| Identification |
|---|
| HMDB Protein ID
| HMDBP08663 |
| Secondary Accession Numbers
| |
| Name
| Nuclear respiratory factor 1 |
| Synonyms
|
- Alpha palindromic-binding protein
- Alpha-pal
- NRF-1
|
| Gene Name
| NRF1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in DNA binding |
| Specific Function
| Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Nucleus
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:7 |
| Locus
| 7q32 |
| SNPs
| NRF1 |
| Gene Sequence
|
>1512 bp
ATGGAGGAACACGGAGTGACCCAAACCGAACATATGGCTACCATAGAAGCACATGCAGTG
GCCCAGCAAGTGCAGCAGGTCCATGTGGCTACTTACACCGAGCATAGTATGCTGAGTGCT
GATGAAGACTCGCCTTCTTCGCCCGAGGACACCTCTTACGATGACTCAGATATACTCAAC
TCCACAGCAGCTGATGAGGTGACAGCTCATCTGGCAGCTGCAGGTCCTGTGGGAATGGCC
GCTGCTGCTGCTGTGGCAACAGGAAAGAAACGGAAACGGCCTCATGTATTTGAGTCTAAT
CCATCTATCCGGAAGAGGCAACAAACACGTTTGCTTCGGAAACTTCGAGCCACGTTAGAT
GAATATACTACTCGTGTGGGACAGCAAGCTATTGTCCTCTGTATCTCACCCTCCAAACCT
AACCCTGTCTTTAAAGTGTTTGGTGCAGCACCTTTGGAGAATGTGGTGCGTAAGTACAAG
AGCATGATCCTGGAAGACCTGGAGTCTGCTCTGGCAGAACACGCCCCTGCGCCACAGGAG
GTTAACTCAGAACTGCCGCCTCTCACCATCGACGGAATTCCAGTCTCTGTGGACAAAATG
ACCCAGGCCCAGCTTCGGGCATTTATCCCAGAGATGCTCAAGTACTCTACAGGTCGGGGA
AAACCAGGCTGGGGGAAAGAAAGCTGCAAGCCCATCTGGTGGCCTGAAGATATCCCCTGG
GCAAATGTCCGGAGTGATGTCCGCACAGAAGAGCAAAAGCAGAGGGTTTCATGGACCCAG
GCACTACGGACCATAGTTAAAAACTGTTATAAACAGCATGGGCGGGAAGACCTTTTGTAT
GCCTTTGAAGATCAGCAAACGCAAACACAGGCCACAGCCACACATAGTATAGCTCATCTT
GTACCATCACAGACTGTAGTCCAGACTTTTAGTAACCCTGATGGCACTGTCTCACTTATC
CAGGTTGGTACGGGGGCAACAGTAGCCACATTGGCTGATGCTTCAGAATTGCCAACCACG
GTCACCGTTGCCCAAGTGAATTATTCTGCCGTGGCTGATGGAGAGGTGGAACAAAATTGG
GCCACGTTACAGGGAGGTGAGATGACCATCCAGACGACGCAAGCATCAGAGGCCACCCAG
GCGGTGGCATCGTTGGCAGAGGCCGCAGTGGCAGCTTCTCAGGAGATGCAGCAGGGAGCT
ACAGTCACTATGGCGCTTAACAGCGAAGCTGCCGCCCATGCTGTCGCCACCCTGGCTGAG
GCCACCTTACAAGGTGGGGGACAGATCGTCTTGTCTGGGGAAACCGCAGCAGCCGTCGGA
GCACTTACTGGAGTCCAAGATGCTAATGGCCTGGTCCAGATCCCTGTGAGCATGTACCAG
ACTGTGGTGACCAGCCTCGCCCAGGGCAACGGACCAGTGCAGGTGGCCATGGCCCCTGTG
ACCACCAGGATATCAGACAGCGCAGTCACCATGGACGGCCAAGCTGTGGAGGTGGTGACA
TTGGAACAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 503 |
| Molecular Weight
| 53540.7 |
| Theoretical pI
| 4.69 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Nuclear respiratory factor 1
MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDSPSSPEDTSYDDSDILN
STAADEVTAHLAAAGPVGMAAAAAVATGKKRKRPHVFESNPSIRKRQQTRLLRKLRATLD
EYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLENVVRKYKSMILEDLESALAEHAPAPQE
VNSELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPW
ANVRSDVRTEEQKQRVSWTQALRTIVKNCYKQHGREDLLYAFEDQQTQTQATATHSIAHL
VPSQTVVQTFSNPDGTVSLIQVGTGATVATLADASELPTTVTVAQVNYSAVADGEVEQNW
ATLQGGEMTIQTTQASEATQAVASLAEAAVAASQEMQQGATVTMALNSEAAAHAVATLAE
ATLQGGGQIVLSGETAAAVGALTGVQDANGLVQIPVSMYQTVVTSLAQGNGPVQVAMAPV
TTRISDSAVTMDGQAVEVVTLEQ
|
| External Links |
|---|
| GenBank ID Protein
| 347960 |
| UniProtKB/Swiss-Prot ID
| Q16656 |
| UniProtKB/Swiss-Prot Entry Name
| NRF1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| L22454 |
| GeneCard ID
| NRF1 |
| GenAtlas ID
| NRF1 |
| HGNC ID
| HGNC:7996 |
| References |
|---|
| General References
| - Vercauteren K, Pasko RA, Gleyzer N, Marino VM, Scarpulla RC: PGC-1-related coactivator: immediate early expression and characterization of a CREB/NRF-1 binding domain associated with cytochrome c promoter occupancy and respiratory growth. Mol Cell Biol. 2006 Oct;26(20):7409-19. Epub 2006 Aug 14. [PubMed:16908542 ]
- Virbasius CA, Virbasius JV, Scarpulla RC: NRF-1, an activator involved in nuclear-mitochondrial interactions, utilizes a new DNA-binding domain conserved in a family of developmental regulators. Genes Dev. 1993 Dec;7(12A):2431-45. [PubMed:8253388 ]
- Efiok BJ, Chiorini JA, Safer B: A key transcription factor for eukaryotic initiation factor-2 alpha is strongly homologous to developmental transcription factors and may link metabolic genes to cellular growth and development. J Biol Chem. 1994 Jul 22;269(29):18921-30. [PubMed:8034649 ]
- Gopalakrishnan L, Scarpulla RC: Structure, expression, and chromosomal assignment of the human gene encoding nuclear respiratory factor 1. J Biol Chem. 1995 Jul 28;270(30):18019-25. [PubMed:7629110 ]
- Spelbrink JN, Van den Bogert C: The pre-mRNA of nuclear respiratory factor 1, a regulator of mitochondrial biogenesis, is alternatively spliced in human tissues and cell lines. Hum Mol Genet. 1995 Sep;4(9):1591-6. [PubMed:8541844 ]
- Gugneja S, Scarpulla RC: Serine phosphorylation within a concise amino-terminal domain in nuclear respiratory factor 1 enhances DNA binding. J Biol Chem. 1997 Jul 25;272(30):18732-9. [PubMed:9228045 ]
- Andersson U, Scarpulla RC: Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells. Mol Cell Biol. 2001 Jun;21(11):3738-49. [PubMed:11340167 ]
|
