Showing Protein Exportin-7 (HMDBP08621)
Identification | |||||||||||
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HMDB Protein ID | HMDBP08621 | ||||||||||
Secondary Accession Numbers |
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Name | Exportin-7 | ||||||||||
Synonyms |
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Gene Name | XPO7 | ||||||||||
Protein Type | Unknown | ||||||||||
Biological Properties | |||||||||||
General Function | Involved in binding | ||||||||||
Specific Function | Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus | ||||||||||
Pathways | Not Available | ||||||||||
Reactions | Not Available | ||||||||||
GO Classification |
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Cellular Location |
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Gene Properties | |||||||||||
Chromosome Location | Chromosome:8 | ||||||||||
Locus | 8p21 | ||||||||||
SNPs | XPO7 | ||||||||||
Gene Sequence |
>3264 bp ATGGCGGATCATGTGCAGAGCCTGGCCCAACTAGAGAATCTGTGCAAACAGCTGTATGAA ACCACAGACACAACCACTCGACTCCAGGCAGAGAAAGCCTTGGTTGAATTTACCAACAGC CCTGATTGCCTGAGCAAGTGCCAGCTACTCCTCGAAAGAGGAAGTTCCTCTTACTCCCAG TTACTGGCAGCTACATGCCTTACCAAGCTTGTATCACGCACAAACAACCCCCTACCATTG GAACAGCGAATAGATATTCGGAACTATGTGCTCAACTACCTTGCCACTCGGCCGAAGTTG GCTACTTTCGTGACACAAGCACTTATTCAGTTATATGCCAGAATCACAAAACTGGGCTGG TTTGACTGTCAGAAGGATGACTATGTCTTCAGAAATGCAATCACAGACGTCACAAGGTTT TTACAGGATAGTGTTGAATACTGCATCATTGGTGTCACAATTTTATCTCAGCTAACCAAT GAAATTAATCAAGCAGACACCACCCATCCTTTAACCAAGCACAGAAAAATAGCCTCTTCT TTTCGCGATTCATCATTATTTGATATCTTCACACTTTCCTGCAATTTACTAAAACAGGCT TCAGGAAAGAATCTAAACTTGAATGATGAAAGTCAGCATGGCTTGCTCATGCAACTGCTC AAGCTCACTCATAACTGCCTCAACTTTGACTTCATCGGCACTTCCACTGATGAGTCCTCA GACGACCTGTGTACAGTGCAGATTCCCACCAGCTGGAGATCAGCCTTCTTAGATTCTTCA ACCTTGCAGCTGTTTTTTGACCTGTATCATTCCATCCCTCCTTCATTTTCACCTCTGGTA TTATCCTGCTTGGTACAGATCGCTTCAGTCAGAAGATCCCTGTTTAACAATGCAGAGAGG GCCAAGTTTCTCTCTCATCTTGTTGATGGTGTTAAACGAATACTGGAAAACCCACAGAGT TTATCAGACCCAAACAATTACCATGAGTTTTGCAGACTACTGGCCCGATTGAAGAGTAAC TATCAACTGGGAGAATTGGTAAAGGTGGAAAACTACCCTGAGGTCATCCGATTGATAGCC AACTTCACAGTGACCAGCCTACAGCACTGGGAATTTGCTCCAAATAGTGTGCACTATCTT CTGAGCCTGTGGCAGCGGCTGGCAGCCTCTGTGCCGTATGTCAAAGCCACAGAGCCCCAC ATGCTGGAAACTTACACTCCTGAGGTCACCAAAGCCTACATCACATCCCGGTTGGAATCT GTGCACATCATACTGAGAGATGGCCTGGAAGATCCCCTGGAGGATACGGGGCTGGTCCAG CAGCAGTTGGACCAGCTGTCCACCATTGGGCGTTGTGAATATGAGAAGACGTGTGCACTC CTCGTGCAGTTGTTTGACCAGTCGGCCCAGTCGTACCAGGAGCTGCTACAGAGCGCCAGC GCAAGCCCAATGGACATTGCAGTGCAGGAGGGAAGGCTGACATGGCTGGTTTACATTATT GGAGCAGTGATCGGTGGCCGGGTTTCTTTTGCCAGCACTGATGAGCAAGACGCCATGGAT GGTGAGCTTGTCTGTCGGGTGCTCCAGCTGATGAACCTAACAGATTCTCGTTTGGCCCAG GCGGGTAATGAGAAGCTAGAGTTGGCCATGCTGAGCTTTTTTGAACAGTTTCGTAAGATC TACATTGGGGACCAAGTGCAGAAATCCTCTAAGCTGTACCGCCGACTCTCAGAAGTTCTG GGCTTGAATGATGAGACCATGGTCCTAAGCGTCTTCATAGGAAAAATCATCACCAACTTG AAGTACTGGGGCCGTTGTGAACCAATCACCTCCAAGACACTACAGCTTCTCAATGACCTG TCCATTGGGTACAGTAGCGTAAGGAAGCTAGTGAAGCTTAGTGCGGTACAGTTCATGCTG AACAATCACACGAGCGAGCACTTTTCATTTTTGGGTATTAACAATCAGTCCAACCTGACA GACATGCGGTGTCGGACTACCTTCTACACAGCACTTGGGCGTCTCCTCATGGTGGATTTA GGAGAGGATGAAGATCAGTATGAGCAGTTCATGCTGCCACTCACAGCAGCATTTGAGGCT GTGGCCCAGATGTTTAGCACCAATAGTTTCAACGAGCAGGAGGCAAAGCGAACTCTAGTT