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Showing Protein Fatty acid desaturase 3 (HMDBP08647)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP08647
Secondary Accession Numbers
  • 14366
Name Fatty acid desaturase 3
Synonyms
  1. Cytochrome b5-related protein
Gene Name FADS3
Protein Type Unknown
Biological Properties
General Function Involved in heme binding
Specific Function Not Available
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
transition metal ion binding
oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
iron ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
heme binding
oxidoreductase activity
Process
metabolic process
primary metabolic process
cellular metabolic process
organic acid metabolic process
oxoacid metabolic process
carboxylic acid metabolic process
monocarboxylic acid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
oxidation reduction
lipid metabolic process
Cellular Location
  1. Endoplasmic reticulum membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location Chromosome:1
Locus 11q12-q13.1
SNPs FADS3
Gene Sequence 
>1338 bp
ATGGGCGGCGTCGGGGAGCCGGGACCGCGGGAGGGACCCGCGCAGCCGGGGGCACCGCTG
CCCACCTTCTGCTGGGAGCAGATCCGCGCGCACGACCAGCCCGGCGACAAGTGGCTGGTC
ATCGAGCGCCGCGTCTACGACATCAGCCGCTGGGCACAGCGGCACCCAGGGGGCAGCCGC
CTCATCGGCCACCACGGCGCTGAGGACGCCACGGATGCCTTCCGTGCCTTCCATCAAGAT
CTCAATTTTGTGCGCAAGTTCCTACAGCCCCTGTTGATTGGAGAGCTGGCTCCGGAAGAA
CCCAGCCAGGATGGACCCCTGAATGCGCAGCTGGTCGAGGACTTCCGAGCCCTGCACCAG
GCAGCCGAGGACATGAAGCTGTTTGATGCCAGTCCCACCTTCTTTGCTTTCCTACTGGGC
CACATCCTGGCCATGGAGGTGCTGGCCTGGCTCCTTATCTACCTCCTGGGTCCTGGCTGG
GTGCCCAGTGCCCTGGCCGCCTTCATCCTGGCCATCTCTCAGGCTCAGTCCTGGTGTCTG
CAGCATGACCTGGGCCATGCCTCCATCTTCAAGAAGTCCTGGTGGAACCACGTGGCCCAG
AAGTTCGTGATGGGGCAGCTAAAGGGCTTCTCCGCCCACTGGTGGAACTTCCGCCACTTC
CAGCACCACGCCAAGCCCAACATCTTCCACAAAGACCCAGACGTGACGGTGGCGCCCGTC
TTCCTCCTGGGGGAGTCATCCGTCGAGTATGGCAAGAAGAAACGCAGATACCTACCCTAC
AACCAGCAGCACCTGTACTTCTTCCTGATCGGCCCGCCGCTGCTCACCCTGGTGAACTTT
GAAGTGGAAAATCTGGCGTACATGCTGGTGTGCATGCAGTGGGCGGATTTGCTCTGGGCC
GCCAGCTTCTATGCCCGCTTCTTCTTATCCTACCTCCCCTTCTACGGCGTCCCTGGGGTG
CTGCTCTTCTTTGTTGCTGTCAGGGTCCTGGAAAGCCACTGGTTCGTGTGGATCACACAG
ATGAACCACATCCCCAAGGAGATCGGCCACGAGAAGCACCGGGACTGGGTCAGCTCTCAG
CTGGCAGCCACCTGCAACGTGGAGCCCTCACTTTTCACCAACTGGTTCAGCGGGCACCTC
AACTTCCAGATCGAGCACCACCTCTTCCCCAGGATGCCGAGACACAACTACAGCCGGGTG
GCCCCGCTGGTCAAGTCGCTGTGTGCCAAGCACGGCCTCAGCTACGAAGTGAAGCCCTTC
CTCACCGCGCTGGTGGACATCGTCAGGTCCCTGAAGAAGTCTGGTGACATCTGGCTGGAC
GCCTACCTCCATCAGTGA
Protein Properties
Number of Residues 445
Molecular Weight 51144.6
Theoretical pI 7.84
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 134-154
  • 160-180
  • 264-284
  • 307-327
Protein Sequence 
>Fatty acid desaturase 3
MGGVGEPGPREGPAQPGAPLPTFCWEQIRAHDQPGDKWLVIERRVYDISRWAQRHPGGSR
LIGHHGAEDATDAFRAFHQDLNFVRKFLQPLLIGELAPEEPSQDGPLNAQLVEDFRALHQ
AAEDMKLFDASPTFFAFLLGHILAMEVLAWLLIYLLGPGWVPSALAAFILAISQAQSWCL
QHDLGHASIFKKSWWNHVAQKFVMGQLKGFSAHWWNFRHFQHHAKPNIFHKDPDVTVAPV
FLLGESSVEYGKKKRRYLPYNQQHLYFFLIGPPLLTLVNFEVENLAYMLVCMQWADLLWA
ASFYARFFLSYLPFYGVPGVLLFFVAVRVLESHWFVWITQMNHIPKEIGHEKHRDWVSSQ
LAATCNVEPSLFTNWFSGHLNFQIEHHLFPRMPRHNYSRVAPLVKSLCAKHGLSYEVKPF
LTALVDIVRSLKKSGDIWLDAYLHQ
GenBank ID Protein 10798853
UniProtKB/Swiss-Prot ID Q9Y5Q0
UniProtKB/Swiss-Prot Entry Name FADS3_HUMAN
PDB IDs Not Available
GenBank Gene ID AF084560
GeneCard ID FADS3
GenAtlas ID FADS3
HGNC ID HGNC:3576
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [PubMed:16554811 ]
  3. Marquardt A, Stohr H, White K, Weber BH: cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. Genomics. 2000 Jun 1;66(2):175-83. [PubMed:10860662 ]