Hmdb loader
Survey

Showing Protein Nuclear factor erythroid 2-related factor 1 (HMDBP08661)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP08661
Secondary Accession Numbers
  • 14380
Name Nuclear factor erythroid 2-related factor 1
Synonyms
  1. Locus control region-factor 1
  2. NF-E2-related factor 1
  3. NFE2-related factor 1
  4. Nuclear factor, erythroid derived 2, like 1
  5. TCF-11
  6. Transcription factor 11
  7. Transcription factor HBZ17
  8. Transcription factor LCR-F1
Gene Name NFE2L1
Protein Type Unknown
Biological Properties
General Function Involved in sequence-specific DNA binding transcription factor activity
Specific Function Activates erythroid-specific, globin gene expression
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
protein binding
nucleic acid binding
dna binding
protein dimerization activity
sequence-specific dna binding
sequence-specific dna binding transcription factor activity
Process
biological regulation
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
regulation of gene expression
regulation of transcription
regulation of transcription, dna-dependent
Cellular Location
  1. Nucleus
Gene Properties
Chromosome Location Chromosome:1
Locus 17q21.3
SNPs NFE2L1
Gene Sequence 
>2319 bp
ATGCTTTCTCTGAAGAAATACTTAACGGAAGGACTTCTCCAGTTCACCATTCTGCTGAGT
TTGATTGGGGTACGGGTGGACGTGGATACTTACCTGACCTCACAGCTTCCCCCACTCCGG
GAGATCATCCTGGGGCCCAGTTCTGCCTATACTCAGACCCAGTTCCACAACCTGAGGAAT
ACCTTGGATGGCTATGGTATCCACCCCAAGAGCATAGACCTGGACAATTACTTCACTGCC
CGGCGGCTCCTCAGTCAGGTGAGGGCCCTGGACAGGTTCCAGGTGCCAACCACTGAGGTA
AATGCCTGGCTGGTTCACCGAGACCCAGAGGGGTCTGTCTCTGGCAGTCAGCCCAACTCA
GGCCTCGCCCTCGAGAGTTCCAGTGGCCTCCAAGATGTGACAGGCCCAGACAACGGGGTG
CGAGAAAGCGAAACGGAGCAGGGATTCGGTGAAGATTTGGAGGATTTGGGGGCTGTAGCC
CCCCCAGTCAGTGGAGACTTAACCAAAGAGGACATAGATCTGATTGACATCCTTTGGCGA
CAGGATATTGATCTGGGGGCTGGGCGTGAGGTTTTTGACTATAGTCACCGCCAGAAGGAG
CAGGATGTGGAGAAGGAGCTGCGAGATGGAGGCGAGCAGGACACCTGGGCAGGCGAGGGC
GCGGAAGCTCTGGCACGGAACCTGCTAGTGGATGGAGAGACTGGGGAGAGCTTCCCTGCA
CAGGTGCCTAGTGGGGAGGACCAGACGGCCCTGTCCCTGGAAGAGTGCCTTAGGCTGCTG
GAAGCCACCTGCCCCTTTGGGGAGAATGCTGAGTTTCCAGCAGACATTTCCAGCATAACA
GAAGCAGTGCCTAGTGAGAGTGAGCCCCCTGCTCTTCAAAACAACCTCTTGTCTCCTCTT
CTGACCGGGACAGAGTCACCATTTGATTTGGAACAGCAGTGGCAAGATCTCATGTCCATC
ATGGAAATGCAGGCCATGGAAGTGAACACATCAGCAAGTGAAATCCTGTACAGTGCCCCT
CCTGGAGACCCACTGAGCACCAACTACAGCCTTGCCCCCAACACTCCCATCAATCAGAAT
GTCAGCCTGCATCAGGCGTCCCTGGGGGGCTGCAGCCAGGACTTCTTACTCTTCAGCCCC
GAGGTGGAAAGCCTGCCTGTGGCCAGTAGCTCCACGCTGCTCCCGTTGGCCCCCAGCAAT
TCTACCAGCCTCAACTCCACCTTCGGCTCCACCAACCTGACAGGGCTCTTCTTTCCACCC
CAGCTCAATGGCACAGCCAATGACACAGCAGGCCCAGAGCTGCCTGACCCTTTGGGGGGT
CTGTTAGATGAAGCTATGTTGGATGAGATCAGCCTTATGGACCTGGCCATTGAAGAAGGC
TTTAACCCTGTGCAGGCCTCCCAGCTGGAGGAGGAATTTGACTCTGACTCAGGCCTTTCC
TTAGACTCGAGCCATAGCCCTTCTTCCCTAAGCAGCTCTGAAGGCAGTTCTTCCTCTTCT