GGCCTAGTAAGAGACCTGAGAGGGATCGCTTTCGCTTTCAATGCCAAGACCAGCTTCATG ATGCTCTTTGAATGGATATATCCATCCTATATGCCAATTCTCCAACGGGCAATTGAGCTC TGGTACCATGATCCAGCCTGTACTACACCTGTACTCAAGTTGATGGCTGAATTGGTTCAT AATAGGTCCCAGCGACTCCAGTTTGATGTCTCTTCCCCCAATGGCATCTTACTCTTCCGA GAAACCAGCAAGATGATAACAATGTATGGCAATCGCATCCTGACACTAGGAGAGGTCCCA AAGGATCAGGTCTATGCTCTGAAGCTCAAGGGCATCTCCATCTGCTTCTCCATGCTGAAG GCTGCTCTCAGTGGGAGTTACGTCAATTTCGGAGTCTTTCGTCTCTATGGAGACGATGCC CTGGACAATGCTCTGCAGACCTTCATCAAGCTGCTCCTCTCTATTCCTCACAGTGATCTC TTGGATTACCCCAAGCTCAGCCAGTCTTATTATTCACTACTGGAAGTCCTGACCCAGGAC CATATGAACTTTATTGCAAGCCTGGAACCTCACGTCATCATGTATATTCTCTCTTCCATT TCTGAAGGACTTACTGCACTTGACACCATGGTATGCACAGGCTGCTGCTCCTGCCTGGAC CACATTGTGACATACCTCTTCAAGCAGCTGTCACGTAGCACCAAGAAGAGGACCACACCC CTGAACCAGGAGAGCGACCGCTTTCTGCACATCATGCAGCAGCATCCAGAGATGATCCAG CAGATGCTGTCCACGGTGCTGAACATCATCATCTTTGAAGACTGTAGGAACCAGTGGTCT ATGTCCCGACCACTACTTGGCTTGATATTGCTTAATGAAAAGTATTTTTCTGACCTAAGA AACAGTATTGTGAACAGCCAGCCACCGGAGAAGCAGCAGGCCATGCACCTGTGTTTTGAG AACCTGATGGAAGGCATCGAGCGAAATCTTCTTACGAAAAACAGAGACAGGTTCACCCAG AACCTGTCAGCATTCCGTCGAGAAGTCAACGACTCAATGAAGAATTCCACTTATGGCGTG AATAGCAATGACATGATGAGCTGA |
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Protein Properties | |||||||||||
Number of Residues | 1087 | ||||||||||
Molecular Weight | 123906.1 | ||||||||||
Theoretical pI | 6.27 | ||||||||||
Pfam Domain Function |
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Signals |
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Transmembrane Regions |
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Protein Sequence |
>Exportin-7 MADHVQSLAQLENLCKQLYETTDTTTRLQAEKALVEFTNSPDCLSKCQLLLERGSSSYSQ LLAATCLTKLVSRTNNPLPLEQRIDIRNYVLNYLATRPKLATFVTQALIQLYARITKLGW FDCQKDDYVFRNAITDVTRFLQDSVEYCIIGVTILSQLTNEINQADTTHPLTKHRKIASS FRDSSLFDIFTLSCNLLKQASGKNLNLNDESQHGLLMQLLKLTHNCLNFDFIGTSTDESS DDLCTVQIPTSWRSAFLDSSTLQLFFDLYHSIPPSFSPLVLSCLVQIASVRRSLFNNAER AKFLSHLVDGVKRILENPQSLSDPNNYHEFCRLLARLKSNYQLGELVKVENYPEVIRLIA NFTVTSLQHWEFAPNSVHYLLSLWQRLAASVPYVKATEPHMLETYTPEVTKAYITSRLES VHIILRDGLEDPLEDTGLVQQQLDQLSTIGRCEYEKTCALLVQLFDQSAQSYQELLQSAS ASPMDIAVQEGRLTWLVYIIGAVIGGRVSFASTDEQDAMDGELVCRVLQLMNLTDSRLAQ AGNEKLELAMLSFFEQFRKIYIGDQVQKSSKLYRRLSEVLGLNDETMVLSVFIGKIITNL KYWGRCEPITSKTLQLLNDLSIGYSSVRKLVKLSAVQFMLNNHTSEHFSFLGINNQSNLT DMRCRTTFYTALGRLLMVDLGEDEDQYEQFMLPLTAAFEAVAQMFSTNSFNEQEAKRTLV GLVRDLRGIAFAFNAKTSFMMLFEWIYPSYMPILQRAIELWYHDPACTTPVLKLMAELVH NRSQRLQFDVSSPNGILLFRETSKMITMYGNRILTLGEVPKDQVYALKLKGISICFSMLK AALSGSYVNFGVFRLYGDDALDNALQTFIKLLLSIPHSDLLDYPKLSQSYYSLLEVLTQD HMNFIASLEPHVIMYILSSISEGLTALDTMVCTGCCSCLDHIVTYLFKQLSRSTKKRTTP LNQESDRFLHIMQQHPEMIQQMLSTVLNIIIFEDCRNQWSMSRPLLGLILLNEKYFSDLR NSIVNSQPPEKQQAMHLCFENLMEGIERNLLTKNRDRFTQNLSAFRREVNDSMKNSTYGV NSNDMMS |
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External Links | |||||||||||
GenBank ID Protein | 154448892 | ||||||||||
UniProtKB/Swiss-Prot ID | Q9UIA9 | ||||||||||
UniProtKB/Swiss-Prot Entry Name | XPO7_HUMAN | ||||||||||
PDB IDs | Not Available | ||||||||||
GenBank Gene ID | NM_015024.4 | ||||||||||
GeneCard ID | XPO7 | ||||||||||
GenAtlas ID | XPO7 | ||||||||||
HGNC ID | HGNC:14108 | ||||||||||
References | |||||||||||
General References |
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