAGAATTT
ATGGCAAATGTTGGTGGTCTCCTTTGTGTAAAATAA
Protein Properties
Number of Residues 1151
Molecular Weight 130138.1
Theoretical pI 4.69
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Exportin-4
MMAAALGPPEVIAQLENAAKVLMAPPSMVNNEQRQHAEHIFLSFRKSKSPFAVCKHILET
SKVDYVLFQAATAIMEAVVREWILLEKGSIESLRTFLLTYVLQRPNLQKYVREQILLAVA
VIVKRGSLDKSIDCKSIFHEVSQLISSGNPTVQTLACSILTALLSEFSSSSKTSNIGLSM
EFHGNCKRVFQEEDLRQIFMLTVEVLQEFSRRENLNAQMSSVFQRYLALANQVLSWNFLP
PNLGRHYIAMFESSQNVLLKPTESWRETLLDSRVMELFFTVHRKIREDSDMAQDSLQCLA
QLASLHGPIFPDEGSQVDYLAHFIEGLLNTINGIEIEDSEAVGISSIISNLITVFPRNVL
TAIPSELFSSFVNCLTHLTCSFGRSAALEEVLDKDDMVYMEAYDKLLESWLTLVQDDKHF
HKGFFTQHAVQVFNSYIQCHLAAPDGTRNLTANGVASREEEEISELQEDDRDQFSDQLAS
VGMLGRIAAEHCIPLLTSLLEERVTRLHGQLQRHQQQLLASPGSSTVDNKMLDDLYEDIH
WLILVTGYLLADDTQGETPLIPPEIMEYSIKHSSEVDINTTLQILGSPGEKASSIPGYNR
TDSVIRLLSAILRVSEVESRAIRADLTHLLSPQMGKDIVWFLKRWAKTYLLVDEKLYDQI
SLPFSTAFGADTEGSQWIIGYLLQKVISNLSVWSSEQDLANDTVQLLVTLVERRERANLV
IQCENWWNLAKQFASRSPPLNFLSSPVQRTLMKALVLGGFAHMDTETKQQYWTEVLQPLQ
QRFLRVINQENFQQMCQQEEVKQEITATLEALCGIAEATQIDNVAILFNFLMDFLTNCIG
LMEVYKNTPETVNLIIEVFVEVAHKQICYLGESKAMNLYEACLTLLQVYSKNNLGRQRID
VTAEEEQYQDLLLIMELLTNLLSKEFIDFSDTDEVFRGHEPGQAANRSVSAADVVLYGVN
LILPLMSQDLLKFPTLCNQYYKLITFICEIFPEKIPQLPEDLFKSLMYSLELGMTSMSSE
VCQLCLEALTPLAEQCAKAQETDSPLFLATRHFLKLVFDMLVLQKHNTEMTTAAGEAFYT
LVCLHQAEYSELVETLLSSQQDPVIYQRLADAFNKLTASSTPPTLDRKQKMAFLKSLEEF
MANVGGLLCVK
GenBank ID Protein 148886661
UniProtKB/Swiss-Prot ID Q9C0E2
UniProtKB/Swiss-Prot Entry Name XPO4_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_022459.4
GeneCard ID XPO4
GenAtlas ID XPO4
HGNC ID HGNC:17796
References
General References
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