Hmdb loader
Identification
HMDB Protein ID HMDBP08691
Secondary Accession Numbers
  • 14412
Name Sideroflexin-1
Synonyms
  1. TCC
  2. Tricarboxylate carrier protein
Gene Name SFXN1
Protein Type Unknown
Biological Properties
General Function Involved in cation transmembrane transporter activity
Specific Function Might be involved in the transport of a component required for iron utilization into or out of the mitochondria
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
Function
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
transporter activity
Process
establishment of localization
transport
transmembrane transport
ion transport
cation transport
Cellular Location
  1. Mitochondrion membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs SFXN1
Gene Sequence
>969 bp
ATGTCTGGAGAACTACCACCAAACATTAACATCAAGGAACCTCGATGGGATCAAAGCACT
TTCATTGGACGAGCCAATCATTTCTTCACTGTAACTGACCCCAGGAACATTCTGTTAACC
AACGAACAACTCGAGAGTGCGAGAAAAATAGTACATGATTACAGGCAAGGAATTGTTCCT
CCTGGTCTTACAGAAAATGAATTGTGGAGAGCAAAGTACATCTATGATTCAGCTTTTCAT
CCTGACACTGGTGAGAAGATGATTTTGATAGGAAGAATGTCAGCCCAGGTTCCCATGAAC
ATGACCATCACAGGTTGTATGATGACGTTTTACAGGACTACGCCGGCTGTGCTGTTCTGG
CAGTGGATTAACCAGTCCTTCAATGCCGTCGTCAATTACACCAACAGAAGTGGAGACGCA
CCCCTCACTGTCAATGAGTTGGGAACAGCTTACGTTTCTGCAACAACTGGTGCCGTAGCA
ACAGCTCTAGGACTCAATGCATTGACCAAGCATGTCTCACCACTGATAGGACGTTTTGTT
CCCTTTGCTGCCGTAGCTGCTGCTAATTGCATTAATATTCCATTAATGAGGCAAAGGGAA
CTCAAAGTTGGCATTCCCGTCACGGATGAGAATGGGAACCGCTTGGGGGAGTCGGCGAAC
GCTGCGAAACAAGCCATCACGCAAGTTGTCGTGTCCAGGATTCTCATGGCAGCCCCTGGC
ATGGCCATCCCTCCATTCATTATGAACACTTTGGAAAAGAAAGCCTTTTTGAAGAGGTTC
CCATGGATGAGTGCACCCATTCAAGTTGGGTTAGTTGGCTTCTGTTTGGTGTTTGCTACA
CCCCTGTGTTGTGCCCTGTTTCCTCAGAAAAGTTCCATGTCTGTGACAAGCTTGGAGGCC
GAGTTGCAAGCTAAGATCCAAGAGAGCCATCCTGAATTGCGACGCGTGTACTTCAATAAG
GGATTGTAA
Protein Properties
Number of Residues 322
Molecular Weight 35619.1
Theoretical pI 9.41
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 103-120
  • 147-167
  • 175-195
  • 229-249
  • 267-287
Protein Sequence
>Sideroflexin-1
MSGELPPNINIKEPRWDQSTFIGRANHFFTVTDPRNILLTNEQLESARKIVHDYRQGIVP
PGLTENELWRAKYIYDSAFHPDTGEKMILIGRMSAQVPMNMTITGCMMTFYRTTPAVLFW
QWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLNALTKHVSPLIGRFV
PFAAVAAANCINIPLMRQRELKVGIPVTDENGNRLGESANAAKQAITQVVVSRILMAAPG
MAIPPFIMNTLEKKAFLKRFPWMSAPIQVGLVGFCLVFATPLCCALFPQKSSMSVTSLEA
ELQAKIQESHPELRRVYFNKGL
GenBank ID Protein 23618867
UniProtKB/Swiss-Prot ID Q9H9B4
UniProtKB/Swiss-Prot Entry Name SFXN1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_022754.5
GeneCard ID SFXN1
GenAtlas ID SFXN1
HGNC ID HGNC:16085
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
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