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Identification
HMDB Protein ID HMDBP08659
Secondary Accession Numbers
  • 14378
Name Mitoferrin-2
Synonyms
  1. MRS3/4
  2. Mitochondrial RNA-splicing protein 3/4 homolog
  3. Mitochondrial iron transporter 2
  4. Solute carrier family 25 member 28
  5. hMRS3/4
Gene Name SLC25A28
Protein Type Unknown
Biological Properties
General Function Involved in binding
Specific Function Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
Function
binding
Process
establishment of localization
transport
transmembrane transport
Cellular Location
  1. Mitochondrion inner membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location Chromosome:1
Locus 10q24.2
SNPs SLC25A28
Gene Sequence
>1095 bp
ATGGAGTTGGAGGGGCGGGGTGCTGGCGGTGTGGCGGGGGGGCCGGCGGCAGGGCCCGGG
CGGAGCCCCGGGGAGTCGGCGCTGCTGGACGGGTGGCTGCAGCGGGGCGTGGGCCGGGGG
GCCGGCGGCGGGGAGGCCGGGGCCTGCAGGCCCCCGGTACGACAAGATCCGGACTCCGGC
CCGGACTACGAGGCGCTGCCGGCTGGAGCCACTGTCACCACGCACATGGTGGCAGGCGCC
GTGGCAGGGATCCTGGAGCACTGCGTGATGTACCCCATCGACTGCGTCAAGACCCGGATG
CAGAGTCTACAGCCTGACCCAGCTGCCCGCTATCGCAATGTGTTGGAGGCCCTCTGGAGG
ATTATAAGAACGGAGGGCCTATGGAGGCCCATGAGGGGGCTGAACGTCACAGCAACAGGC
GCAGGGCCTGCCCACGCCCTTTATTTTGCCTGCTACGAAAAGTTAAAAAAGACATTGAGT
GATGTAATCCACCCTGGGGGCAATAGCCATATTGCCAATGGTGCGGCCGGGTGTGTGGCA
ACATTACTTCATGATGCAGCCATGAACCCTGCGGAAGTGGTCAAGCAGAGGATGCAGATG
TACAACTCACCATACCACCGGGTGACAGACTGTGTACGGGCAGTGTGGCAAAATGAAGGG
GCCGGGGCCTTTTACCGCAGCTACACCACCCAGCTGACCATGAACGTTCCTTTCCAAGCC
ATTCACTTCATGACCTATGAATTCCTGCAGGAGCACTTTAACCCCCAGAGACGGTACAAC
CCAAGCTCCCACGTCCTCTCTGGAGCTTGCGCAGGAGCTGTAGCTGCCGCAGCCACAACC
CCACTGGACGTTTGCAAAACACTGCTCAACACCCAGGAGTCCTTGGCTTTGAACTCACAC
ATTACAGGACATATCACAGGCATGGCTAGTGCCTTCAGGACGGTATATCAAGTAGGTGGG
GTGACCGCCTATTTCCGAGGGGTGCAGGCCAGAGTAATTTACCAGATCCCCTCCACAGCC
ATCGCATGGTCTGTGTATGAGTTCTTCAAATACCTAATCACTAAAAGGCAAGAAGAGTGG
AGGGCTGGCAAGTGA
Protein Properties
Number of Residues 364
Molecular Weight 39271.5
Theoretical pI 8.69
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 72-91
  • 133-152
  • 170-189
  • 227-246
  • 261-280
  • 327-346
Protein Sequence
>Mitoferrin-2
MELEGRGAGGVAGGPAAGPGRSPGESALLDGWLQRGVGRGAGGGEAGACRPPVRQDPDSG
PDYEALPAGATVTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWR
IIRTEGLWRPMRGLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGGNSHIANGAAGCVA
TLLHDAAMNPAEVVKQRMQMYNSPYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQA
IHFMTYEFLQEHFNPQRRYNPSSHVLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSH
ITGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFKYLITKRQEEW
RAGK
GenBank ID Protein 149274643
UniProtKB/Swiss-Prot ID Q96A46
UniProtKB/Swiss-Prot Entry Name MFRN2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_031212.3
GeneCard ID SLC25A28
GenAtlas ID SLC25A28
HGNC ID HGNC:23472
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J: The DNA sequence and comparative analysis of human chromosome 10. Nature. 2004 May 27;429(6990):375-81. [PubMed:15164054 ]
  3. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  4. Li FY, Nikali K, Gregan J, Leibiger I, Leibiger B, Schweyen R, Larsson C, Suomalainen A: Characterization of a novel human putative mitochondrial transporter homologous to the yeast mitochondrial RNA splicing proteins 3 and 4. FEBS Lett. 2001 Apr 6;494(1-2):79-84. [PubMed:11297739 ]