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Identification
HMDB Protein ID HMDBP08650
Secondary Accession Numbers
  • 14369
Name Hemoglobin subunit zeta
Synonyms
  1. HBAZ
  2. Hemoglobin zeta chain
  3. Zeta-globin
Gene Name HBZ
Protein Type Unknown
Biological Properties
General Function Involved in iron ion binding
Specific Function The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin, synthesized primarily in the yolk sac
Pathways Not Available
Reactions Not Available
GO Classification
Component
macromolecular complex
protein complex
hemoglobin complex
Function
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
iron ion binding
heme binding
oxygen binding
Process
establishment of localization
transport
gas transport
oxygen transport
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:1
Locus 16p13.3
SNPs HBZ
Gene Sequence
>429 bp
ATGTCTCTGACCAAGACTGAGAGGACCATCATTGTGTCCATGTGGGCCAAGATCTCCACG
CAGGCCGACACCATCGGCACCGAGACTCTGGAGAGGCTCTTCCTCAGCCACCCGCAGACC
AAGACCTACTTCCCGCACTTCGACCTGCACCCGGGGTCCGCGCAGTTGCGCGCGCACGGC
TCCAAGGTGGTGGCCGCCGTGGGCGACGCGGTGAAGAGCATCGACGACATCGGCGGCGCC
CTGTCCAAGCTGAGCGAGCTGCACGCCTACATCCTGCGCGTGGACCCGGTCAACTTCAAG
CTCCTGTCCCACTGCCTGCTGGTCACCCTGGCCGCGCGCTTCCCCGCCGACTTCACGGCC
GAGGCCCACGCCGCCTGGGACAAGTTCCTATCGGTCGTATCCTCTGTCCTGACCGAGAAG
TACCGCTGA
Protein Properties
Number of Residues 142
Molecular Weight 15636.8
Theoretical pI 8.51
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Hemoglobin subunit zeta
MSLTKTERTIIVSMWAKISTQADTIGTETLERLFLSHPQTKTYFPHFDLHPGSAQLRAHG
SKVVAAVGDAVKSIDDIGGALSKLSELHAYILRVDPVNFKLLSHCLLVTLAARFPADFTA
EAHAAWDKFLSVVSSVLTEKYR
GenBank ID Protein 340392
UniProtKB/Swiss-Prot ID P02008
UniProtKB/Swiss-Prot Entry Name HBAZ_HUMAN
PDB IDs
GenBank Gene ID M24173
GeneCard ID HBZ
GenAtlas ID HBZ
HGNC ID HGNC:4835
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR: Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. Hum Mol Genet. 2001 Feb 15;10(4):339-52. [PubMed:11157797 ]
  3. Proudfoot NJ, Gil A, Maniatis T: The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene. Cell. 1982 Dec;31(3 Pt 2):553-63. [PubMed:6297773 ]
  4. Cohen-Solal MM, Authier B, deRiel JK, Murnane MJ, Forget BG: Cloning and nucleotide sequence analysis of human embryonic zeta-globin cDNA. DNA. 1982;1(4):355-63. [PubMed:6963223 ]
  5. Flint J, Thomas K, Micklem G, Raynham H, Clark K, Doggett NA, King A, Higgs DR: The relationship between chromosome structure and function at a human telomeric region. Nat Genet. 1997 Mar;15(3):252-7. [PubMed:9054936 ]
  6. Aschauer H, Sanguansermsri T, Braunitzer G: [Human embryonic haemoglobins. The primary structure of the zeta chains (author's transl)]. Hoppe Seylers Z Physiol Chem. 1981 Aug;362(8):1159-62. [PubMed:6179844 ]
  7. Clegg JB, Gagnon J: Structure of the zeta chain of human embryonic hemoglobin. Proc Natl Acad Sci U S A. 1981 Oct;78(10):6076-80. [PubMed:6171809 ]
  8. Aschauer H, Schafer W, Sanguansermsri T, Braunitzer G: [Human embryonic haemoglobins. Ac-Ser-Leu-Thr-is the N-terminal sequence of the zeta-chains (author's transl)]. Hoppe Seylers Z Physiol Chem. 1981 Dec;362(12):1657-9. [PubMed:6172357 ]