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Showing Protein Neudesin (HMDBP08660)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 metabolites
Identification
HMDB Protein ID HMDBP08660
Secondary Accession Numbers
  • 14379
Name Neudesin
Synonyms
  1. Cell immortalization-related protein 2
  2. Neuron-derived neurotrophic factor
  3. SPUF protein
  4. Secreted protein of unknown function
Gene Name NENF
Protein Type Unknown
Biological Properties
General Function Involved in heme binding
Specific Function Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on neuronal differentiation and may have a transient effect on neural cell proliferation in neural precursor cells. Neurotrophic activity is enhanced by binding to heme
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
iron ion binding
heme binding
Cellular Location
  1. Secreted
  2. extracellular space
Gene Properties
Chromosome Location Chromosome:1
Locus 1q32.3
SNPs NENF
Gene Sequence 
>519 bp
ATGGTGGGCCCCGCGCCGCGGCGGCGGCTGCGGCCGCTGGCAGCGCTGGCCCTGGTCCTG
GCGCTGGCCCCGGGGCTGCCCACAGCCCGGGCCGGGCAGACACCGCGCCCTGCCGAGCGG
GGGCCCCCAGTGCGGCTTTTCACCGAGGAGGAGCTGGCCCGCTATGGCGGGGAGGAGGAA
GATCAGCCCATCTACTTGGCAGTGAAGGGAGTGGTGTTTGATGTCACCTCCGGAAAGGAG
TTTTATGGACGAGGAGCCCCCTACAATGCCTTGACGGGGAAGGACTCCACTAGAGGGGTA
GCCAAGATGTCCTTGGATCCTGCAGACCTCACCCATGACACTACGGGTCTCACGGCCAAG
GAACTGGAGGCCCTGGATGAGGTCTTCACCAAAGTGTACAAAGCCAAATACCCCATCGTC
GGCTACACTGCCCGGAGAATTCTCAATGAGGATGGCAGCCCTAACCTGGACTTCAAGCCT
GAAGACCAGCCCCATTTTGACATCAAGGATGAGTTCTGA
Protein Properties
Number of Residues 172
Molecular Weight 18856.2
Theoretical pI 5.36
Pfam Domain Function
Signals
  • 1-31
Transmembrane Regions
  • None
Protein Sequence 
>Neudesin
MVGPAPRRRLRPLAALALVLALAPGLPTARAGQTPRPAERGPPVRLFTEEELARYGGEEE
DQPIYLAVKGVVFDVTSGKEFYGRGAPYNALTGKDSTRGVAKMSLDPADLTHDTTGLTAK
ELEALDEVFTKVYKAKYPIVGYTARRILNEDGSPNLDFKPEDQPHFDIKDEF
GenBank ID Protein 55771070
UniProtKB/Swiss-Prot ID Q9UMX5
UniProtKB/Swiss-Prot Entry Name NENF_HUMAN
PDB IDs Not Available
GenBank Gene ID AB126219
GeneCard ID NENF
GenAtlas ID NENF
HGNC ID HGNC:30384
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [PubMed:19608861 ]
  3. Kimura I, Yoshioka M, Konishi M, Miyake A, Itoh N: Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity. J Neurosci Res. 2005 Feb 1;79(3):287-94. [PubMed:15605373 ]
  4. Ma L, Broomfield S, Lavery C, Lin SL, Xiao W, Bacchetti S: Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines. Oncogene. 1998 Sep 10;17(10):1321-6. [PubMed:9771976 ]
  5. Neubauer H, Clare SE, Kurek R, Fehm T, Wallwiener D, Sotlar K, Nordheim A, Wozny W, Schwall GP, Poznanovic S, Sastri C, Hunzinger C, Stegmann W, Schrattenholz A, Cahill MA: Breast cancer proteomics by laser capture microdissection, sample pooling, 54-cm IPG IEF, and differential iodine radioisotope detection. Electrophoresis. 2006 May;27(9):1840-52. [PubMed:16645950 ]