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Identification
HMDB Protein ID HMDBP08695
Secondary Accession Numbers
  • 14416
Name Sideroflexin-5
Synonyms Not Available
Gene Name SFXN5
Protein Type Unknown
Biological Properties
General Function Involved in cation transmembrane transporter activity
Specific Function Transports citrate. Potential iron transporter
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
Function
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
cation transmembrane transporter activity
transporter activity
Process
establishment of localization
transport
transmembrane transport
ion transport
cation transport
Cellular Location
  1. Mitochondrion membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs SFXN5
Gene Sequence
>1023 bp
ATGGCGGATACAGCGACTACAGCATCGGCGGCGGCGGCTAGTGCCGCTAGCGCCTCGAGC
GATGCACCTCCTTTCCAACTGGGCAAACCCCGCTTCCAGCAGACGTCCTTCTATGGCCGC
TTCAGGCACTTCTTGGATATCATCGACCCTCGCACACTCTTTGTCACTGAGAGACGTCTC
AGAGAGGCTGTGCAGCTGCTGGAGGACTATAAGCATGGGACCCTGCGCCCGGGGGTCACC
AATGAACAGCTCTGGAGTGCACAGAAAATCAAGCAGGCTATTCTACATCCGGACACCAAT
GAGAAGATCTTCATGCCATTTAGAATGTCAGGTTATATTCCTTTTGGGACGCCAATTGTA
GTCGGTCTTCTCTTGCCCAACCAGACACTGGCATCCACTGTCTTCTGGCAGTGGCTGAAC
CAGAGCCACAATGCCTGTGTCAACTATGCAAACCGCAATGCGACCAAGCCTTCACCTGCA
TCCAAGTTCATCCAGGGATACCTGGGAGCTGTCATCAGCGCCGTCTCCATTGCTGTGGGC
CTTAATGTCCTGGTTCAGAAAGCCAACAAGTTCACCCCAGCCACCCGCCTTCTCATCCAG
AGGTTTGTGCCGTTCCCTGCTGTAGCCAGTGCCAATATCTGCAATGTGGTCCTGATGCGG
TACGGGGAGCTGGAGGAAGGGATTGATGTCCTGGACAGCGATGGCAACCTCGTGGGCTCC
TCCAAGATCGCAGCCCGACACGCCCTGCTGGAGACGGCGCTGACGCGAGTGGTCCTGCCC
ATGCCCATCCTGGTGCTACCCCCGATCGTCATGTCCATGCTGGAGAAGACGGCTCTCCTG
CAGGCACGCCCCCGGCTGCTCCTCCCTGTGCAAAGCCTCGTGTGCCTGGCAGCCTTCGGC
CTGGCCCTGCCGCTGGCCATCAGCCTCTTCCCGCAAATGTCAGAGATTGAAACATCCCAA
TTAGAGCCGGAGATAGCCCAGGCCACGAGCAGCCGGACAGTGGTGTACAACAAGGGGTTG
TGA
Protein Properties
Number of Residues 340
Molecular Weight 37123.8
Theoretical pI 9.76
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 103-123
  • 163-183
  • 254-274
  • 287-307
Protein Sequence
>Sideroflexin-5
MADTATTASAAAASAASASSDAPPFQLGKPRFQQTSFYGRFRHFLDIIDPRTLFVTERRL
REAVQLLEDYKHGTLRPGVTNEQLWSAQKIKQAILHPDTNEKIFMPFRMSGYIPFGTPIV
VGLLLPNQTLASTVFWQWLNQSHNACVNYANRNATKPSPASKFIQGYLGAVISAVSIAVG
LNVLVQKANKFTPATRLLIQRFVPFPAVASANICNVVLMRYGELEEGIDVLDSDGNLVGS
SKIAARHALLETALTRVVLPMPILVLPPIVMSMLEKTALLQARPRLLLPVQSLVCLAAFG
LALPLAISLFPQMSEIETSQLEPEIAQATSSRTVVYNKGL
GenBank ID Protein 62822196
UniProtKB/Swiss-Prot ID Q8TD22
UniProtKB/Swiss-Prot Entry Name SFXN5_HUMAN
PDB IDs Not Available
GenBank Gene ID AC012366
GeneCard ID SFXN5
GenAtlas ID SFXN5
HGNC ID HGNC:16073
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
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  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  4. Lockhart PJ, Holtom B, Lincoln S, Hussey J, Zimprich A, Gasser T, Wszolek ZK, Hardy J, Farrer MJ: The human sideroflexin 5 (SFXN5) gene: sequence, expression analysis and exclusion as a candidate for PARK3. Gene. 2002 Feb 20;285(1-2):229-37. [PubMed:12039050 ]