TCCTCCTCCTCTTCCTCTTCTTCCTCTGCTTCTTCCTCTGCCTCTTCCTCCTTTTCTGAG
GAAGGTGCGGTTGGCTACAGCTCTGACTCTGAGACCCTGGATCTGGAAGAGGCCGAGGGT
GCTGTGGGCTACCAGCCTGAGTATTCCAAGTTCTGCCGCATGAGCTACCAGGATCCAGCT
CAGCTCTCATGCCTGCCCTACCTGGAGCACGTGGGCCACAACCACACATACAACATGGCA
CCCAGTGCCCTGGACTCAGCCGACCTGCCACCACCCAGTGCCCTCAAGAAAGGCAGCAAG
GAGAAGCAGGCTGACTTCCTGGACAAGCAGATGAGCCGGGATGAGCACCGAGCCCGAGCC
ATGAAGATCCCTTTCACCAATGACAAAATCATCAACCTGCCTGTGGAGGAGTTCAATGAA
CTGCTGTCCAAATACCAGTTGAGTGAAGCCCAGCTGAGCCTCATCCGAGACATCCGGCGC
CGGGGCAAGAACAAGATGGCGGCGCAGAACTGCCGCAAGCGCAAGCTGGACACCATCCTG
AATCTGGAGCGTGATGTGGAGGACCTGCAGCGTGACAAAGCCCGGCTGCTGCGGGAGAAA
GTGGAGTTCCTGCGCTCCCTGCGACAGATGAAGCAGAAGGTCCAGAGCCTGTACCAGGAG
GTGTTTGGGCGGCTGCGAGATGAGAACGGACGACCCTACTCGCCCAGTCAGTATGCGCTC
CAGTACGCCGGGGACGGCAGTGTCCTCCTCATCCCCCGCACGATGGCCGACCAGCAGGCC
CGGCGGCAGGAGAGGAAGCCAAAGGACCGGAGAAAGTGA
Protein Properties
Number of Residues 772
Molecular Weight 84702.8
Theoretical pI 4.25
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence 
>Nuclear factor erythroid 2-related factor 1
MLSLKKYLTEGLLQFTILLSLIGVRVDVDTYLTSQLPPLREIILGPSSAYTQTQFHNLRN
TLDGYGIHPKSIDLDNYFTARRLLSQVRALDRFQVPTTEVNAWLVHRDPEGSVSGSQPNS
GLALESSSGLQDVTGPDNGVRESETEQGFGEDLEDLGAVAPPVSGDLTKEDIDLIDILWR
QDIDLGAGREVFDYSHRQKEQDVEKELRDGGEQDTWAGEGAEALARNLLVDGETGESFPA
QVPSGEDQTALSLEECLRLLEATCPFGENAEFPADISSITEAVPSESEPPALQNNLLSPL
LTGTESPFDLEQQWQDLMSIMEMQAMEVNTSASEILYSAPPGDPLSTNYSLAPNTPINQN
VSLHQASLGGCSQDFLLFSPEVESLPVASSSTLLPLAPSNSTSLNSTFGSTNLTGLFFPP
QLNGTANDTAGPELPDPLGGLLDEAMLDEISLMDLAIEEGFNPVQASQLEEEFDSDSGLS
LDSSHSPSSLSSSEGSSSSSSSSSSSSSSASSSASSSFSEEGAVGYSSDSETLDLEEAEG
AVGYQPEYSKFCRMSYQDPAQLSCLPYLEHVGHNHTYNMAPSALDSADLPPPSALKKGSK
EKQADFLDKQMSRDEHRARAMKIPFTNDKIINLPVEEFNELLSKYQLSEAQLSLIRDIRR
RGKNKMAAQNCRKRKLDTILNLERDVEDLQRDKARLLREKVEFLRSLRQMKQKVQSLYQE
VFGRLRDENGRPYSPSQYALQYAGDGSVLLIPRTMADQQARRQERKPKDRRK
GenBank ID Protein 4505379
UniProtKB/Swiss-Prot ID Q14494
UniProtKB/Swiss-Prot Entry Name NF2L1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_003204.2
GeneCard ID NFE2L1
GenAtlas ID NFE2L1
HGNC ID HGNC:7781
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Tang LY, Deng N, Wang LS, Dai J, Wang ZL, Jiang XS, Li SJ, Li L, Sheng QH, Wu DQ, Li L, Zeng R: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction. Mol Cell Proteomics. 2007 Nov;6(11):1952-67. Epub 2007 Aug 12. [PubMed:17693683 ]
  3. Chan JY, Han XL, Kan YW: Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11371-5. [PubMed:8248256 ]
  4. Luna L, Johnsen O, Skartlien AH, Pedeutour F, Turc-Carel C, Prydz H, Kolsto AB: Molecular cloning of a putative novel human bZIP transcription factor on chromosome 17q22. Genomics. 1994 Aug;22(3):553-62. [PubMed:8001966 ]
  5. Caterina JJ, Donze D, Sun CW, Ciavatta DJ, Townes TM: Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression. Nucleic Acids Res. 1994 Jun 25;22(12):2383-91. [PubMed:8036168 ]